Attempted Suicide and Alcohol Dependence

自杀未遂和酒精依赖

基本信息

批准号：
7615110
负责人：
KENNETH R CONNER
金额：
$ 23.94万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-05-15 至 2011-01-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7615110
关键词：
Accounting Acute Address Affect Age Aggressive behavior Alcohol dependence Alcoholism Area Case-Control Studies Chronic Data Drug usage Economically Deprived Population Event Funding Gender Genetic Research Goals Guide prevention Heterogeneity Individual Inpatients Interview Lead Life Linear Regressions Logistic Regressions Loneliness Measures Modeling NIH Program Announcements National Institute on Alcohol Abuse and Alcoholism Neurobiology Outcome Partner in relationship Patients Pattern Phenotype Population Positioning Attribute Preparation Prevention Prevention program Race Recruitment Activity Regression Analysis Research Research Design Risk Risk Factors Role Screening procedure Series Severities Source Suicide Suicide attempt Suicide prevention Testing Woman Work accomplished suicide alcohol use disorder alcoholism therapy aloneness case control depression experience follow-up high risk instrument interest interpersonal conflict modifiable risk problem drinker response single episode major depressive disorder suicidal suicidal act suicidal behavior suicidal individual suicidal risk suicide model treatment duration

项目摘要

DESCRIPTION (provided by applicant): This application is in response to NIH Program Announcement 03 161 "Research on the reduction and prevention of suicidality" that was co-sponsored by NIAAA. Individuals with alcohol dependence are at high risk for both attempted and completed suicide. Patients in intensive treatment for alcoholism are at especially high risk. The purpose of this project is to enhance understanding of suicidal behavior among patients seeking treatment for alcohol dependence both by illuminating major differences between suicidal and non-suicidal individuals as well as by examining sources of heterogeneity within attempters. In Aim 1, the roles of reactive and proactive aggression in attempted suicide are examined, and in Aim 2, the focus is on the experience of aloneness, assessed objectively as living alone and subjectively as "loneliness." In Aim 3, a model of suicide planning that incorporates these variables is evaluated that posits reactive aggression and acute interpersonal difficulties (e.g., partner relationship break-ups) lead to low-planned (impulsive) suicide attempts in this population whereas depression and aloneness create the conditions for high-planned attempts. The aims are carried out using a retrospective case-control study design. Subjects in inpatient treatment for alcohol dependence who have made a suicide attempt within 90 days of treatment are identified using a uniform screen and followed up with a detailed research interview about the act of suicide, its circumstances, and hypothesized risk factors (e.g., reactive aggression). Non-attempter controls are recruited for comparison. Subjects include 40% women, 39% black individuals, and most are economically disadvantaged. Data on severity of alcohol dependence and other drug use are obtained, and accounted for in all analyses. Multivariate logistic regression analyses are used to compare cases and controls in Aims 1 and 2, and multivariate linear regression analyses of cases assessed on a continuum of level of planning of the attempt are used in Aim 3. Patterns related to age, gender, and race are also explored. Results may advance research on suicide and alcoholism focused on the reactive aggression phenotype, underscore the critical need to consider the interpersonal life of individuals seeking treatment for alcoholism who may be at risk for suicide, and inform treatments that seek to identify and affect the course of low-planned and high-planned suicidal behavior in this population.

描述（由申请人提供）：本申请是对 NIH 计划公告 03 161“减少和预防自杀行为的研究”的回应，该计划由 NIAAA 共同赞助。酒精依赖者自杀未遂和自杀的风险都很高。接受酒精中毒强化治疗的患者风险尤其高。该项目的目的是通过阐明自杀者和非自杀者之间的主要差异以及检查尝试者的异质性来源，增强对寻求酒精依赖治疗的患者自杀行为的理解。在目标 1 中，研究了反应性和主动攻击性在自杀未遂中的作用，在目标 2 中，重点是孤独的体验，客观评估为独居，主观评估为“孤独”。在目标 3 中，评估了包含这些变量的自杀计划模型，该模型假设反应性攻击和严重的人际困难（例如，伴侣关系破裂）会导致该人群计划性低（冲动）的自杀企图，而抑郁和孤独则会导致高计划尝试的条件。这些目标是通过回顾性病例对照研究设计来实现的。使用统一的筛查来识别因酒精依赖住院治疗的受试者，如果他们在治疗后 90 天内尝试过自杀，并对其进行详细的研究访谈，了解自杀行为、其情况和假设的风险因素（例如，反应性攻击））。招募非尝试者对照进行比较。受试者包括 40% 的女性、39% 的黑人，并且大多数处于经济弱势地位。获得有关酒精依赖和其他药物使用严重程度的数据，并在所有分析中进行说明。多元逻辑回归分析用于比较目标 1 和 2 中的病例和对照，目标 3 中使用对在尝试计划的连续水平上评估的病例进行多元线性回归分析。与年龄、性别和种族相关的模式也被探索。结果可能会推进针对反应性攻击表型的自杀和酗酒研究，强调迫切需要考虑可能有自杀风险的酗酒者寻求治疗的个人的人际生活，并为寻求识别和影响过程的治疗提供信息。该人群中的低计划和高计划自杀行为。