Regenerative Engineering Training Program (RE-Training)

再生工程培训计划（RE-Training）

• 批准号: 10424463
• 负责人: Guillermo Antonio Ameer
• 金额: $ 21.28万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10424463
• 关键词: Regenerative engineering; Training; Training Programs

Summary for the Regenerative Engineering Training Program A major health challenge that our society faces is premature death and morbidity associated with the shortage of healthy donor tissues or organs for transplantation and the limited regenerative capacity of our body due to serious injury or disease. Research that entails the convergence of disparate disciplines to create new frameworks, tools, and a new common language is positioned to better enable solutions to complex problems such as the aforementioned one. Regenerative engineering is the convergence of advanced materials science, stem cell and developmental biology, physical sciences, and translational medicine to reconstruct or regenerate complex tissues and organs. The objective of this training program is to offer the curriculum and environment needed to train the next generation of convergence researchers that are versed in the development and use of regenerative engineering solutions. Specifically, program graduates will have the capacity to develop scientific, technical, and clinical knowledge and skills that will enable them to recognize and solve challenges associated with the restoration of tissue and organ function. Core innovative elements of the program include: 1) clinical immersion rotations to gain direct insight into organ failure and tissue reconstruction challenges that afflict patients and physicians; 2) a 3-member mentorship team that includes 1 clinical, 1 life/physical sciences, and 1 engineering faculty member; 3) internships at companies with product development expertise involving regenerative engineering; and 4) experiential courses to learn essential experimental techniques. The program, housed in the Center for Advanced Regenerative Engineering at Northwestern University, will be a joint effort involving diverse faculty from the schools of engineering, arts and sciences, and medicine. Northwestern University has a long history of transdisciplinary collaborations and has the resources and pedagogical tools to establish a unique national program to train new leaders. Trainees will be mentored by preceptors working in molecular and stem cell biology, nanotechnology, additive manufacturing, regenerative engineering, molecular biophysics, biomaterials, bioelectronics, surgery, and translational medicine. Examples of ongoing collaborations include programs for the regeneration of bladder, bone, blood vessels, pancreas, liver, kidney, skin, muscle, the immune system, and nerves. We propose to train 3 pre-doctoral trainees in year 1 and 6 trainees for each of years 2-5. Trainees will be selected from applicants in the department of Biomedical Engineering, including those from the medical scientist training program. We expect to produce the next generation of regenerative engineering thought leaders that are competent in convergence research aimed at tackling the aforementioned societal health challenges and improving patient outcomes.

再生工程培训计划摘要 我们社会面临的一个主要健康挑战是过早死亡和与疾病相关的发病率 用于移植的健康供体组织或器官短缺，再生能力有限 我们的身体由于严重受伤或疾病。需要不同学科融合的研究 创建新的框架、工具和新的通用语言，以更好地实现解决方案 解决诸如上述问题之类的复杂问题。再生工程是融合 先进材料科学、干细胞和发育生物学、物理科学和 重建或再生复杂组织和器官的转化医学。此举的目的 培训计划的目的是提供培训下一代所需的课程和环境 精通再生工程开发和使用的融合研究人员 解决方案。具体来说，该项目的毕业生将有能力发展科学、技术和 临床知识和技能将使他们能够认识和解决与以下相关的挑战 组织和器官功能的恢复。该计划的核心创新要素包括：1）临床 浸入式旋转，以直接了解器官衰竭和组织重建的挑战 困扰患者和医生； 2) 3 人指导团队，其中包括 1 名临床人员、1 名生命/身体人员 科学和 1 名工程教员； 3）产品开发公司实习 涉及再生工程的专业知识； 4）学习必备的体验式课程 实验技术。该项目位于高级再生工程中心 在西北大学，将是来自工程学院的不同教师的共同努力， 艺术和科学以及医学。西北大学具有悠久的跨学科历史 合作并拥有资源和教学工具来建立独特的国家计划 培养新的领导者。学员将接受从事分子和干细胞生物学工作的导师的指导， 纳米技术、增材制造、再生工程、分子生物物理学、生物材料、 生物电子学、外科和转化医学。持续合作的例子包括 膀胱、骨骼、血管、胰腺、肝脏、肾脏、皮肤、肌肉、 免疫系统和神经。我们建议第一年培养 3 名博士生，6 名博士生 每年 2-5 年。实习生将从生物医学系的申请者中选拔 工程，包括来自医学科学家培训计划的工程。我们期望生产出 具有融合能力的下一代再生工程思想领袖 旨在解决上述社会健康挑战并改善患者状况的研究 结果。