IMAGING/ENGINEERING

成像/工程

• 批准号: 7719694
• 负责人: TERENCE H WONG
• 金额: $ 35.07万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7719694
• 关键词: Area; Canis familiaris; Cervix Uteri; Clinical; Complex; Data; Development; Doctor of Philosophy; Documentation; Engineering; Equipment; Fever; Heating; Human Resources; Image; Image Analysis; Imaging Techniques; Invasive; Liposomes; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Maintenance; Microscopy; PET/CT scan; Patients; Physiologic pulse; Physiology; Positron-Emission Tomography; Pulse taking; Range; Resources; Rodent; Services; System; Technology; Testing; Thermometry; Update; base; design; hyperthermia treatment; image processing; in vivo; programs; quality assurance; repaired; research study; treatment planning; tumor

The previous Imaging and Engineering Cores have been combined into a new Core. Although larger and more complex than separate Cores, the new combined core design will better serve the needs of the Program by integrating imaging and engineering resources. This integration has become even more important since the development of the combined MRI / regional hyperthermia system. The Core will provide a broad range of services to the Program. The Core will provide routine technical support, quality assurance, and Radiological expertise for the imaging studies of the Program, including the dynamic MRI studies, MRS, and PET/CT studies (Project 5), the in-vivo rodent MRI liposome studies (Project 3), and dynamic CT studies in canine patients (Project 4). In addition, the Core will provide engineering support and expertise for the hyperthermia treatments (Project 5) and phantom experiments (Projects 1 and 2) of the Program, including quality assurance of invasive and non-invasive MR-based thermometry. Finally, the Core will provide ongoing development and improvement in imaging techniques and hyperthermia equipment over the course of the Program. The overall objective of the Core is to provide imaging and engineering support for non-invasive assessment of heat-induced changes in tumor physiology, and to provide the combined imaging and engineering expertise required for image-based hyperthermia treatment planning and MR-based feedbackcontrolled hyperthermia delivery. Specific Aim 1 - The Core will provide technical support, quality assurance, and Radiological expertise for the clinical and experimental imaging studies of the Program Specific Aim 2 - The Core will provide technical and engineering support during the hyperthermia treatments and phantoexperiments in the Program Specific Aim 3 - The Core will develop improvements in imaging techniques, provide technical advances in the hyperthermia equipment, and updates in technology as they evolve throughout the course of the Program.

以前的成像和工程核心已合并为新的核心。虽然更大和 比单独的核心更复杂，新的组合核心设计将更好地满足 通过集成成像和工程资源来计划。这种整合变得更加 重要的是，自组合MRI /区域高温系统的发展。核心将提供 该计划的各种服务。核心将提供常规的技术支持，质量保证， 以及该程序成像研究的放射学专业知识，包括动态MRI研究，MRS， 和PET/CT研究（项目5），体内啮齿动物MRI脂质体研究（项目3）和动态CT 犬类患者的研究（项目4）。此外，核心将为工程支持和专业知识提供 该计划的高温治疗（项目5）和幻影实验（项目1和2）， 包括侵入性和非侵入性MR基温度法的质量保证。最后，核心将 提供持续的开发以及成像技术和高温设备的改进 程序课程。 核心的总体目标是为非侵入性提供成像和工程支持 评估热诱导的肿瘤生理变化，并提供联合成像和 基于图像的高温治疗计划所需的工程专业知识和基于MR的反馈控制 热疗输送。 具体目标1-核心将为技术支持，质量保证和放射学专业知识提供 该程序的临床和实验成像研究 特定目标2-核心将在高温期间提供技术和工程支持 该计划中的治疗和幻象表明 特定目标3-核心将在成像技术方面发展进步，提供技术进步 热疗设备以及技术的更新在整个过程中的发展 程序。