Integrated Multifunctional Imaging of Deep Vein Thrombosis

深静脉血栓形成的综合多功能成像

• 批准号: 7662486
• 负责人: WALTER G SCOTT
• 金额: $ 55.07万
• 依托单位: WINPROBE CORPORATION
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-17 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7662486
• 关键词: Acoustics; Acute; Address; Advanced Development; Age; Aging; Algorithms; Anatomy; Animals; Anticoagulation; Arts; Biomechanics; Blood Clot; Blood Platelets; Blood coagulation; Businesses; Cessation of life; Chronic; Classification; Clinical; Clinical Engineering; Clinical Management; Clinical Protocols; Clinical Research; Coagulation Process; Color; Commit; Complication; Computer Systems Development; Computer software; Custom; Data; Deep Vein Thrombosis; Detection; Developed Countries; Developing Countries; Development; Diagnosis; Diagnostic Imaging; Diagnostic Procedure; Elasticity; Elements; Engineering; Erythrocytes; Fibrin; Goals; Gold; Hospital Mortality; Image; Imagery; Imaging Device; Imaging Techniques; Investigation; Laboratories; Lasers; Leukocytes; Low-Molecular-Weight Heparin; Maps; Marketing; Measures; Mechanics; Medical center; Methods; Michigan; Microsurgery; Modeling; Modification; Monitor; Morbidity - disease rate; Multimodal Imaging; Names; Neurofibrillary Tangles; Optics; Patients; Performance; Phase; Phase I Clinical Trials; Physiologic pulse; Postdoctoral Fellow; Principal Investigator; Procedures; Property; Pulmonary Embolism; Radiology Specialty; Research; Research Design; Research Personnel; Resolution; Risk; Signal Transduction; Small Business Innovation Research Grant; Source; Staging; Structure; System; Systems Integration; Techniques; Technology; Testing; Texas; Thrombus; Time; Tissues; Ultrasonic Transducer; Ultrasonics; Ultrasonography; United States; Universities; Venous; Work; absorption; anticancer research; austin; base; cellular imaging; commercialization; deep vein; design; experience; image processing; imaging modality; member; mortality; new technology; optical fiber; optical imaging; pre-clinical; professor; programs; prototype; radiologist; reconstruction; research clinical testing; skills; tool; treatment planning

DESCRIPTION (provided by applicant): Deep venous thrombosis (DVT), and its sequelae, pulmonary embolism (PE), is a significant clinical problem, representing the leading cause of preventable in-hospital mortality in the USA and other developed countries. Indeed, anywhere from 60,000 to 200,000 people are dying each year in the United States because of DVT related pulmonary embolism. Therefore, reliable detection and diagnosis of DVT is of paramount importance. Once detected, acute clots must be differentiated from chronic DVT for appropriate treatment. However, there are no reliable, clinically available methods to stage DVT. Even the gold standard diagnostic technique, duplex venous ultrasound, can only detect but not age these clots. Therefore once a DVT is detected, highly potent, low-molecular weight heparin anticoagulation therapy, with its associated morbidity and mortality, is often given to over compensate for a PE risk from what might only be a chronic thrombus. Over time, as a clot ages and matures, DVT consistently hardens. Previous studies demonstrated that elastography a technique to image elastic properties of tissue can be used to reliably differentiate the chronic and acute DVT. In addition to elasticity contrast, optical absorption of DVT changes with blood clot maturation the acute clots are associated with high concentration of red blood cells, and chronic composed of tangled mesh of platelets, fibrin, and degenerating leukocytes. Consequently, the photoacoustic imaging an ultrasound-based imaging of optical absorption can be used to further characterize blood clots thus assisting the classification of detected DVT. Therefore, we propose to develop an integrated multifunctional imaging system to simultaneously detect and differentiate DVT based on grayscale and Doppler/color flow ultrasound imaging, photoacoustic imaging and elastography. The combined imaging will enhance DVT detection, diagnosis and staging without significant modification in current clinical protocol of ultrasound examination of DVT. The main objective of this fast-track SBIR program is to develop and test the integrated ultrasound, photoacoustic and elasticity imaging system to detect and age DVT. To achieve our objective, we will design and build an ultrasound imaging system capable of simultaneous, real-time ultrasound, photoacoustic and strain imaging of blood clots in deep vein, and subsequent visualization of DVT elasticity. We will then test the developed system using tissue-mimicking models of DVT followed by clinical studies of patients with known acute and chronic blood clots. Based on the results of these studies, it is the long-range goal of the overall program to develop, thoroughly test and commercialize a real-time ultrasound-based imaging system for DVT detection, diagnosis and aging. The central theme of this project is to design, develop and commercialize a real-time integrated multimodal ultrasound-based imaging system to detect and age deep vein thrombosis. Our research program is focused on development of an advanced imaging tool that takes full advantage of the many synergistic features of three complementary imaging modalities ultrasound, photoacoustics, and elastography. Integrated ultrasound, photoacoustic and elasticity imaging is a novel technology capable of accurate visualization of both structural and functional properties of tissue and it may be useful far beyond DVT detection and diagnosis. The applications of multimodal imaging may be extended into cancer research, diagnostic imaging and therapy monitoring, cellular imaging, small animal imaging, microsurgery, etc. The current study, however, is a part of a focused program to develop and commercialize much needed yet unavailable clinical tool for DVT detection, diagnosis and characterization.

描述（由申请人提供）： 深静脉血栓形成（DVT）及其后遗症肺栓塞（PE）是一个重大的临床问题，代表了美国和其他发达国家可预防院内死亡率的主要原因。实际上，由于与DVT相关的肺栓塞，在美国，每年有60,000至200,000人死亡。因此，DVT的可靠检测和诊断至关重要。一旦检测到，必须将急性血块与慢性DVT区分开以进行适当的治疗。但是，尚无可靠的临床可用方法来进行DVT。即使是黄金标准诊断技术，双链静脉超声，也只能检测到这些凝块的年龄。因此，一旦检测到DVT，高度有效的低分子量肝素抗凝治疗（具有相关的发病率和死亡率）通常会因仅是慢性血栓而过度补偿PE风险。随着时间的流逝，随着凝块的年龄和成熟，DVT始终变硬。先前的研究表明，弹性学是一种图像组织的弹性特性的技术，可用于可靠地区分慢性和急性DVT。除弹性对比度外，DVT随着血凝块成熟而变化的光学吸收急性血块与高浓度的红细胞相关，以及由血小板，纤维蛋白和退化白细胞纠结的网状组成的慢性凝块。因此，光声成像基于超声的光吸收成像可用于进一步表征血凝块，从而有助于对检测到的DVT的分类。因此，我们建议开发一个集成的多功能成像系统，以同时检测和分化基于灰度和多普勒/颜色流量超声成像，光声成像和弹性图的DVT。组合成像将增强DVT检测，诊断和分期，而无需在当前的DVT超声检查临床方案中进行重大修改。这个快速轨道SBIR计划的主要目的是开发和测试集成的超声，光声和弹性成像系统以检测和年龄DVT。为了实现我们的目标，我们将设计和构建一个超声成像系统，可同时实时超声，光声和菌株成像深静脉中的血液凝块以及随后的DVT弹性可视化。然后，我们将使用DVT的组织模型模型测试开发的系统，然后对已知急性和慢性血液凝块患者的临床研究进行临床研究。根据这些研究的结果，这是整个计划的远程目标，旨在开发，对基于实时超声的成像系统进行彻底测试和商业化以进行DVT检测，诊断和衰老。该项目的中心主题是设计，开发和商业化实时集成的多模式超声成像系统，以检测和年龄深静脉血栓形成。我们的研究计划的重点是开发高级成像工具，该工具充分利用了三种互补成像模式超声，光声和弹性的许多协同特征。集成的超声，光声和弹性成像是一种能够准确可视化组织结构和功能特性的新技术，它可能远远超出DVT检测和诊断。多模式成像的应用可以扩展到癌症研究，诊断成像和治疗监测，细胞成像，小动物成像，微外观手术等。但是，当前的研究是针对性计划的一部分，旨在开发和商业化很多临床工具，以实现DVT检测，诊断和表征。