Epidemiology of Malaria Invasion in Mutare City and Targets for Elimination, Zimbabwe

津巴布韦穆塔雷市疟疾侵袭的流行病学和消除目标

基本信息

批准号：
10297612
负责人：
Sungano Mharakurwa
金额：
$ 10.21万
依托单位：
AFRICA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-17 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10297612
关键词：
Affect Africa African Altitude Area Award Awareness Back Behavior Biological Assay Biology Blood Breeding Characteristics Chemoprophylaxis Child Care Cities Collaborations Collection Communication Communities Conduct Clinical Trials Country Culicidae Data Data Analyses Detection Development Diagnosis Disease Drug resistance Ensure Epidemiologic Factors Epidemiology Evaluation Feeding behaviors Genetic Genomics Goals Grant Habitats Health Health care facility Healthcare Human Infection Insecticides International Intervention Laboratories Lead Malaria Measures Mentors Molecular Molecular Analysis Molecular Epidemiology Monitor Morphology Parasites Pattern Plasmodium falciparum Predisposition Prevalence Preventive measure Preventive treatment Privatization Prophylactic treatment Public Health Publications Recommendation Research Research Personnel Research Project Grants Residual state Risk Risk Factors Sampling Sanitation Sentinel Site Southern Africa Specimen Spottings Surveillance Program Surveys Temperature Testing Time Translational Research Travel Universities Work Writing Zimbabwe burden of illness career career development case control design diagnostic accuracy experience follow-up histidine-rich proteins indexing intervention program malaria transmission member molecular marker multidisciplinary operation programs restoration scale up suburb symposium transmission process uptake vector vector control vector mosquito

项目摘要

Epidemiology of Malaria Invasion in Mutare City and Targets for Elimination, Zimbabwe PROJECT SUMMARY/ABSTRACT This award will enable Dr. Sungano Mharakurwa to ascertain the epidemiological determinants of urban malaria invasion in Zimbabwe in order to identify intervention targets for restoring malaria-free status. The study will leverage on an existing national malaria vector surveillance programme established at Africa University in conjunction with the Ministry of Health and Child Care’s National Malaria Control Programme and its partners. This work will be undertaken with guidance from an experienced team of mentors with strong complementary expertise in public health, epidemiology, transmission biology, parasite genetics, genomics and human studies. Dr. Mharakurwa will further his career development by; 1) conducting and directing the laboratory assays, 2) undertaking short courses in molecular epidemiology, quantitative and sequence data analysis, translation research, conduct of clinical trials and grant-writing; and 3) presenting at international research conferences and writing publications. The program will be pivotal in enabling Dr. Mharakurwa to establish a career and strong collaboration as an independent malaria researcher in Zimbabwe. While Zimbabwe has made significant progress rolling back malaria, a serious setback of reinvasion from endemic to erstwhile malaria-free areas of the country, including highly populated cities, is emerging. The proposed research project will employ molecular and field approaches to understand the seasonal distribution, determinants and characteristics of parasites, vectors and humans associated with urban malaria invasion into Mutare City of Zimbabwe in order to identify strategies for reclaiming zero transmission.

穆塔雷市疟疾侵袭的流行病学和消除目标，津巴布韦项目概要/摘要该奖项将使 Sungano Mharakurwa 博士能够确定流行病学决定因素津巴布韦城市疟疾入侵的情况，以确定恢复的干预目标该研究将利用现有的国家疟疾媒介监测。非洲大学与卫生和儿童部联合设立的项目这项工作将与 Care 的国家疟疾控制计划及其合作伙伴共同开展。来自经验丰富的导师团队的指导，他们在公共领域具有强大的互补专业知识健康、流行病学、传播生物学、寄生虫遗传学、基因组学和人类研究。 Mharakurwa 将通过以下方式进一步发展他的职业发展： 1) 管理和指导实验室分析，2) 参加分子流行病学、定量和序列方面的短期课程数据分析、翻译研究、临床试验的实施和资助撰写；以及 3) 演示；该计划将在国际研究会议和写作出版物中发挥关键作用。使 Mharakurwa 博士能够作为独立人士建立自己的职业生涯和强有力的合作津巴布韦的疟疾研究人员表示，津巴布韦在遏制疟疾方面取得了重大进展。疟疾从流行地区重新入侵到以前无疟疾地区的严重挫折国家，包括人口稠密的城市，正在兴起。采用分子和现场方法来了解季节分布、决定因素与城市疟疾入侵相关的寄生虫、媒介和人类的特征深入津巴布韦穆塔雷市，以确定恢复零传播的策略。