Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at Vanderbilt

总体而言：范德堡大学尤尼斯·肯尼迪·施赖弗智力与发育障碍研究中心

• 批准号: 10229591
• 负责人: Jeffrey L Neul
• 金额: $ 136.41万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-06 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10229591
• 关键词: Academic Medical Centers; Affect; Antipsychotic Agents; Basic Science; Behavioral; Biomedical Research; Caregivers; Caring; Clinical; Clinical Research; Clinical Trials; Communication; Communities; Computerized Medical Record; Data; Data Science; Development; Developmental Disabilities; Diagnosis; Disease; Disease model; Down Syndrome; Education; Evaluation; Faculty; Family; Foundations; Funding; Future; Gap Junctions; Genotype; Goals; Image; Individual; Infrastructure; Institutes; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Interdisciplinary Study; Intervention; Leadership; Longevity; Machine Learning; Medical Records; Methods; Mission; Modeling; National Institute of Child Health and Human Development; Neurodevelopmental Disability; Obesity; Outcome; Participant; Pharmaceutical Preparations; Pharmacogenetics; Phase; Pilot Projects; Policy Research; Prevention; Problem behavior; Publications; Research; Research Personnel; Research Project Grants; Resources; Risk; Sampling; Schools; Series; Services; Structure; Techniques; Technology; Testing; Training; Translational Research; Translations; United States National Institutes of Health; Universities; Vision; Weight Gain; Work; autism spectrum disorder; base; behavioral phenotyping; clinical translation; comorbidity; cost effective; developmental disease; disability; drug-induced weight gain; experience; image processing; implementation science; improved; individualized medicine; individuals with autism spectrum disorder; innovation; large datasets; lectures; meetings; multidisciplinary; novel; personalized approach; personalized care; personalized medicine; population based; pragmatic trial; predictive modeling; programs; public health relevance; recruit; research study; success; targeted treatment; translational neuroscience; trial comparing

Founded in 1965 as one of the original Intellectual and Developmental Disorders Research Centers (IDDRC), the Vanderbilt Kennedy Center (VKC) IDDRC serves as the central nexus across Vanderbilt for interdisciplinary research, communication, and training in intellectual and developmental disabilities (IDD). The VKC IDDRC serves as a trans-institutional institute that brings together over 200 faculty from 38 departments in 10 schools at Vanderbilt. The VKC’s mission to facilitate discoveries that inform best practices to improve the lives of people with IDD and their families. This mission is met by leveraging our outstanding institutional resources and support, partnering with disability communities, and capitalizing on synergistic interactions across the VKC’s federally-designated centers: the VKC IDDRC, a University Center of Excellence in Developmental Disabilities and a Leadership Education in Neurodevelopmental Disabilities program. The IDDRC as the centerpiece of the VKC is the foundational organizing structure that creates a “Center culture” wherein research and discovery permeates the VKC’s broader training and service activities, thus enhancing the translational research goals of the IDDRC. Demonstrable IDDRC success includes 976 investigator- authored publications and robust NIH funding to Vanderbilt to support IDD-related research ($52.6M in FY20). Harnessing and leveraging this trans-institutional strength to focus on unique challenges in IDD, the overarching goal of the next phase of the IDDRC is to develop precision care for IDD by providing infrastructure and scientific leadership to enable rapid translation of basic discoveries into high- impact IDD interventions and treatments. Three global Aims guide the IDDRC’s work. Aim 1 provides core services to enable and disseminate impactful research on individualizing treatments based upon the causes, mechanisms, and contributing co-morbid sequelae of IDD; Aim 2 focuses on incorporating innovative methods and approaches to enhance multidisciplinary IDD research; and Aim 3 proposes to conduct a signature research project to improve the precision use of antipsychotic medication in people with autism. Across these Aims and five Cores supported by the IDDRC (Administrative, Clinical Translational, Translational Neuroscience, Behavioral Phenotyping, and Data Sciences), three themes permeate our work: (1) recruitment of highly-skilled researchers not currently conducting IDD research (non-traditional researchers); (2) inclusion of IDD participants into research studies that currently do not include IDD (non-traditional subjects); and (3) incorporation of novel scientific approaches and methods (non-traditional approaches). Our IDDRC is ideally posed to enable rapid discovery of precision care approaches by supporting 50 investigators leading 70 research projects (15 from NICHD) and, as highlighted by the Signature Research Project, to promote and implement generative, novel, and impactful research directions, thus meeting the NICHD’s vision of applying newly evolved technologies and approaches to rapidly accelerate the prevention and/or amelioration of IDDs.

成立于 1965 年，是最初的智力和发育障碍研究中心之一 (IDDRC)、范德比尔特肯尼迪中心 (VKC) IDDRC 是整个范德比尔特大学的中心枢纽 智力和发育障碍 (IDD) 的跨学科研究、交流和培训。 VKC IDDRC 是一个跨机构机构，汇集了来自 38 个系的 200 多名教职员工 VKC 的使命是促进发现，为改进提供最佳实践。 通过利用我们杰出的机构来实现 IDD 患者及其家人的生活。 资源和支持，与残疾人社区合作，并利用协同互动 VKC 联邦指定中心：VKC IDDRC，一所大学卓越中心 发育障碍和神经发育障碍领导力教育计划。 IDDRC 作为 VKC 的核心，是创建“中心文化”的基础组织结构 然而，研究和发现渗透到 VKC 更广泛的培训和服务活动中，从而增强了 第 976 章 授权出版物和 NIH 向范德比尔特提供的大量资金来支持 IDD 相关研究（20 财年为 5260 万美元）。 利用和利用这种跨机构优势，专注于 IDD 的独特挑战， IDDRC 下一阶段的总体目标是通过提供 基础设施和科学领导力，使基本发现能够快速转化为高科技 影响 IDD 干预和治疗的三个全球目标指导着 IDDRC 的工作，目标 1 提供了核心。 提供服务，以实现和传播基于病因的个体化治疗的有影响力的研究， 目标 2 侧重于整合创新方法； 以及加强多学科IDD研究的方法；目标3建议进行签名 研究项目旨在提高自闭症患者抗精神病药物的精确使用。 IDDRC 支持的目标和五个核心（管理、临床转化、转化 神经科学、行为表型和数据科学），三个主题贯穿我们的工作：（1）招聘 目前未进行 IDD 研究的高技能研究人员（非传统研究人员）；(2) 包容性； IDD 参与者参与目前不包括 IDD 的研究（非传统受试者）；以及 (3) 我们的 IDDRC 非常适合结合新颖的科学方法和方法（非传统方法）。 通过支持 50 名研究人员领导 70 名研究人员，能够快速发现精准护理方法 研究项目（NICHD 的 15 个），并且如标志性研究项目所强调的那样，旨在促进和 实施生成性、新颖性和有影响力的研究方向，从而满足 NICHD 的应用愿景 新发展的技术和方法可快速加速预防和/或改善 IDD。