Cancer Center Support Grant

癌症中心支持补助金

• 批准号: 7345543
• 负责人: ROBERT Alan FIGLIN
• 金额: $ 234.25万
• 依托单位: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2012-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7345543
• 关键词: Cancer; Center; Support; Grant

DESCRIPTION (provided by applicant): This renewal application requests funding for the 25th through 29th years of the NCI Cancer Center Support Grant of the City of Hope Comprehensive Cancer Center. The Center now has five research programs: one basic research Program (Cancer Biology, CB); three clinical/translational research Programs (Developmental Cancer Therapeutics, DCT; Cancer Immunotherapeutics, Cl; Hematologic Malignancies, HM); and one population research program (Cancer Control and Population Sciences, CCPS). Twelve shared resources support the scientific activities of the members, including two new cores (Small Animal Imaging; Clinical Immunobiology Correlative Studies Laboratory). Three developing cores are proposed (High Throughput Screening; Synthetic & Biopolymer Chemistry; Survey Research). Membership has grown by 45% in the preceding program period with the recruitment of 37 new Full Members, including several key senior leaders (Richard Jove, PhD, Deputy Director; R. Figlin, MD, Associate Director [AD] for Clinical Research). Other key leadership positions have also been filled through internal appointments (Smita Bhatia, MD, MPH, AD for Population Research; Joyce Niland, PhD, AD for Information Sciences; and Yun Yen, MD, PhD, AD for Translational Research). As a result of our program restructuring, recruitment and infrastructure development, we now believe we have a Center where our five Programs represent a continuum in which basic and translational studies in the basic science Program, CB, and one clinical Program, DCT, can be linked to Phase I and II clinical protocols in all three clinical programs (DCT, Cl, HM) and follow-up studies in survivorship and symptom management in the population sciences program (CCPS). All these activities are made possible by a Center and Institutional infrastructure that supports basic and translational research in biological and, now, small molecule approaches to cancer in an extraordinarily collaborative fashion. Such interaction has resulted in the Center's first SPORE, in lymphoma; a recent W.M. Keck Foundation award; and the renewal of eight large, multi-investigator awards. During the next funding period, we will build on these achievements so that the City of Hope Comprehensive Cancer Center takes the next step in its evolution: translating more laboratory discoveries into innovative clinical trials and developing disease-based research programs. The 82 Full Members and 90 Associate Members of the Center Programs have published 1001 articles, book chapters, etc., since the last competitive grant review. Of these, 28% are intraprogrammatic and 22% are interprogrammatic publications.

描述（由申请人提供）：此续签申请要求为NCI癌症中心支持综合癌症中心的NCI癌症中心支持授予25年至29年的资金。该中心现在有五个研究计划：一项基础研究计划（Cancer Biology，CB）；三个临床/转化研究计划（发育癌症治疗，DCT；癌症免疫治疗剂，CL；血液系统恶性肿瘤，HM）；以及一项人口研究计划（癌症控制和人口科学，CCPS）。十二个共享资源支持成员的科学活动，包括两个新的核心（小动物成像；临床免疫生物学相关研究实验室）。提出了三个发育中的核心（高吞吐量筛选；合成和生物聚合物化学；调查研究）。在上一个计划期间，成员资格增长了45％，招募了37名新的正式成员，其中包括几位主要高级领导者（Richard Jove，PhD，副主任； R. R. Figlin，MD，医学博士，临床研究副总监[AD]）。其他关键领导职务也通过内部任命（医学博士Smita Bhatia，MPH，人口研究广告；乔伊斯·尼兰德（Joyce Niland），博士学位，广告信息科学；以及Yun Yen Yen Yen，MD，PhD，AD，用于转化研究）。由于我们的计划进行了重组，招聘和基础设施的发展，我们现在相信我们有一个中心，我们的五个计划代表了一个连续性，其中基础科学计划，CB和一个临床计划（DCT）可以与I阶段和II期临床计划（DCT，CL，CL，CL，HM）和后续研究中的I型和II期临床协议有关，并在SCI中进行了症状（SCI）conscom cons com sak和SCIS症状。所有这些活动都是由中心和机构基础设施提供的，该基础设施支持生物学的基本和转化研究，现在，以非常合作的方式解决了癌症的小分子方法。这种相互作用导致该中心在淋巴瘤中的第一个孢子。最近的W.M.凯克基金会奖；以及八个大型多功能人奖项的续签。 在下一个资金期间，我们将基于这些成就，以便希望综合癌症中心迈出了其进化的下一步：将更多的实验室发现转化为创新的临床试验并制定基于疾病的研究计划。自上次竞争性赠款评论以来，该中心计划的82名成员和90名员工已发表了1001篇文章，书籍章节等。其中，有28％是术中，22％是解释性媒介出版物。