MASALA-2G: Multi-level Assessment of the South Asian Life-course of Atherosclerosis (2nd Generation Offspring Study)

MASALA-2G：南亚动脉粥样硬化生命历程的多层次评估（第二代后代研究）

• 批准号: 10407490
• 负责人: Nilay S. Shah
• 金额: $ 16.28万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10407490
• 关键词: 21 year old; Acculturation; Address; Adult; Adult Children; Age; American Heart Association; Americas; Ancillary Study; Asian Americans; Asian population; Atherosclerosis; Bangladesh; Behavior Therapy; Bhutan; Body Composition; Body mass index; Cardiology; Cardiovascular Models; Cardiovascular system; Child; Clinical; Clinical Sciences; Collaborations; Communities; Development; Development Plans; Diabetes Mellitus; Epidemiology; Ethnic Origin; Ethnic group; Event; Foundations; Funding; Future; Generations; Genomic approach; Genomics; Guidelines; Health; Health Promotion; Health Sciences; Health behavior; High Prevalence; Hypertension; Immigrant; India; Individual; Infrastructure; Institutes; Intervention; Intervention Trial; Interview; Investigation; K-Series Research Career Programs; Knowledge; Life; Life Cycle Stages; Life course epidemiology; Logic; Maldives; Measures; Mediator of activation protein; Medicine; Mentors; Mentorship; Minority Groups; Mission; Myocardial Infarction; National Heart, Lung, and Blood Institute; Neighborhood Health Center; Neighborhoods; Nepal; Obesity; Pakistan; Parents; Participant; Patient Recruitments; Persons; Pilot Projects; Population; Population Heterogeneity; Positioning Attribute; Prevalence; Prevention; Prevention strategy; Preventive Medicine; Primary Prevention; Protocols documentation; Race; Research; Research Infrastructure; Research Personnel; Research Training; Risk; Risk Assessment; Risk Factors; Social Network; South Asian; Sri Lanka; Statistical Methods; Statistical Models; Structure; Testing; Time; Training; Translational Research; Universities; behavioral health intervention; cardiometabolic risk; cardiovascular disorder prevention; cardiovascular disorder risk; cardiovascular health; career development; cohort; community engaged research; community engagement; coronary artery calcium; disease disparity; enhancing factor; ethnic diversity; evidence base; experience; feasibility trial; genome sciences; genome wide association study; health difference; health disparity populations; heart disease prevention; high risk population; implementation science; improved; intervention mapping; mortality; multidisciplinary; novel; offspring; polygenic risk score; population based; premature; prevent; preventive intervention; protective factors; racial and ethnic; recruit; research and development; skills; social culture; socioeconomics; tool; training opportunity; young adult

PROJECT SUMMARY/ABSTRACT This career development award will provide Dr. Nilay Shah the opportunity to develop as an independent investigator of community and clinical cardiovascular disease prevention in the South Asian American population, and build on his experience in population epidemiology and clinical cardiovascular medicine. South Asians experience a disproportionately higher burden of atherosclerotic cardiovascular disease (ASCVD) at younger ages compared to other race/ethnic groups, but little is known about antecedent cardiovascular health in 2nd generation young adult South Asian Americans to inform early life prevention strategies in this risk- enhanced group. The proposed application aims to pilot MASALA-2G, the Multi-level Assessment of the South Asian Life-course of Atherosclerosis (2nd Generation Offspring Study), an offspring study to the Mediators of Atherosclerosis in South Asians Living in America (MASALA) cohort who are predominantly 1st generation immigrant South Asians. MASALA-2G represents a foundational investigation in the cardiovascular health of the South Asian American population and aligns directly with the National Heart, Lung, and Blood Institute mission and objective to promote the prevention of heart diseases in diverse populations. Under the mentorship of Drs. Namratha Kandula and Mark Huffman, who are leading researchers with combined expertise in South Asian health, prevention intervention trials, community engaged research, and implementation science, Dr. Shah proposes a comprehensive research and multidisciplinary career development plan composed of formal coursework, intensive mentorship, and experiential training in cohort management and community engagement in health disparity populations, advanced statistical methods for multi-level associations, genomics, and implementation science. The Specific Aims are to: (1) pilot the MASALA-2G study of cardiovascular health in 2nd generation SA adults age 21-40 years, who are offspring of MASALA parent study participants; (2) determine multi-level contributors to cardiovascular health and coronary artery calcium in MASALA-2G participants; and (3) contextualize a cardiovascular health promotion behavioral intervention for this population based on quantitative findings, following the Intervention Mapping framework. The proposed research and training will occur at Northwestern University, which provides Dr. Shah with: (1) access to unparalleled infrastructure and partnerships for research in the South Asian community, (2) a multidisciplinary team of mentors and collaborators with comprehensive relevant expertise, (3) strong institutional support from the Division of Cardiology and Department of Preventive Medicine, and (4) training opportunities including in Northwestern’s Center for Community Health, Center for Global Cardiovascular Health, and Clinical and Translational Sciences Institute. Ultimately, this research and career development will enable Dr. Shah’s transition to independent research for cardiovascular prevention in South Asian populations.

项目概要/摘要 该职业发展奖将为 Nilay Shah 博士提供作为独立人士发展的机会 南亚裔美国人社区和临床心血管疾病预防研究员 人口，并以他在人口流行病学和临床心血管医学方面的经验为基础。 亚洲人的动脉粥样硬化性心血管疾病 (ASCVD) 负担不成比例地较高 与其他种族/族裔群体相比，年龄较小，但对先前的心血管健康状况知之甚少 向第二代年轻的南亚裔美国人提供有关这种风险的早期生命预防策略 拟议的应用程序旨在试点 MASALA-2G，即南方多层次评估。 亚洲动脉粥样硬化生命历程（第二代后代研究），一项针对动脉粥样硬化调节因子的后代研究 居住在美国的南亚人 (MASALA) 队列中的动脉粥样硬化主要是第一代 MASALA-2G 代表了对南亚移民心血管健康的基础研究。 南亚裔美国人人口，并与国家心肺血液研究所直接合作 促进不同人群预防心脏病的使命和目标。 Namratha Kandula 博士和 Mark Huffman 博士的指导，他们是联合研究的领先研究人员 南亚健康、预防干预试验、社区参与研究和 实施科学，沙阿博士提出全面的研究和多学科职业 发展计划由正式课程、强化指导和队列体验培训组成 健康差异人群的管理和社区参与，先进的统计方法 多层次协会、基因组学和实施科学的具体目标是： (1) 试点 MASALA-2G 对 21-40 岁第二代 SA 成年人（后代的后代）心血管健康的研究 MASALA 家长研究参与者；(2) 确定心血管健康和冠状动脉的多层次贡献者 MASALA-2G 参与者的动脉钙；(3) 将心血管健康促进行为置于背景中 根据干预映射框架，基于定量结果对该人群进行干预。 拟议的研究和培训将在西北大学进行，该大学为 Shah 博士提供：(1) 获得南亚社区无与伦比的基础设施和研究伙伴关系，(2) 由具有全面相关专业知识的导师和合作者组成的多学科团队，（3）强大 心脏病科和预防医学科的机构支持，以及（4）培训 机会包括西北大学社区健康中心、全球心血管中心 最终，健康、临床和转化科学研究所将实现这一研究和职业发展。 使 Shah 博士能够转向南亚人群心血管预防的独立研究。