Scientific Core

科学核心

基本信息

批准号：
10227135
负责人：
Kiran Bhaskar
金额：
$ 22.97万
依托单位：
UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10227135
关键词：
Address Affect Aging Alzheimer&apos s Disease Alzheimer&apos s disease diagnostic Alzheimer&apos s disease related dementia Alzheimer’s disease biomarker American Indians Amyloid Amyloid beta-Protein Area Award Biological Assay Biological Markers Blood Cancer Center Caucasians Clinical Services Communities Country Data Dementia Deposition Diagnosis Diffusion Magnetic Resonance Imaging Disease Education Funding Future Goals Grant Image Impaired cognition Incidence Inflammatory Institution Latino Lead Leukoaraiosis Liquid substance Magnetic Resonance Imaging Measurement Metalloproteases Methods Nerve Degeneration New Mexico Pathway interactions Patients Pattern Phase Play Population Populations at Risk Predictive Analytics Protocols documentation Research Research Personnel Resources Risk Rural Sampling Scientist Services Socioeconomic Status Standardization Stratification Technology Testing United States United States National Institutes of Health Universities Vascular Dementia Vascular Diseases base biomarker panel blood-brain barrier permeabilization cerebrovascular clinical Diagnosis cohort contrast enhanced data sharing dementia risk endophenotype health care availability health disparity imaging capabilities imaging modality improved innovation neuroimaging new technology novel novel marker outreach patient population programs racial and ethnic racial diversity ranpirnase rural Americans screening socioeconomics study population tau Proteins tool urban Native American white matter

项目摘要

PROJECT SUMMARY – Scientific Core In support of the New Mexico Exploratory Alzheimer’s Disease Research Center (NM eADRC), the Scientific Core will centralize and expand existing expertise on Alzheimer’s disease biomarker research to the rural and urban American Indian (AI) communities in New Mexico. Specifically, the Scientific Core will establish ADNI- compatible, cerebrovascular focused neuroimaging, standardized assays for Aβ, tau and matrix metalloproteases (MMPs) in the blood and CSF samples and developing predictive analytics to distinguish different dementias in the rural and urban AI communities. Additional goals of the Scientific Core are to co- ordinate with the administrative core to have the biomarker data deposited to NACC and NCRAD, provide services to qualified investigators at University of New Mexico, across different institutions in the state and from other ADRCs/institutions across the nation. The Scientific Core also propose to expand the pool of dementia researchers by patterning with other centers/signature programs at the UNM and initiating new pilot programs on novel biomarkers/pathways related to Alzheimer’s disease and related disorders (AD/ADRD) research. The Scientific Core will support the NM eADRC to address one of the most important aspects of National Alzheimer’s Project Act on health disparities by successfully performing endophenotyping of the ‘at risk’ AI cohort. These goals will improve the limited screening clinical services available for dementia risk in AI population and also increase the representation of AI population in dementia research. These goals will be achieved by the Scientific Core under three specific aims. Aim 1: To provide expertise in magnetic resonance imaging (MRI) methods for understanding vascular contributions to dementia in Alzheimer’s disease and related disorders. Aim 2. To establish standardized assays for blood and CSF biomarker measurements for the dementia diagnosis and to develop and develop/test novel biomarkers that are currently used in the NIH- funded multi-center MarkVCID consortium study. Aim 3: Lead, coordinate, and develop dementia research across UNM and around the state via partnerships and pilot grant funding to carryout AD/ADRD research. Impact: Successful completion of all three specific aims of the Scientific Core will address one of the important gaps of test establish relationship across diverse racial, ethnic and socioeconomic backgrounds for dementia research, expand dementia research in NM and thus be ready for the P30 phase of ADRC in New Mexico in the near future.

项目摘要——科学核心为了支持新墨西哥州探索性阿尔茨海默病研究中心 (NM eADRC)，科学 Core 将集中并将现有的阿尔茨海默病生物标志物研究专业知识扩展到农村和农村地区。具体来说，科学核心将在新墨西哥州建立 ADNI- 城市美洲印第安人 (AI) 社区。兼容的脑血管聚焦神经影像、Aβ、tau 和基质标准化检测血液和脑脊液样本中的金属蛋白酶 (MMP) 并开发预测分析来区分科学核心的其他目标是共同应对农村和城市人工智能社区的不同痴呆症。与行政核心协调，将生物标志物数据存入 NACC 和 NCRAD，提供为新墨西哥大学、该州不同机构的合格研究人员提供服务全国其他 ADRC/机构也建议扩大痴呆症的范围。研究人员通过与新墨西哥州其他中心/签名项目进行模式合作并启动新的试点项目与阿尔茨海默病和相关疾病 (AD/ADRD) 研究相关的新型生物标志物/通路。科学核心将支持 NM eADRC 解决国家战略最重要的方面之一阿尔茨海默病项目通过成功对“高危”人工智能进行内表型分析来解决健康差异这些目标将改善人工智能中痴呆症风险的有限筛查临床服务。人口并增加人工智能人口在痴呆症研究中的代表性。科学核心根据三个具体目标实现：提供磁共振方面的专业知识。成像 (MRI) 方法可了解血管对阿尔茨海默氏病痴呆的影响目标 2. 建立血液和脑脊液生物标志物测量的标准化检测方法。痴呆症诊断以及开发和开发/测试目前在 NIH 中使用的新型生物标志物资助多中心 MarkVCID 联盟研究目标 3：领导、协调和发展痴呆症研究。通过合作伙伴关系和试点拨款资助，在新墨西哥州和全州各地开展 AD/ADRD 研究。影响：成功完成科学核心的所有三个具体目标将解决其中一个重要问题测试差距建立了不同种族、民族和社会经济背景之间痴呆症的关系研究，扩大新墨西哥州的痴呆症研究，从而为新墨西哥州 ADRC 的 P30 阶段做好准备不久的将来。