NRSA Training Core

NRSA 培训核心

• 批准号: 10398854
• 负责人: Thomas Michel
• 金额: $ 72.4万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10398854
• 关键词: Active Learning; Basic Science; Bioinformatics; Biological; Biological Sciences; Biology; Biomedical Research; Boston; Chemicals; Chemistry; Clinical; Clinical Medicine; Clinical Sciences; Communities; Complement; Diagnosis; Discipline; Disease; Doctor of Philosophy; Educational Curriculum; Faculty; Foundations; Funding; Future; Goals; Human Biology; Immunology; Infrastructure; Leadership; Mentors; Methodology; Methods; National Research Service Awards; Neurosciences; Patients; Physicians; Prevention; Research; Science; Students; Systems Biology; TNFSF15 gene; Time; Training; Training Programs; Training Support; Translational Research; Translations; Universities; Workforce Development; base; career; catalyst; experience; graduate student; human disease; learning strategy; programs; translational medicine

The Harvard Catalyst (HC) TL1 Training Program provides the organizational, curricular, and intellectual infrastructure for creating and mentoring a community of students and faculty engaged in disease-oriented research and the translation of principles of human biology to clinical medicine. TL1 offers an interdisciplinary PhD program that integrates human biology and translational medicine training for graduate students in life sciences graduate programs across Harvard University (HU). For the past nine years, the TL1 Program has provided a cornerstone of support for some of the best graduate students in the Leder Human Biology Program (LHB Program). TL1 currently supports 39 students, integrated in the larger community of 78 students in the LHB program. Students in the TL1 program come from graduate programs across Harvard University, including Biological and Biomedical Sciences, Neurosciences, Immunology, Systems Biology, and Chemistry and Chemical Biology. The two TL1 Co-Leads, Connie Cepko, PhD, and Thomas Michel, MD, PhD, have extensive and complementary expertise in basic, translational, and clinical science, and longstanding experience in the leadership of graduate training programs. Going forward, TL1 will continue to represent a key component of the HC Translational Workforce Development (see Core D. Translational Endeavors). TL1 will expand to incorporate new training programs in team science, quantitative methods, and bioinformatics that complement current programs to prepare an effective biomedical research workforce of the future. Each year TL1 will select seven new first-year graduate students. The average time to obtaining the PhD degree for TL1 students is 5.7 years. Awardees will be supported for the first two years of their PhD studies, after which support will come from their PhD mentors' research program, or from institutional funds or foundations. The objectives of the TL1 Training Core are to: (Aim 1) Provide a graduate curriculum with a focus on quantitative team-based active learning methods that will train graduate students in the mechanisms and methodologies of human biology and disease-oriented T0/T1 discovery, and provide them with direct clinical contact with patients and physicians; (Aim 2) Establish a context for human disease-oriented translational research in paracurricular activities across HC that connect clinical medicine with student research in human biology and translational medicine; and (Aim 3) Nurture a diverse community of students and faculty with shared goals of applying rigorous methodologies to the translation of basic discoveries to prevention, diagnosis, and treatment of human disease, while also reaching out into the broader Boston community. TL1 will select and support the training of the best graduate students committed to careers in human biology and translational medicine, and who will benefit from and contribute to the discipline at HU and beyond.

哈佛催化剂 (HC) TL1 培训计划提供组织、课程和知识方面的培训 创建和指导从事疾病导向的学生和教师社区的基础设施 研究以及将人类生物学原理转化为临床医学。 TL1 提供跨学科 为研究生在生活中提供人类生物学和转化医学培训的博士项目 哈佛大学 (HU) 的科学研究生项目。在过去的九年里，TL1 计划已 为莱德人类生物学项目中一些最优秀的研究生提供了支持 （LHB 计划）。 TL1 目前支持 39 名学生，融入到由 78 名学生组成的更大社区中 LHB 计划。 TL1 项目的学生来自哈佛大学的研究生项目， 包括生物和生物医学科学、神经科学、免疫学、系统生物学和化学 和化学生物学。两位 TL1 联合负责人 Connie Cepko 博士和 Thomas Michel 医学博士、哲学博士 在基础科学、转化科学和临床科学方面拥有广泛且互补的专业知识，并且长期存在 领导研究生培训项目的经验。 展望未来，TL1 将继续代表 HC 翻译团队的关键组成部分 发展（参见核心 D. 转化努力）。 TL1 将扩展以纳入新的培训计划 团队科学、定量方法和生物信息学补充了当前的计划，以准备 未来有效的生物医学研究队伍。每年 TL1 都会选出七名新一年级毕业生 学生。 TL1学生获得博士学位的平均时间为5.7年。获奖者将是 为他们的博士学习的前两年提供支持，之后将获得他们的博士导师的支持 研究计划，或来自机构基金或基金会。 TL1 培训核心的目标是：（目标 1）提供研究生课程，重点关注 基于团队的定量主动学习方法，将培训研究生的机制和 人类生物学方法论和面向疾病的T0/T1发现，并为他们提供直接的临床 与患者和医生接触； （目标 2）建立以人类疾病为导向的转化的背景 HC 的课外活动研究，将临床医学与学生人类研究联系起来 生物学和转化医学； （目标 3）培养多元化的学生和教师社区 应用严格的方法将基本发现转化为预防的共同目标， 诊断和治疗人类疾病，同时也接触到更广泛的波士顿社区。 TL1 将选择并支持培养致力于人类生物学职业的最优秀研究生 和转化医学，以及谁将从HU及其他学科中受益并为其做出贡献。