Training Interdisciplinary Pharmacology Scientists (TIPS)

培训跨学科药理学科学家（TIPS）

• 批准号: 10398794
• 负责人: Carmen W. Dessauer
• 金额: $ 23.56万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10398794
• 关键词: Pharmacology; Scientist; Training

PROJECT SUMMARY / ABSTRACT Training Interdisciplinary Pharmacology Scientists (TIPS) will train predoctoral students to address critical issues in drug development, by providing them the tools and knowledge to navigate the ever- changing, interdisciplinary landscape that makes up today’s basic, translational, and clinical research. This integrated T32 program is designed to create leaders in the broadly defined field of Pharmacological Sciences. TIPS will provide interdisciplinary training in drug development including screening, computation, medicinal chemistry, and structural biology relevant to target discovery and validation, and an understanding of regulatory issues involved in advancing candidate therapeutics to clinical application. Through the participation of 3 premier and neighboring biomedical research institutions and their graduate schools (University of Texas Health Science Center at Houston, Baylor College of Medicine, and Rice University), TIPS will provide interdisciplinary training, career development activities and industry shadowships that will prepare students to advance biomedical research through successful careers in academia, government and regulatory agencies, and industry. Program leadership includes the program director and co-director and a steering committee of representatives from the participating graduate programs, along with an external advisory committee of diverse experts. TIPS program requirements and benefits will include co-mentoring from two faculty in a collaborative research project; specific didactic and elective courses (available to TIPS trainees at all participating schools); monthly trainee meetings to build a unified cohort; a wide variety of career development activities, and required training in the responsible conduct of research and rigor and reproducibility. Mentors will include 31 faculty members at 3 institutions, working in 14 graduate programs, who have training and research expertise in drug/compound screening, pharmacology, computation, medicinal chemistry, structural biology, systems biology, biochemistry, genetics, and molecular and cellular biology. All participating departments recruit nationwide, especially for students of diverse backgrounds who are under-represented in the biomedical sciences, including individuals with disabilities, from disadvantaged backgrounds, and from under-represented racial and ethnic groups. This provides a large, diverse pool of predoctoral students from a variety of backgrounds for our 5 requested slots. Students will apply to TIPS after joining a lab near the end of their first year or during their second year of graduate school, and if selected through a holistic application process, will receive two years of support. Reappointment to a second year will be contingent on a thorough oral and written review of trainee research progress and completion of program requirements. TIPS will complement the degree requirements of a trainee’s home institution, causing no delay in degree completion. The interdisciplinary skills emphasized by this program will produce pharmacology scientists well positioned to advance biomedical research and to address the complexity of drug development.

项目概要/摘要 培训跨学科药理学科学家（TIPS）将培训博士前学生解决 药物开发中的关键问题，通过为他们提供工具和知识来应对不断变化的问题 不断变化的跨学科格局构成了当今的基础、转化和临床研究。 综合 T32 计划旨在培养广泛定义的药理学科学领域的领导者。 TIPS 将提供药物开发方面的跨学科培训，包括筛选、计算、医学 与目标发现和验证相关的化学和结构生物学，以及对 通过参与将候选疗法推进临床应用涉及监管问题。 3 个一流和邻近的生物医学研究机构及其研究生院（德克萨斯大学 休斯顿健康科学中心、贝勒医学院和莱斯大学），TIPS 将提供 跨学科培训、职业发展活动和行业实习，帮助学生做好准备 通过在学术界、政府和监管机构取得成功的职业发展进行生物医学研究， 项目领导层包括项目主任和联合主任以及指导委员会。 来自参与研究生项目的代表，以及来自不同领域的外部咨询委员会 TIPS 计划的要求和好处将包括两名教师的共同指导。 研究项目；具体的教学和选修课程（所有参与学校的 TIPS 学员均可使用）； 每月举行学员会议，以建立统一的团队；以及所需的各种职业发展活动； 负责研究行为以及严谨性和可重复性方面的培训将包括 31 名教师。 3 个机构的成员，从事 14 个研究生项目，他们在以下领域拥有培训和研究专业知识 药物/化合物筛选、药理学、计算、药物化学、结构生物学、系统 生物学、生物化学、遗传学以及分子和细胞生物学所有参与部门都招收学生。 全国范围内，特别是对于生物医学领域代表性不足的不同背景的学生 科学，包括来自弱势背景和代表性不足的残疾人 这提供了来自不同种族和民族的大量、多样化的博士前学生。 学生将在第一个实验即将结束时申请 TIPS。 年或研究生院第二年，如果通过整体申请流程选择，将 获得两年的支持将取决于全面的口头和书面支持。 对实习生研究进展和项目要求完成情况的审查将补充 TIPS。 学员所在院校的学位要求，不会导致学位完成延迟。 该计划强调的跨学科技能将培养药理学科学家，使他们能够 生物医学研究并提高药物开发的复杂性。