Administrative Core

行政核心

• 批准号: 10220699
• 负责人: David H. O'Connor
• 金额: $ 27.5万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10220699
• 关键词: Administrator; Americas; Animals; Arbitration; Biological; Charge; Collaborations; Communication; Communication Tools; Communities; Complex; Dangerousness; Development; Disputes; Doctor of Philosophy; Ensure; Equipment and supply inventories; Experimental Designs; Fetus; Functional disorder; Goals; Health Personnel; Human Resources; Infection; Institution; International; Intranet; Lead; Leadership; Natural Immunity; Participant; Policies; Pregnancy; Pregnant Women; Progress Reports; Protocols documentation; Reporting; Research; Research Personnel; Risk; Sampling; Scientist; Shipping; Students; System; Time; Training; United States National Institutes of Health; Vaccination; Vertebrates; Viremia; Work; ZIKA; Zika Virus; conflict resolution; congenital zika syndrome; data sharing; experience; meetings; member; neonate; programs; tool

Admin Core - Project Summary/Abstract The rapid and explosive spread of Zika virus has lead to the recognition that infection during pregnancy can lead to congenital Zika syndrome. The key hypothesis of this Program Project is that prolonged maternal viremia during pregnancy predicts the risk of congenital Zika syndrome. We will explore this hypothesis through three integrated projects. The Administrative (Admin) Core is charged with coordi- nating activities of the entire Program Project to ensure timely and efficient completion of the overall scientific goals. The activities of the Admin Core are broadly divided into five Specific Aims: Specific Aim 1. Coordinating communications between all participants. Specific Aim 2. Ensuring and maintaining regulatory compliance. Specific Aim 3. Managing program finances and overseeing subawards. Specific Aim 4. Enforcing policies pertaining to scientific rigor, transparency, data sharing, and con- flict resolution. Specific Aim 5. Promoting professional development of students and junior scientists participating in this Program Project. ZIKV is dangerous to pregnant women and their fetuses/neonates throughout the Americas. This risk will persist for at least several years, even if it is eventually curtailed by natural immunity and widespread vaccination. The Admin Core will coordinate all the Projects to ensure completion of all the scientific goals, providing important new tools for pregnant women and their healthcare providers to assess, and potentially reduce, the risk of congenital Zika syndrome.

管理核心 - 项目摘要/摘要 寨卡病毒的快速和爆炸性传播使人们认识到妊娠期间感染 可导致先天性寨卡综合症。该计划项目的关键假设是长期 怀孕期间母体病毒血症可预测先天性寨卡综合征的风险。我们将探讨这个 通过三个综合项目进行假设。行政（Admin）核心负责协调 统筹安排整个计划项目的活动，确保按时、高效地完成总体计划 科学的目标。管理核心的活动大致分为五个具体目标： 具体目标 1. 协调所有参与者之间的沟通。 具体目标 2. 确保并维持法规遵从性。 具体目标 3. 管理计划财务并监督子奖项。 具体目标 4. 执行有关科学严谨性、透明度、数据共享和控制的政策 冲突解决。 具体目标 5. 促进参与的学生和青年科学家的专业发展 本计划项目。 ZIKV 对整个美洲的孕妇及其胎儿/新生儿都是危险的。这种风险 即使它最终被自然免疫力和广泛传播所抑制，它也会持续至少几年 疫苗接种。管理核心将协调所有项目，以确保完成所有科学调查 目标，为孕妇及其医疗保健提供者提供重要的新工具进行评估，以及 可能降低先天性寨卡综合症的风险。