An Examination of Brown Adipose Tissue and Energy Expenditure in Infants

婴儿棕色脂肪组织和能量消耗的检查

• 批准号: 10388661
• 负责人: Emily W Flanagan
• 金额: $ 7.09万
• 依托单位: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10388661
• 关键词: Adipose tissue; Adult; Affect; Anatomy; Attenuated; Biomedical Research; Birth; Birth Weight; Body mass index; Brown Fat; Characteristics; Clinical Trials; Clinical assessments; Data; Data Collection; Development; Differentiation and Growth; Energy Metabolism; Environment; Equilibrium; Fatty Acids; Fatty acid glycerol esters; Fellowship; Female; Funding; Future; Glucose; Goals; Growth; Histologic; Human; Individual; Infant; Knowledge; Learning; Life; Lipids; Magnetic Resonance Imaging; Maternal Health; Measurement; Measures; Mentors; Methodology; Methods; Mothers; Neonatal; Obesity; Organ; Phenotype; Physiologic Thermoregulation; Physiological; Physiology; Pregnancy; Pregnant Women; Prenatal care; Principal Investigator; Property; Publications; Randomized; Research; Research Personnel; Research Training; Rest; Role; Signal Transduction; Supraclavicular; Testing; Thermogenesis; Thinness; Time; Tissues; Training; United States National Institutes of Health; Water; career; design; energy balance; experience; fetal; gestational weight gain; global health; group intervention; in utero; intrauterine environment; lifestyle intervention; male; natural hypothermia; neonate; newborn adiposity; novel; obesity in children; obesity risk; offspring; postnatal; prenatal; prenatal intervention; prepregnancy; programs; response; sex; skills; training opportunity; transmission process; treatment as usual; weight maintenance

PROJECT SUMMARY The developmental origins of obesity begin in utero with growth and differentiation of adipose tissue. Fetal white adipose tissue accretion is highly variable and dependent on the maternal intrauterine environment. Unlike white adipose tissue, brown adipose tissue (BAT) has a high capacity for thermogenesis. BAT is present at birth and it is believed to support the critical function of thermoregulation in early postnatal life. Therefore, BAT may also influence the development of neonatal energy balance. Similar to white adipose tissue, it is hypothesized that development of BAT in utero is also influenced by maternal factors such as prepregnancy BMI and gestational weight gain. The overall research aims of this mentored F32 fellowship are to 1) identify maternal and neonatal factors that contribute to neonatal BAT and 2) to identify changes in neonatal BAT and to energy expenditure in response to a mild cold exposure. These aims will be accomplished by leveraging the NIH funded clinical trial of Dr. Leanne Redman (primary mentor) Healthy Mamas (R01DK124806). The long-term goal of the candidate is to develop an independent research program that focuses on the developmental origins of energy balance. To achieve this goal, the primary training objectives are to: 1) develop skills in clinical trial management and data collection for neonates and grantsmanship, 2) acquire theoretical and practical expertise in brown adipose tissue identification (anatomy) and activation (physiology) methodology, and, 3) acquire didactic and hands-on training in the physiology, clinical assessment, and interpretation of human energy expenditure. The research and training will take place at Pennington Biomedical Research Center, an exceptional research environment that offers endless opportunities and will be sponsored by world leaders in the field of energy balance: Drs. Leanne Redman (maternal energy balance), Eric Ravussin (energy expenditure), and Denis Blondin (BAT). Successful completion of this proposal will result in several first-authored publications and will generate a wealth of preliminary data for a competitive K01 application. This F32 proposal will not only serve as a valuable training opportunity to incorporate a balance of didactic, hands-on, and mentor directed learning, but also a novel and meaningful scientific contribution. This proposed fellowship provides the candidate with the opportunity to begin training as a developmental energy balance researcher and to launch an independent academic career.

项目概要 肥胖的发育起源始于子宫内脂肪组织的生长和分化。胎 白色脂肪组织的增生变化很大，并且取决于母亲的宫内环境。 与白色脂肪组织不同，棕色脂肪组织（BAT）具有较高的生热能力。最佳可行技术是 它在出生时就存在，并且被认为支持产后早期体温调节的关键功能。 因此，BAT也可能影响新生儿能量平衡的发育。与白色脂肪相似 组织，推测子宫内 BAT 的发育也受到母体因素的影响，例如 如孕前 BMI 和妊娠期体重增加。此次指导的F32的总体研究目标 研究金的目的是 1) 确定有助于新生儿 BAT 的孕产妇和新生儿因素，以及 2) 确定 新生儿 BAT 和因轻度寒冷暴露而产生的能量消耗的变化。这些目标将是 通过利用 NIH 资助的 Leanne Redman 博士（主要导师）健康临床试验来完成 妈妈（R01DK124806）。候选人的长期目标是开发独立的研究计划 重点关注能量平衡的发展起源。为了实现这个目标，首先要进行基础训练 目标是： 1) 培养新生儿和儿童的临床试验管理和数据收集技能 资助，2）获得棕色脂肪组织识别（解剖学）的理论和实践专业知识 和激活（生理学）方法，以及，3）获得生理学方面的教学和实践培训， 临床评估和人体能量消耗的解释。研究和培训将进行 彭宁顿生物医学研究中心拥有卓越的研究环境，提供无尽的研究成果 机会并将由能源平衡领域的世界领导人赞助：博士。莉安·雷德曼 （母亲能量平衡）、Eric Ravussin（能量消耗）和 Denis Blondin（BAT）。成功的 该提案的完成将产生多份第一作者的出版物，并将产生大量的成果 竞争性 K01 应用的初步数据。这个F32提案不仅可以作为一次有价值的培训 有机会将教学、实践和导师指导的学习相结合，同时也是一种新颖和 有意义的科学贡献。拟议的奖学金为候选人提供了机会 开始接受发展能量平衡研究员的培训并开始独立的学术生涯。