MOTOR AND COGNITIVE AGING IN A NONHUMAN PRIMATE MODEL

非人类灵长类动物模型中的运动和认知老化

• 批准号: 7715940
• 负责人: MARTHA NEURINGER
• 金额: $ 1.11万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715940
• 关键词: Address; Age; Aging; Circadian Rhythms; Clinical; Cognitive; Cognitive aging; Computer Retrieval of Information on Scientific Projects Database; Data; Dementia; Disruption; Elderly; Female; Funding; Future; Grant; Hormones; Human; Impaired cognition; Institution; Locomotion; Macaca mulatta; Measures; Memory; Modeling; Monitor; Motor; Motor Skills; Ovariectomy; Reaction Time; Research; Research Personnel; Resources; Short-Term Memory; Sleep; Sleep Fragmentations; Source; Technology; Testing; Training; United States National Institutes of Health; base; cognitive function; cohort; human study; memory recognition; neuromechanism; nonhuman primate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Human studies suggest that changes in motor function may accompany or predict cognitive decline and onset of dementia. Therefore monitoring of motor function may provide an early sign of incipient cognitive impairment. However, relationships among motor and cognitive function during aging are not well understood, and it is not clear which measures of motor function are best correlated or predictive of cognitive status. Furthermore, disruption of sleep and circadian rhythms is common in the elderly and may contribute to, or correlate with, both motor and cognitive impairment. Nonhuman primates provide an excellent model for testing these relationships as they have cognitive abilities most similar to humans and show similar trajectories of motor and cognitive decline with age. We have available a cohort of aging female rhesus monkeys that have been trained to perform several assessments of cognitive function and have generated longitudinal data as part of a study of ovariectomy and hormone replacement. They represent an extremely valuable resource that now can be used to address the relationships among measures of 1) different cognitive abilities, including spatial working memory and recognition memory, 2) motor function, including locomotion, fine motor skills, simple reaction time and 3) circadian activity and sleep fragmentation. We will also compare measures of activity, locomotion and motor function obtained with different technologies. The data are of immediate relevance to clinical researchers planning related human studies, and will provide the basis for future studies aimed at elucidating underlying neural mechanisms of aging and developing treatment strategies.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 人类研究表明，运动功能的变化可能伴随或预测痴呆症的认知能力下降和发作。因此，监测运动功能可能会提供初期认知障碍的早期迹象。但是，在衰老过程中运动和认知功能之间的关系尚不清楚，尚不清楚哪种运动功能的措施最能与认知状态相关或预测。此外，睡眠和昼夜节律的破坏在老年人中很常见，可能导致运动和认知障碍或认知障碍。非人类灵长类动物为测试这些关系提供了出色的模型，因为它们具有与人类最相似的认知能力，并且随着年龄的增长而显示出类似的运动和认知能力下降的轨迹。我们提供了一系列老化的雌性恒河猴，这些猴子经过训练，可以对认知功能进行多种评估，并产生了纵向数据，这是卵巢切除术和激素替代研究的一部分。它们代表了一种极为宝贵的资源，现在可以用来解决1）不同认知能力之间的关系，包括空间工作记忆和识别记忆，2）运动功能，包括运动，精细的运动技能，简单的反应时间和3）昼夜节律活动和睡眠碎片。我们还将比较使用不同技术获得的活动，运动和运动功能的度量。数据与计划相关人类研究的临床研究人员的直接相关，并将为旨在阐明衰老和制定治疗策略的基本神经机制的未来研究提供基础。