CALORIC RESTRICTION AND AGING IN NONHUMAN PRIMATE EYES

非人类灵长类动物眼睛的热量限制和衰老

• 批准号: 8173209
• 负责人: MARTHA NEURINGER
• 金额: $ 5.71万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173209
• 关键词: Address; Age; Aging; Atrophic; Caloric Restriction; Cataract; Cell physiology; Clinical; Computer Retrieval of Information on Scientific Projects Database; Development; Diet; Disease; Evaluation; Eye; Fishes; Funding; Glaucoma; Goals; Grant; Health; Human; Institutes; Institution; Intervention; Longevity; Macaca mulatta; Macular degeneration; Modeling; Monitor; Monkeys; Optic Nerve; Organ; Oxidative Stress; Research; Research Personnel; Resources; Retinal Diseases; Rodent; Source; United States National Institutes of Health; age related; fly; insight; nonhuman primate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Dietary caloric restriction (CR) is the only intervention to reliably extend the lifespan of a variety of species, including worms, flies, fishes and rodents. Whether CR can also extend the human lifespan remains unknown. The National Institutes of Aging's Caloric Restriction Study maintains long-term colonies of nonhuman primates that are evaluated for many health parameters and markers of aging and provide the best available nonhuman primate model to address this question. As part of this unique resource, groups of rhesus monkeys, including young and old groups on 30% calorically restricted or ad libitum diets, were maintained at ONPRC for 4.5 years, and large groups are being followed throughout their lifespan at NIA. Because of its accessibility to noninvasive monitoring, the eye is an ideal organ to evaluate longitudinally whether CR can retard the occurrence of aging and age-related disease, and therefore we are conducting in-depth studies of ocular aging in these monkeys. The two major goals of our project are: 1) to determine whether CR retards the development of aging and age-related ocular diseases including macular degeneration, cataract, glaucoma and optic nerve atrophy; and 2) to correlate clinical observations with histopathological studies, using markers of age-related degeneration and oxidative stress. This research can provide new insights into the causes and possible treatment of human age-related ocular disorders. In the past year we continued evaluation of monkeys in the NIA CR colony, and completed morphological studies that contribute to understanding the cellular processes involved in age-related retinal disease.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 饮食热量限制（CR）是可靠地延长多种物种（包括蠕虫、苍蝇、鱼类和啮齿动物）寿命的唯一干预措施。 CR是否也能延长人类寿命仍不得而知。美国国家老龄化研究所的热量 限制研究维持了非人类灵长类动物的长期群体，对这些群体的许多健康参数和衰老标志进行了评估，并提供了最佳的非人类灵长类动物模型来解决这个问题。作为这一独特资源的一部分，恒河猴群体（包括幼年和老年群体，饮食限制为 30% 或随意饮食）在 ONPRC 维持了 4.5 年，并且 NIA 会跟踪大量群体的整个生命周期。由于眼睛可以进行无创监测，因此是纵向评估CR是否可以延缓衰老和年龄相关疾病发生的理想器官，因此我们正在对这些猴子的眼衰老进行深入研究。我们项目的两个主要目标是：1）确定CR是否可以延缓衰老和与年龄相关的眼部疾病的发展，包括黄斑变性、白内障、青光眼和视神经萎缩； 2）利用年龄相关退化和氧化应激的标志物将临床观察与组织病理学研究联系起来。这项研究可以为人类与年龄相关的眼部疾病的原因和可能的治疗提供新的见解。 去年，我们继续对 NIA CR 群体中的猴子进行评估，并完成了形态学研究，这有助于了解与年龄相关的视网膜疾病相关的细胞过程。