Biomarker Core

生物标志物核心

• 批准号: 10378619
• 负责人: STEVEN E ARNOLD
• 金额: $ 30.19万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-15 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10378619
• 关键词: Address; Administrative Supplement; Alzheimer' s Disease; Alzheimer' s disease related dementia; Amyloid; Area; Biological; Biological Assay; Biological Markers; Blood; Blood Banks; Caring; Cerebrospinal Fluid; Classification; Clinical; Clinical Trials; Cohort Studies; Collaborations; Collection; Data; Databases; Demography; Development; Diagnosis; Disease; Distributional Activity; Education; Enzyme-Linked Immunosorbent Assay; Faculty; Functional disorder; Future; Heterogeneity; Image; Infrastructure; International; Knowledge; Laboratories; Marshal; Massachusetts; Measures; Mission; Molecular Diagnostic Testing; Molecular Disease; Monitor; Pathology; Pathway interactions; Patients; Performance; Persons; Plasma; Process; Prognosis; Quality Control; Research; Research Design; Research Personnel; Research Project Grants; Resources; Risk Factors; Sampling; Spinal Puncture; Staging; Standardization; Stratification; Students; Teacher Professional Development; Technology; Training; Training and Education; Validation; Venous blood sampling; Work; career development; clinical biomarkers; cohort; community center; comparative; disease prognosis; innovation; molecular diagnostics; neuropathology; novel; novel strategies; research data dissemination; sex; single molecule; targeted biomarker; tau Proteins; tau-1; tool; treatment response

Massachusetts Alzheimer’s Disease Research Center: Biomarker Core The Biomarker Core of the Massachusetts Alzheimer’s Disease Research Center (MADRC) supports and performs biofluid biomarker research to contribute to our understanding heterogeneity in Alzheimer’s disease and Alzheimer’s disease related disorders (AD/ADRD) and to accelerate progress towards a cure. We carry out core functions, marshaling resources to enhance the research mission through Aim 1's collection, curation and distribution activities for blood and cerebrospinal fluids (CSF) for MADRC, local and national research and Aim 2's standardized performance of essential molecular diagnostic assays of amyloid- b42 and tau to contribute to biological classification of AD/ADRDs in the MADRC Research Cohort and other samples. We develop and implement new strategies and accelerate progress towards a cure in Aim 3 and 4's refinement and validation of novel ELISA, Simoa, and MS assays targeting multiple pathophysiological pathways in blood and CSF, and in Aim 5's express focus on understanding those assays' utility for clinical and clinical trials settings. These novel approaches are piloted in the MADRC collections of blood and CSF spanning diverse AD/ADRD diagnoses, stages of disease, prognosis, demography (including sex as a biological variable), risk factors, heterogeneous pathophysiological drivers, and treatment. Successful pilot work and biofluid sample resources are then leveraged to facilitate larger focused research projects in and outside of the MADRC community. We build the future in Aim 6 by providing expertise, education, training and laboratory resources to faculty, trainees and students for best practices in biofluids biomarker research, and in Aim 7 by providing education to researchers, clinicians and the public on the advances, utility and responsible interpretation of biomarker data in ADRD research and ultimately how biomarkers can be used in caring for people with AD/ADRD.

马萨诸塞州阿尔茨海默病研究中心：生物标志物核心 马萨诸塞州阿尔茨海默病研究中心 (MADRC) 的生物标记核心支持并 进行生物流体生物标志物研究，有助于我们了解阿尔茨海默病的异质性 疾病和阿尔茨海默病相关疾病 (AD/ADRD) 并加速治愈进展。 我们履行核心职能，通过目标 1 整合资源来加强研究任务 为 MADRC、当地和地区开展血液和脑脊液 (CSF) 的收集、管理和分配活动 国家研究和 Aim 2 淀粉样蛋白基本分子诊断检测的标准化性能 b42 和 tau 有助于 MADRC 研究队列和其他研究中 AD/ADRD 的生物学分类 我们制定并实施新的策略，并加速实现目标 3 和目标的治愈进展。 4 针对多种病理生理学的新型 ELISA、Simoa 和 MS 检测的改进和验证 血液和脑脊液中的途径，以及 Aim 5 明确关注于了解这些测定在临床和临床中的效用 这些新方法在 MADRC 收集的血液和脑脊液中进行了试点。 涵盖不同的 AD/ADRD 诊断、疾病阶段、预后、人口统计学（包括性别作为 生物变量）、风险因素、异质病理生理驱动因素和治疗。 然后利用工作和生物流体样本资源来促进更大的重点研究项目 在 MADRC 社区之外，我们通过提供专业知识、教育和培训来构建目标 6 的未来。 为教师、学员和学生提供生物流体生物标志物研究最佳实践的实验室资源， 目标 7 为研究人员、超级明星和公众提供有关进步、实用性和 对 ADRD 研究中的生物标志物数据进行负责任的解释，以及最终如何将生物标志物用于 照顾 AD/ADRD 患者。