Developmental Biology of Neural Diseases

神经疾病的发育生物学

基本信息

批准号：
7615704
负责人：
Christopher Robert Kintner
金额：
$ 18.24万
依托单位：
SALK INSTITUTE FOR BIOLOGICAL STUDIES
依托单位国家：
美国
项目类别：
财政年份：
1995
资助国家：
美国
起止时间：
1995-09-29 至 2011-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7615704
关键词：
Developmental Biology Disease relating to nervous system

项目摘要

DESCRIPTION (provided by applicant): Many of the devastating diseases that afflict the human nervous system have their origins during embryonic development, when the mechanisms that give rise to cell type diversity and a complex tissue architecture go awry. In addition, the ability to repair damaged neural tissue in a clinical setting largely depends on a better understanding of the normal mechanisms that underlie brain and spinal cord development. Identifying these mechanisms and understanding their molecular bases is one of the most challenging problems in modern biology. The program proposed here is designed to address this challenge by producing doctorates trained in developmental biology with an emphasis on neural development. This training program is based on the rationale that the nervous system develops using elaborations on the same developmental principles and molecules that govern the formation of any multicellular organisms. Accordingly, trainees will engage in research and classroom education that will provide them with (1) a foundation in the principles of developmental biology, much of which stems from work in model organisms, (2) a training in developmental neurobiology, and (3) an exposure to emerging technologies that are likely to drive forward the field of experimental embryology.

描述（由申请人提供）：许多折磨人类神经系统的毁灭性疾病都起源于胚胎发育期间，当时产生细胞类型多样性和复杂组织结构的机制出现了问题。此外，在临床环境中修复受损神经组织的能力很大程度上取决于对大脑和脊髓发育基础正常机制的更好理解。识别这些机制并了解其分子基础是现代生物学中最具挑战性的问题之一。这里提出的计划旨在通过培养受过发育生物学（重点是神经发育）培训的博士学位来应对这一挑战。该培训计划的基本原理是，神经系统的发育是通过对控制任何多细胞生物体形成的相同发育原理和分子的阐述而实现的。因此，学员将参与研究和课堂教育，这将为他们提供（1）发育生物学原理的基础，其中大部分源于模型生物的工作，（2）发育神经生物学的培训，以及（3）接触可能推动实验胚胎学领域发展的新兴技术。

项目成果

期刊论文数量（24）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Efficiency of spermatogonial dedifferentiation during aging.

DOI：
10.1371/journal.pone.0033635
发表时间：
2012
期刊：
PloS one
影响因子：
3.7
作者：
Wong C;Jones DL
通讯作者：
Jones DL

Cell type-specific targeted mutations of Kras and Pten document proliferation arrest in granulosa cells versus oncogenic insult to ovarian surface epithelial cells.

DOI：
10.1158/0008-5472.can-08-3363
发表时间：
2009-08-15
期刊：
Cancer research
影响因子：
11.2
作者：
Fan HY;Liu Z;Paquet M;Wang J;Lydon JP;DeMayo FJ;Richards JS
通讯作者：
Richards JS

Loss of Fertility in the Absence of Progesterone Receptor Expression in Kisspeptin Neurons of Female Mice.

DOI：
10.1371/journal.pone.0159534
发表时间：
2016
期刊：
PloS one
影响因子：
3.7
作者：
Gal A;Lin PC;Cacioppo JA;Hannon PR;Mahoney MM;Wolfe A;Fernandez-Valdivia R;Lydon JP;Elias CF;Ko C
通讯作者：
Ko C

TRF2 interaction with Ku heterotetramerization interface gives insight into c-NHEJ prevention at human telomeres.