ISOFLAVONES IN PROSTATE CANCER UNDERGOING ANDROGEN DEPRIVATION THERAPY

接受雄激素剥夺治疗的前列腺癌中的异黄酮

• 批准号: 7604633
• 负责人: Shehzad Basaria
• 金额: $ 0.12万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604633
• 关键词: Agonist; Androgens; Castration; Cognition; Complication; Computer Retrieval of Information on Scientific Projects Database; Estrogen Replacement Therapy; Estrogen Therapy; Estrogens; Frequencies; Funding; Goals; Grant; Hot flushes; Hypogonadism; Institution; Isoflavones; Malignant neoplasm of prostate; Medical Castration; Memory; Menopausal hot flushes; Minority; Modeling; Orchiectomy; Osteoporosis; Patients; Performance; Plants; Postmenopause; Proteins; Quality of life; Radiation therapy; Radical Prostatectomy; Recurrence; Research; Research Personnel; Resources; Risk; Sexual Dysfunction; Source; United States National Institutes of Health; Woman; deprivation; improved; men; muscle strength

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this proposal is to investigate the effect of sy protein on cognition, quality of life and hot flashes in men with prostate cancer who are currently undergoing medical castration or have undergone surgical castration. Historically, radical prostatectomy and/or radiation therapy has been the mainstay of treatment in patients with locally confined PCa. However, for patients with metastatic PCa or those with a recurrence (detected by a rising PSA), androgen deprivation therapy (ADT) is frequently employed. The most common mode of ADT is the use of GnRH agonists which result in central hypogonadism (orchiectomy is performed in minority). Several complications of hypotestosteronemia have been described in men with hypogonadism. These include decline in lean body mass (LBM), muscle strength, osteoporosis, decrease in quality of life (QOL) and sexual dysfunction. Another complication of hypogonadism is hot flashes. This complication is seen with the highest frequency in men with PCa undergoing ADT (80-90% of the patients). Studies of postmenopausal women indicate that performance on tasks of memory improves following estrogen replacement therapy. Due to the potential risks involved with estrogen therapy, focus is being shifted to plant estrogens (isoflavones). Studying men with PCa proves the best model to evaluate the effects of isoflavones on cognition in men, while providing needed improvement in QOL. Furthermore, it may also result in an improvement in hot flashes.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该提案的总体目的是研究SY蛋白对目前正在接受医疗cast割或进行外科手术cast割的前列腺癌男性认知，生活质量和潮热的影响。 从历史上看，根治性的前列腺切除术和/或放射治疗一直是局部限制PCA患者的治疗中流tay。 但是，对于转移性PCA或患有复发的患者（由PSA检测到），经常使用雄激素剥夺疗法（ADT）。 ADT最常见的模式是使用GnRH激动剂，导致中枢性性不足（提供元切除术）。 患有性腺功能减退的男性已经描述了低溶性血症的几种并发症。 其中包括瘦体重（LBM）的下降，肌肉力量，骨质疏松症，生活质量降低（QOL）和性功能障碍。 性交的另一个并发症是潮热。 在患ADT的男性中，这种并发症的频率最高（占患者的80-90％）。 绝经后妇女的研究表明，在雌激素替代疗法后，对记忆任务的表现有所改善。 由于雌激素治疗涉及的潜在风险，重点正在转移到植物雌激素（异黄酮）。 研究患有PCA的男性证明了评估异黄酮对男性认知影响的影响的最佳模型，同时提供了QOL所需的改进。 此外，这也可能导致潮热的改善。