Mentoring in Endocrine and Cardiometabolic Abnormalities in Cancer and Aging

癌症和衰老中内分泌和心脏代谢异常的指导

• 批准号: 10300180
• 负责人: Shehzad Basaria
• 金额: $ 18.48万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10300180
• 关键词: Address; Age; Aging; American; Androgens; Area; Award; Baltimore; Benefits and Risks; Boston; Cancer Burden; Capsicum; Cardiometabolic Disease; Caring; Clinical; Clinical Research; Clinical Trials; Colorectal Cancer; Data; Deposition; Deterioration; Diabetes Mellitus; Diagnosis; Disease; Endocrine; Endocrine System Diseases; Endocrinologist; Endocrinology; Enrollment; Environment; Erythropoiesis; Faculty; Fatigue; Fatty Liver; Fatty acid glycerol esters; Fostering; Functional disorder; Funding; General Population; Geriatrics; Goals; Grant; Health; High Prevalence; Hospitals; Hypogonadism; Incidence; Infiltration; Inflammation; Infrastructure; Institution; Insulin Resistance; International; Investigation; K-Series Research Career Programs; Lead; Longitudinal Studies; Lower Extremity; Magnetic Resonance Spectroscopy; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of prostate; Measures; Medical; Medicine; Mentors; Mentorship; Metabolic; Metabolic syndrome; Metabolism; Metastatic Prostate Cancer; Mid-Career Clinical Scientist Award (K24); Morbidity - disease rate; Muscle; Oncology; Participant; Physical Function; Physical Performance; Prostate; Research; Research Institute; Research Personnel; Research Support; Resources; Role; Science; Series; Skeletal Muscle; Testosterone; Thinness; Time; Tissues; Training; Translational Research; United States; United States National Institutes of Health; Upper Extremity; Urology; Woman; Work; age related; androgen deprivation therapy; cardiometabolic risk; cardiometabolism; career; clinical center; clinical investigation; cytokine; disabling symptom; frailty; improved; interest; medical schools; medical specialties; men; mid-career faculty; multidisciplinary; muscle form; muscle strength; next generation; novel; older men; patient oriented research; programs; prospective; prostate cancer survivors; reduced muscle strength; side effect; skills

PROJECT SUMMARY Shehzad Basaria, MD, an Associate Professor of Medicine and Endocrinology in the Division of Endocrinology, Diabetes, & Metabolism at Brigham and Women's Hospital, Harvard Medical School, submits this application for a K24 Mid-Career Development award to provide protected time to mentor trainees in Patient-Oriented Research (POR) in Endocrine aspects of Gero-Oncology. Dr. Basaria is one of the few endocrinologists worldwide specializing in endocrine and cardio-metabolic disorders in older men with cancer and androgen deficiency. He will pursue additional training to hone his mentoring skills in order to build on his established record of mentorship and foster the research careers of early investigators. Candidate: Dr. Basaria is a highly productive clinical researcher in the field of Endocrinology, Aging and Cancer. Since 2003, he has been continuously NIH-funded to investigate: i) endocrine and cardio-metabolic complications of androgen deprivation therapy (ADT) in men with prostate cancer (PCa), ii) benefits and risks of androgen replacement in older men, and iii) endocrinology of aging. He has conducted his investigations using NIH-supported infrastructure, including RO1s and R21 grants, data from the Baltimore Longitudinal Study of Aging (BLSA), the InChianti Study, and the Boston Pepper Center for Function-Promoting Therapies. With his uncommon skill set and strong POR program in Endocrinology and Gero-Oncology, he has been a sought-after collaborator and mentor at Brigham/Harvard and at national and international institutions. Mentoring Plan/Environment: This application will leverage the extensive training resources at Brigham/Harvard, including the Center for Clinical Investigation, the Brigham Research Institute for Clinical and Translational Research, and T32 training grants in a variety of specialties. It will also draw on the unparalleled resources of the Boston Pepper Center and other funded studies to serve as a platform for POR trainees at multiple levels. Research Plan: The novel research supported by this K24 award will make significant contributions to the 1A) The impact of ADT-induced profound hypogonadism and the resulting decline in muscle mass on physical function, 1B) The impact of ADT on fat infiltration of skeletal muscles and the association of this deterioration in muscle quality on physical function, and 2) The mechanisms by which testosterone replacement improves Cancer- Related Fatigue in older men with cancer. understanding of the impact of androgen deficiency in older men with cancer in three major areas: These novel aims will build on the ongoing work in Dr. Basaria's current R01s, explore new hypotheses, and expand opportunities for trainees.

项目摘要 医学博士Shehzad Basaria医学博士，内分泌学系医学和内分泌学副教授， 哈佛医学院杨百翰和妇女医院的糖尿病和代谢，提交了此申请 获得K24中级发展奖，以提供受保护的学员的受保护时间 Gero肿瘤学内分泌方面的研究（POR）。巴萨里亚博士是为数不多的内分泌学家之一 全球专门从事癌症和雄激素老年男性的内分泌和心脏代谢疾病 不足。他将接受更多的培训以磨练他的指导技能，以便在他的既定 指导记录并培养早期研究人员的研究事业。 候选人：Basaria博士是内分泌，衰老和 癌症。自2003年以来，他一直被NIH资助进行调查：i）内分泌和心脏代谢 前列腺癌男性（PCA）的雄激素剥夺疗法（ADT）的并发症，ii）益处和风险 老年男性的雄激素替代，iii）衰老的内分泌学。他进行了调查 使用NIH支持的基础设施，包括RO1和R21赠款，来自巴尔的摩纵向的数据 衰老研究（BLSA），Inchianti研究和波士顿胡椒疗法中心。 凭借他在内分泌学和Gero-Concology方面的不常见技能和强大的POR计划，他一直是一个 在Brigham/Harvard以及国家和国际机构的合作者和导师寻求合作者和导师。 指导计划/环境：此应用程序将利用广泛的培训资源 杨百翰/哈佛大学，包括临床研究中心，杨百翰临床研究所 转化研究和T32培训赠款各种专业。它也将在无与伦比的 波士顿胡椒中心和其他资助的研究的资源，以作为POR受训者的平台 多个级别。 研究计划：该K24奖支持的新颖研究将为该研究做出重大贡献 1a） ADT引起的严重性能和肌肉质量对身体机能的影响， 1b）ADT对骨骼肌脂肪浸润的影响和这种恶化在肌肉中的关联 身体机能的质量，以及2）睾丸激素替代改善癌症的机制 - 老年男性患有癌症的相关疲劳。 了解雄激素缺乏对三个主要领域癌症老年男性的影响： 这些小说的目标将基于巴萨里亚博士的正在进行的工作 当前的R01，探索新的假设并扩大了学员的机会。