ADHD IN GIRLS: NEUROIMAGING AND EXECUTIVE BEHAVIOR

女孩多动症：神经影像和执行行为

• 批准号: 7604716
• 负责人: MARTHA BRIDGE DENCKLA
• 金额: $ 0.15万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604716
• 关键词: Accounting; Age; Anatomy; Attention deficit hyperactivity disorder; Basal Ganglia; Behavior; Behavioral; Cerebellar vermis structure; Cerebellum; Cerebrum; Child; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Control Groups; Data; Data Set; Emotional; Enrollment; Funding; Gender; Globus Pallidus; Grant; Inferior; Institution; Interview; Magnetic Resonance Imaging; Modeling; Motor; Neurobiology; Participant; Preparation; Range; Reading; Recruitment Activity; Research; Research Personnel; Research Project Grants; Resources; Short-Term Memory; Source; Staging; Symptoms; Testing; Thinking; United States National Institutes of Health; boys; brain behavior; executive function; experience; frontal lobe; girls; interest; neuroimaging; neuropsychological; oculomotor; response; skills; social

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is evidence that girls with ADHD differ from boys with ADHD most strikingly in 1) academic and social-emotional and 2) neurobiological features. Building upon previous research experience concerning neurobiological features of boys with ADHD, this research project focuses on 2) neurobiology of girls with ADHD, with plans to derive data from quantitative volumetric/anatomic magnetic resonance imaging (aMRI) and assessments of executive behaviors, both motor/oculomotor and cognitive. To take gender into account, girls with ADHD will be compared with control girls as well as boys with and without ADHD. The age range for the 200 participants (50 in each group) will be 9.0 to 11.5 years; in addition, even at this young age, Tanner staging will be taken into consideration. Anatomic MRI regions of interest will be frontal lobe, basal ganglia, and cerebellum. It is hypothesized that girls with ADHD will differ from boys with ADHD at the levels of frontal lobe (showing anomalous assymetry only), and at the level of the basal ganglia (showing symmetrically smaller total caudate and globus pallidus volumes) while sharing with boys total cerebral and posterior inferior vermis reductions. Behavioral tasks, motor/oculomotor as well as cognitive, will be categorized into inhibitory control, response preparation, and working memory, functions thought to represent parallel frontostriatal and cerebellar interlocking circuits. It is hypothesized that girls with ADHD will be relatively more impaired in terms of response preparation and working memory than in terms of inhibition, a profile opposite to that of boys with ADHD. Gender-by-subtype interactions with respect to aMRI and behavioral datasets and the impact of emotional symptoms will be analyzed. Brain-behavior relationships as influenced by gender (modified by covariates as noted above) will be interpreted in terms of neurodevelopmental models of ADHD. This is a five-year study, enrolling 200 children. We will recruit 50 boys and 50 girls with ADHD, and 50 boys and 50 girls in a normal control group. All participants will receive structural/anatomic MRI (emphasizing frontal lobes, basal ganglia, and cerebellum), neuropsychological assessment emphasizing executive functions (including motor/oculomotor assessment), IQ testing, assessment of basic reading skills, and psychiatric interview.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 有证据表明，患有多动症的女孩与ADHD男孩的不同，在1）学术和社会情感和2）神经生物学特征中最引人注目。 在以前有关ADHD男孩神经生物学特征的研究经验的基础上，该研究项目的重点是2）ADHD女孩的神经生物学，并计划从定量的体积/解剖/解剖学磁共振成像（AMRI）中获得数据，并评估执行行为，包括运动/动力/动力学和认知能力。 要考虑性别，患有多动症的女孩将与对照女孩以及有ADHD的男孩进行比较。 200名参与者的年龄范围（每组50名）为9.0至11.5岁；此外，即使在这个年轻的时候，也将考虑坦纳的分期。 感兴趣的解剖学MRI区域将是额叶，基底神经节和小脑。 假设ADHD的女孩与ADHD的男孩在额叶的水平（仅显示异常囊肿），并且在基底神经节的水平（表现出较小的总期权和Globus pallidus量），同时与男孩的总脑脑和后脑和后下部下部相同。 行为任务，电动机/动眼运动和认知能力将分为抑制性控制，响应准备和工作记忆，被认为代表平行的额叶和小脑互锁电路的功能。 假设患有多动症的女孩在响应准备和工作记忆方面比在抑制方面相对较高，这与ADHD男孩相反。 相对于AMRI和行为数据集的性别相互作用以及情绪症状的影响将被分析。 受性别影响的脑行为关系（如上所述，由协变量修改）将以ADHD的神经发育模型来解释。 这是一项为期五年的研究，招收了200名儿童。 我们将在一个正常对照组中招募50名男孩和50个患有多动症的女孩，50名男孩和50个女孩。 所有参与者都将获得结构/解剖学MRI（强调额叶，基底神经节和小脑），强调执行功能的神经心理学评估（包括运动/眼球运动评估），智商测试，基本阅读技能评估和精神访谈。