EFFECT OF EXERCISE TRAINING AFTER STROKE

中风后运动训练的效果

• 批准号: 7604718
• 负责人: DANIEL F HANLEY
• 金额: $ 0.02万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604718
• 关键词: Aerobic Exercise; Area; Auditory; Bilateral; Brain; Cerebrum; Computer Retrieval of Information on Scientific Projects Database; Controlled Study; Cues; Exercise; Functional Magnetic Resonance Imaging; Funding; Grant; Institution; Intervention; Leg; Limb structure; Lower Extremity; Measures; Motor; Movement; Muscle; Patient Selection; Patients; Pattern; Process; Recovery; Rehabilitation therapy; Research; Research Personnel; Residual state; Resources; Source; Stroke; Structure; Survivors; Training; United States National Institutes of Health; Upper arm; chronic stroke; hemiparesis; improved; stroke recovery

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are proposing a controlled study to investigate rehabilitation treatment-induced changes in brain activation patterns as a measure of cerebral plasticity in long-term stroke survivors. Two types of interventions will be investigated: Aerobic exercise (AEX) and Bilateral arm training with rhythmic auditory cueing (BATRAC). Both interventions involve the repetition of simple functional movements. Repetitive movements including arm or leg exercise training was shown to improve motor function in chronic stroke patients with residual upper or lower extremity Hemiparesis, even if employed 6-24 months after the disabling stroke. The mechanisms, by which these repetitive interventions improve limb function, are unknown. Functional magnetic resonance imaging (fMRI) can visualize changes in cortical representations of muscle groups and has the potential to elucidate some of the general mechanisms of AEX-improved stroke recovery. Besides gaining a better pathophysiologic understanding (Specific Aims 1 & 3), the identification of structures involved in the recovery process may guide patient selection (Specific Aim 2, e.g. if the initial stroke involves one of these critical areas, benefit from AEX or BATRAC may be minimal).

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们提出了一项对照研究，以研究康复治疗引起的脑激活模式的变化，以衡量长期中风幸存者的脑可塑性。 将研究两种类型的干预措施：有氧运动（AEX）和双边手臂训练具有节奏听觉提示（BATRAC）。 两种干预措施都涉及简单功能运动的重复。 即使在禁用中风后6-24个月使用，包括手臂或腿运动训练在内的重复运动（包括手臂或腿部运动训练）可改善慢性中风患者的运动功能。这些重复干预改善肢体功能的机制未知。功能磁共振成像（fMRI）可以可视化肌肉群的皮质表示的变化，并有可能阐明AEX改良中风恢复的某些一般机制。除了获得更好的病理生理学理解（特定目的1和3）之外，识别恢复过程中涉及的结构可以指导患者选择（特定目标2，例如，如果初始中风涉及这些关键领域之一，则会受益于AEX或BATRAC，可能是最小的）。