A Translational Approach to Evaluating the Effects of Physical Activity on ADHD

评估体力活动对多动症影响的转化方法

• 批准号: 8495508
• 负责人: JOHN T GREEN
• 金额: $ 8.47万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-08 至 2014-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8495508
• 关键词: Acute; Address; Adolescent; Adopted; Aerobic; Aerobic Exercise; Age; Agreement; Animals; Area; Attention; Attention deficit hyperactivity disorder; Auditory; Behavior; Behavior Therapy; Behavioral; Biological Assay; Birth; Brain; Brain-Derived Neurotrophic Factor; Characteristics; Child; Chronic; Clinical Psychology; Cognitive; Data; Disease; Dose; Evidence based treatment; Exercise; Family; Goals; Hippocampal Formation; Hippocampus (Brain); Human; Hyperactive behavior; Impairment; Impulsivity; Informal Social Control; Intervention; Kinesiology; Knowledge; Learning; Length; Measures; Motor; Movement; Neuronal Plasticity; Neurons; Neurosciences; Parents; Performance; Physical Fitness; Physical activity; Process; Proteins; Rattus; Regimen; Research; Risk; Rodent Model; Serum; Social Functioning; Societies; Structure; Symptoms; Time; Titrations; Visual; Work; base; behavior test; biobehavior; boys; dentate gyrus; evidence base; frontier; improved; inattention; motor deficit; neurogenesis; public health relevance; response; skills; social; teacher; translational approach; treatment effect

DESCRIPTION (provided by applicant): Even though the exact etiological mechanisms are not yet known, there is almost universal agreement that Attention-Deficit/Hyperactivity Disorder (ADHD) is a biologically-based disorder, involving impaired self- regulation and producing cognitive, motor, social and behavioral consequences. Evidence-based treatments for ADHD focus on reducing symptoms and impairments of the disorder either through pharmacological means, the use of behavioral therapy, or both. Effects from these treatments are difficult to maintain over time (Jensen et al., 2007), and behavioral treatments are viewed as burdensome to implement by some parents and teachers. Furthermore, despite its established efficacy, pharmacological intervention is controversial in society and is viewed as unacceptable to some families. Thus, the need for additional interventions, particularly those with the potential to offer new options to families and to address ADHD symptoms at the level of brain processes, remains pressing. Towards this end, we pursue an exciting new frontier in ADHD research involving the application of an aerobic physical activity intervention for addressing the disorder, as well as its associated impairments. We approach this goal from an interdisciplinary perspective, combining expertise in neuroscience, kinesiology and both biobehavioral and clinical psychology. Importantly, our preliminary work that is based both on a rodent model of ADHD and on human work with children suggests that aerobic physical activity reduces symptoms characteristic of ADHD. Therefore, we adopt a translational strategy, including both human and animal studies, to address five specific aims: First, we examine the effect of aerobic physical activity on hyperactivity/impulsivity and inattention as well as cognitive, motor, behavioral, and social functioning in young children (ages 5-8 yrs.) and young rats (approximately 40 days old) selected for the presence of ADHD or ADHD-like symptoms, respectively. Second, we examine the minimal length of physical activity intervention required to produce an effect. Third, we examine the persistence of these effects. Fourth, through animal work, we examine the most likely neural plasticity mechanisms that may underlie the effects of physical activity on hyperactivity/impulsivity and inattention through analysis of hippocampal neurogenesis and brain derived neurotrophic factor levels. PUBLIC HEALTH RELEVANCE: There is almost universal agreement that Attention-Deficit/Hyperactivity Disorder (ADHD) is a biologically- based disorder, involving impaired self-regulation and producing cognitive, motor, behavioral, and social consequences. We pursue an exciting new frontier in ADHD research, applying an aerobic physical activity intervention to address the disorder, as well as its associated impairments. We approach this goal from an interdisciplinary perspective, combining expertise in neuroscience, kinesiology, and both biobehavioral and clinical psychology.

描述（由申请人提供）：即使确切的病因机制尚不清楚，几乎可以普遍同意注意力缺陷/多动障碍（ADHD）是一种基于生物学的疾病，涉及自我调节受损并产生认知，运动，社会，社会和行为后果。基于循证的多动症治疗方法是通过药理学手段，使用行为疗法或两者兼而有之减少疾病的症状和损害。随着时间的流逝，这些疗法的影响很难维持（Jensen等，2007），行为治疗被视为繁重的某些父母和老师的实施。此外，尽管具有确定的功效，但药理学干预在社会中还是有争议的，对于某些家庭来说是无法接受的。因此，需要进行其他干预措施，尤其是那些有潜力为家庭提供新选择并在大脑过程水平上解决多动症症状的人的需求。为此，我们在多动症研究中追求令人兴奋的新领域，其中涉及有氧运动干预措施来解决该疾病及其相关障碍。我们从跨学科的角度实现了这一目标，结合了神经科学，运动学以及生物行为和临床心理学的专业知识。重要的是，我们的初步工作既基于多动症的啮齿动物模型，又基于与儿童的人类工作，这表明有氧运动可以减少ADHD的症状特征。 Therefore, we adopt a translational strategy, including both human and animal studies, to address five specific aims: First, we examine the effect of aerobic physical activity on hyperactivity/impulsivity and inattention as well as cognitive, motor, behavioral, and social functioning in young children (ages 5-8 yrs.) and young rats (approximately 40 days old) selected for the presence of ADHD or ADHD-like symptoms, respectively.其次，我们研究产生效果所需的体育活动干预的最小长度。第三，我们检查了这些影响的持久性。第四，通过动物工作，我们通过分析海马神经发生和脑部衍生的神经营养因子水平来研究最可能的神经可塑性机制，这些神经可塑性机制可能是体育活动对多动症/冲动性和注意力不集中的影响。 公共卫生相关性：几乎普遍同意注意力缺陷/多动症（ADHD）是一种基于生物学的疾病，涉及自我调节受损并产生认知，运动，行为和社会后果。我们在多动症研究中进行了令人兴奋的新领域，采用有氧运动干预来解决该疾病及其相关障碍。我们从跨学科的角度实现了这一目标，结合了神经科学，运动学以及生物行为和临床心理学的专业知识。