CARDIOVASCULAR RISK FACTORS IN WOMEN WITH PCOS

多囊卵巢综合征女性的心血管危险因素

• 批准号: 7604877
• 负责人: ANUJA DOKRAS
• 金额: $ 1万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604877
• 关键词: Affect; Atherosclerosis; Calcium; Complex; Computer Retrieval of Information on Scientific Projects Database; Coronary artery; Funding; Grant; Hypertension; Inflammatory; Institution; Insulin; Insulin Resistance; Metabolic syndrome; Metformin; Obesity; Ovarian; Ovulation Induction; Pharmaceutical Preparations; Population; Premenopause; Research; Research Personnel; Resources; Risk; Score; Source; Syndrome; United States National Institutes of Health; Weight; Woman; cardiovascular risk factor; impaired glucose tolerance; lipid disorder

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Polycystic ovarian syndrome (PCOS) is a complex syndrome affecting 5-10% of premenopausal women, with known associated risks of lipid disorders, insulin resistance, impaired glucose tolerance and hypertension. These investigators hypothesize that obese women with PCOS will have increased levels of inflammatory markers and evidence of atherosclerosis (as determined by higher coronary artery calcium scores) than weight-matched controls without PCOS. They will correlate these factors with the presence of the metabolic syndrome within this population. They also hypothesize that metformin, a drug commonly used in women with PCOS for its insulin sensitization and ovulation induction effects, will reduce levels of inflammatory markers in the obese PCOS women.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 多囊卵巢综合征 (PCOS) 是一种复杂的综合征，影响 5-10% 的绝经前女性，已知与血脂紊乱、胰岛素抵抗、糖耐量受损和高血压相关的风险。 这些研究人员假设，与体重匹配的非 PCOS 对照相比，患有 PCOS 的肥胖女性的炎症标志物水平和动脉粥样硬化证据（由较高的冠状动脉钙评分确定）会升高。 他们会将这些因素与该人群中代谢综合征的存在联系起来。 他们还假设二甲双胍（一种常用于 PCOS 女性的药物，具有胰岛素增敏和诱导排卵作用）将降低肥胖 PCOS 女性的炎症标志物水平。