BRAIN DEVELOPMENT OF ADOLESCENT MARIJUANA USERS

青少年大麻使用者的大脑发育

• 批准号: 7604855
• 负责人: ROBERT I BLOCK
• 金额: $ 3万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604855
• 关键词: Adolescence; Adolescent Development; Age; Blood flow; Brain; Cerebellum; Cerebrovascular Circulation; Child; Chronic; Cognition; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Development; Functional disorder; Funding; Gambling; Grant; Hippocampus (Brain); Human; Illicit Drugs; Individual; Institution; Iowa; Knowledge; Magnetic Resonance Imaging; Marijuana; Memory; Positron-Emission Tomography; Prefrontal Cortex; Records; Research; Research Personnel; Resources; Score; Societies; Source; Structure; Testing; United States National Institutes of Health; age effect; brain tissue; cost; neuroimaging

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research will examine the effects of age of first use of marijuana and duration of use on brain function, brain structure, and cognition. Considering that marijuana is the most widely used illicit drug, if chronic use produces brain dysfunction in some marijuana users and this dysfunction is greater in those who begin use earlier during adolescence and use longer, the potential costs to society could be high. Using positron emission tomography and magnetic resonance imaging, we will examine differences between chronic marijuana users and control subjects in baseline regional cerebral blood flow and cognition-related changes in regional cerebral blood flow (in memory, tapping and gambling tests), as well as whole brain blood flow and brain tissue volume and composition. We hypothesize that chronic marijuana users will differ from control subjects and these differences will be more pronounced in marijuana users with earlier ages of first use and longer durations of use. Hypothesized effects of chronic marijuana use on regional cerebral blood flow in posterior cerebellum, prefrontal cortex, and hippocampus are particular foci of the proposed research. If the hypothesized effects occur, they will provide evidence that chronic marijuana use alters brain functioning and that the pronounced brain development that normally occurs during adolescence increases vulnerability to such alterations. Additional, more extensive cognitive tests will be administered in sessions not involving neuroimaging to test the hypothesis that cognitive effects of marijuana use are also more pronounced in individuals with earlier ages of first use and longer durations of use. Groups of subjects will be matched on premorbid intellectual function using records of standardized test scores that are available for children educated in virtually all parts of Iowa. When completed, the proposed research will make important additions to knowledge about effects of chronic marijuana use on human brain function, brain structure, and cognition.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究将研究大麻和使用时间的首次使用年龄对脑功能，大脑结构和认知的影响。 考虑到大麻是使用最广泛使用的非法药物，如果长期使用在某些大麻使用者中会产生脑功能障碍，并且这种功能障碍在青春期开始使用并使用更长的人使用的人会更大，那么社会的潜在成本可能很高。 使用正电子发射断层扫描和磁共振成像，我们将检查慢性大麻使用者与基线区域脑血流中的受试者之间的差异，以及区域脑血流（记忆，敲击和赌博测试中的区域性脑血流中）的差异，以及全脑血液流量和大脑血流组织的体积和组成。 我们假设慢性大麻使用者将与控制对象有所不同，而这些差异将在早期使用和使用时间更长的大麻使用者中更为明显。 慢性大麻使用对拟议研究的特定焦点是慢性大麻使用对脑后，前额叶皮层和海马的区域脑血流的影响。 如果发生了假设的影响，他们将提供证据表明慢性大麻使用会改变大脑的功能，并且通常在青春期发生的明显大脑发育会增加这种改变的脆弱性。 在不涉及神经影像学的会议上，还将进行其他更广泛的认知测试，以检验以下假设：使用大麻使用的认知效应在早期使用初期和使用时间更长的人中也更为明显。 使用标准化考试成绩的记录，将在爱荷华州的所有部位受过教育的儿童可用的标准化考试成绩记录，将受试者组在前智力函数上匹配。 完成后，拟议的研究将对有关慢性大麻使用对人脑功能，大脑结构和认知影响的影响的知识进行重要的补充。