RACIAL DIFFERENCES IN CIRCULATING SEX STEROIDS: MECHANISMS AND EFFECT ON BONE

循环性类固醇的种族差异：机制及其对骨骼的影响

• 批准号: 7721050
• 负责人: Bogdan J Nowicki
• 金额: $ 8.66万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7721050
• 关键词: Accounting; African American; Architecture; Bone Density; Computer Retrieval of Information on Scientific Projects Database; Condition; Endocrine; Female; Funding; Gonadal Steroid Hormones; Grant; Hormones; Institution; Leiomyoma; Life; Malignant Neoplasms; Measures; Medical; Menstrual cycle; Methods; Organ; Osteoporosis; Process; Purpose; Research; Research Personnel; Resources; Source; United States National Institutes of Health; bone; improved; prevent; racial difference

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall hypothesis of this study is that elevated sex steroid levels may account for some of the hormone-related conditions that follow throughout life in African-American females, including leiomyomas, endocrine related cancers, and protection from osteoporosis. If so, it may begin to be understood the contribution to these processes, both protective and additive, in Black females, and also will allow differences in sex steroid levels in the normal menstrual cycle, as well as to identify mechanisms. The study will further propose to examine the effects of sex steroids on an end organ-in this case bone mineral density and architecture. The purpose of this study is to see if levels of female compared to white females. If so, we may begin to understand their contribution to certain illnesses in Black females allowing us to improve methods of preventing medical these illnesses. The study will measure differences in hormone levels in the normal menstrual cycle, as well as determine reasons for these differences.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 这项研究的总体假设是，性类固醇水平升高可能是非洲裔美国女性终生出现的一些与激素相关的疾病的原因，包括平滑肌瘤、内分泌相关癌症和预防骨质疏松症。 如果是这样，人们可能会开始了解黑人女性对这些过程的贡献，包括保护性和附加性，并且也将允许正常月经周期中性类固醇水平的差异，以及确定机制。 该研究将进一步研究性类固醇对终末器官的影响——在本例中是骨矿物质密度和结构。 本研究的目的是了解女性与白人女性的水平是否相同。 如果是这样，我们可能会开始了解它们对黑人女性某些疾病的影响，从而使我们能够改进预防这些疾病的医疗方法。 该研究将测量正常月经周期中激素水平的差异，并确定这些差异的原因。