Cooperative Center for Research in Reproduction

生殖研究合作中心

• 批准号: 7286628
• 负责人: Bogdan J Nowicki
• 金额: $ 130.84万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-10 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7286628
• 关键词: Address; African American; Androgens; Area; Benign; Bioavailable; Bone Density; Breast; Caucasians; Caucasoid Race; Clinical Research; Collaborations; Condition; Core Facility; Development; Disease; Endocrinology; Endometrial Carcinoma; Exposure to; Female; Foundations; Funding; Goals; Gonadal Steroid Hormones; Growth; Gynecologic; High Prevalence; Hormones; Knowledge; Leiomyoma; Life Style; Malignant Neoplasms; Medical; Mentorship; Metformin; Minority; Morbidity - disease rate; Numbers; Oral Contraceptives; Osteoporosis; Pennsylvania; Personal Satisfaction; Polycystic Ovary Syndrome; Principal Investigator; Race; Reporting; Reproduction; Reproductive Endocrinology; Research; Research Infrastructure; Research Peer Review; Research Personnel; Research Project Grants; Research Proposals; Research Support; Resources; Role; Safety; Science; Score; Solid; Study Subject; Universities; Uterine Fibroids; age difference; base; clinically relevant; college; experience; medical schools; programs; racial difference; reproductive; research and development; sound; tumor

DESCRIPTION (provided by applicant): The collaborative partnership of Pennsylvania State University (PSU) and Meharry Medical College (MMC) proposes the development of a Cooperative Center for Research in Reproduction at MMC. The proposal addresses two goals. First, the Center will conduct scientifically sound, clinically relevant research in a thematically focused area of gynecologic endocrinology. Specifically, the research development core will study: 1) the role of sex steroid hormones as determinants of bone mineral density score in Black females, 2) the influence of oral contraceptives on the growth of uterine fibroids, and 3) the efficacy and safety of metformin and lifestyle factors in the amelioration of hyperandrogenemia and its associated symptomatology. These studies will generate knowledge and comparisons across race. Secondly, the compelling need to strengthen research infrastructure at a historically Black medical school through development of minority-initiated research proposals, collaboration and mentorship with a research intensive institutional network of experienced investigators, toward the eventual capacity to build an independent clinical research team at MMC will be facilitated. Additionally, core research support resources will be enhanced at MMC.

描述（由申请人提供）：宾夕法尼亚州立大学 (PSU) 和梅哈里医学院 (MMC) 的合作伙伴关系提议在 MMC 建立生殖研究合作中心。该提案涉及两个目标。首先，该中心将在妇科内分泌学主题领域开展科学合理、临床相关的研究。具体来说，研究开发核心将研究：1）性类固醇激素作为黑人女性骨矿物质密度评分决定因素的作用，2）口服避孕药对子宫肌瘤生长的影响，以及3）口服避孕药的有效性和安全性二甲双胍和生活方式因素在改善高雄激素血症及其相关症状中的作用。这些研究将产生跨种族的知识和比较。其次，迫切需要通过制定少数族裔发起的研究提案、与经验丰富的研究人员组成的研究密集型机构网络的合作和指导来加强历史悠久的黑人医学院的研究基础设施，以最终有能力在 MMC 建立独立的临床研究团队将得到便利。此外，MMC 的核心研究支持资源也将得到加强。