ADMINISTRATIVE CORE

行政核心

• 批准号: 7720615
• 负责人: EVE J. HIGGINBOTHAM
• 金额: $ 37.08万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7720615
• 关键词: Affect; African American; Alabama; Americas; Area; Award; Awareness; Basic Science; Benchmarking; Bioinformatics; Biological; Biometry; Blood; Blood Vessels; Boston; Cardiology; Cardiovascular system; Centers for Disease Control and Prevention (U.S.); Church; Clinical; Clinical Research; Clinical Trials; Collaborations; Communities; Community Health; Community Health Education; Community Networks; Community Outreach; Community Practice; Computer Retrieval of Information on Scientific Projects Database; Consultations; Core Facility; County; Critical Care; Data; Data Coordinating Center; Development; Discipline of Nursing; Education; Educational Curriculum; Enrollment; Event; Extramural Activities; Faculty; Family Practice; Foundations; Funding; Gerontology; Gifts; Goals; Government; Grant; Growth; Health; Health Services Research; Healthcare; Heart failure; Hypertension; Industry; Informatics; Institutes; Institution; Interdisciplinary Study; Internal Medicine; Intervention Studies; Laboratories; Link; Manuscripts; Master of Science; Medical; Mentors; Methods; Minority; Mission; Modeling; Myocardial Ischemia; Myocardium; National Center for Research Resources; Numbers; Nurses; Nursing Faculty; Occupations; Operative Surgical Procedures; Participant; Patient Care; Patients; Pediatrics; Physicians; Play; Population; Prevention intervention; Preventive Medicine; Process; Process Assessment; Productivity; Program Development; Protocols documentation; Publications; Publishing; Radio; Recording of previous events; Recruitment Activity; Registries; Request for Applications; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Role; Sampling; Scientist; Screening procedure; Secure; Source; Specimen; Standards of Weights and Measures; Stroke prevention; Structure; Support of Research; Training; Training Programs; USA Georgia; Ultrasonography; Underrepresented Minority; Underserved Population; United States National Aeronautics and Space Administration; United States National Institutes of Health; United States Public Health Service; Universities; Urine; Virginia; Western Asia Georgia; anticancer research; base; career; clinical research site; data management; effectiveness research; experience; genetic epidemiology; health disparity; improved; medical schools; minority health; practical application; programs; research study; success; Affect; African American; Alabama; Americas; Area; Award; Awareness; Basic Science; Benchmarking; Bioinformatics; Biological; Biometry; Blood; Blood Vessels; Boston; Cardiology; Cardiovascular system; Centers for Disease Control and Prevention (U.S.); Church; Clinical; Clinical Research; Clinical Trials; Collaborations; Communities; Community Health; Community Health Education; Community Networks; Community Outreach; Community Practice; Computer Retrieval of Information on Scientific Projects Database; Consultations; Core Facility; County; Critical Care; Data; Data Coordinating Center; Development; Discipline of Nursing; Education; Educational Curriculum; Enrollment; Event; Extramural Activities; Faculty; Family Practice; Foundations; Funding; Gerontology; Gifts; Goals; Government; Grant; Growth; Health; Health Services Research; Healthcare; Heart failure; Hypertension; Industry; Informatics; Institutes; Institution; Interdisciplinary Study; Internal Medicine; Intervention Studies; Laboratories; Link; Manuscripts; Master of Science; Medical; Mentors; Methods; Minority; Mission; Modeling; Myocardial Ischemia; Myocardium; National Center for Research Resources; Numbers; Nurses; Nursing Faculty; Occupations; Operative Surgical Procedures; Participant; Patient Care; Patients; Pediatrics; Physicians; Play; Population; Prevention intervention; Preventive Medicine; Process; Process Assessment; Productivity; Program Development; Protocols documentation; Publications; Publishing; Radio; Recording of previous events; Recruitment Activity; Registries; Request for Applications; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Role; Sampling; Scientist; Screening procedure; Secure; Source; Specimen; Standards of Weights and Measures; Stroke prevention; Structure; Support of Research; Training; Training Programs; USA Georgia; Ultrasonography; Underrepresented Minority; Underserved Population; United States National Aeronautics and Space Administration; United States National Institutes of Health; United States Public Health Service; Universities; Urine; Virginia; Western Asia Georgia; anticancer research; base; career; clinical research site; data management; effectiveness research; experience; genetic epidemiology; health disparity; improved; medical schools; minority health; practical application; programs; research study; success

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Continued support is requested for the Clinical Research Center(CRC) through the Research Center for Minority Institutions (RCMI) Clinical Research Infrastructure Initiative. The CRC at the Morehouse School of Medicine (MSM) was the first major step in embarking the institution on fulfilling its mission of improving the health of the underserved minority population in the area of patient care. As a young institution, MSM recognizes the long history that clinical research centers have played in improving the standards of health care in America as well as globally. The presence of the CRC at MSM has had great influence upon the faculty to focus research on those health problems that disproportionately affect minorities and underserved populations of the U.S. This has led to greater collaboration between the basic science faculty and the clinical faculty in research endeavors. It has further led to collaborations for training and/or research of clinical faculty with Harvard University School of Medicine, Centers for Disease Control (CDC), Emory University, Georgia State University, Boston University, University of Alabama and Fulton County Department of Health and Wellness. During the last four years of the RCMI, support for the CRC clinical research activities at MSM has increased from 4 to 27 Public Health Service (PHS) - funded clinical research - oriented studies (67% increase), with a number under review. Research projects supported through the CRC increased from zero during 1995-96 academic year to 12 in 1998-99. Continued support is requested to aid MSM in continuation of its effort to build a research program in clinical research to make it competitive for research support from government and private foundations. In this application, we are requesting continued support of the Administrative and Clinical Core, with additional support for the Informatics, and Recruitment Core. This will enhance our ability to support and coordinate clinical studies at multiple clinical sites. This will also allow the CRC to coordinate extramural studies at multiple clinical sites. Progress 2002 The Clinical Research Center at Morehouse School of Medicine has continued on a trajectory of research productivity and growth: 1. traditional benchmarks of research productivity 2. expansion and increased utilization of the centers core facilities (analytical, biostatistics, nursing/recruitment, ultrasound) 3. internal multidisciplinary collaborations 4. community partnerships 5. external collaborations 6. clinical research education curriculum development Research Productivity: CRC investigators published 35 manuscripts in the current grant cycle, compared with 22 from the previous cycle; 31 new grants were funded, compared with 16 from the previous year of the 47 active protocols in the center; 80% are investigator- initiated, and 70% are funded by the NIH. Multidisciplinary Collaborations: CRC investigators in collaboration with other MSM departments, centers and institutes launched three major initiatives: The EXPORT program is funded by the National Center for Minority Health The Stroke Prevention Intervention Research Program (SPIRP) is jointly- funded by the NINDS, NCRR and NHCB The BioInformatics Infrastructure Initiative was jointly developed by the RCMI, RCII (CRC) programs, in collaboration with basic science departments and centers. Community Partnerships (CPN) A Community Practice Network has been established to expand the clinical research patient and investigator base of the CRC. This program recently received additional funding from the Medtronic Foundation. A continuing success story is the Community Advisory Board, to promote awareness of the benefits of clinical research, and to increase the recruitment of African American patients into MSM research studies. Clinical Research Education and Curriculum Development (CRECD) This program will enter its second year of a projected five- year funding cycle in September 2003. Nine junior faculty from five clinical departments (Internal Medicine, Community Health and Preventive Medicine, Family Medicine and Pediatrics) are pursuing rigorous didactic coursework and mentored research projects in the following areas: External Collaborations (grants or program area) Emory University (Reynold's Foundation application) University of Alabama Birmingham (Cancer Research; CRECD) Duke University (Community Practice Network; CRECD) Boston University (SCOR in ischemic heart disease) University of Virginia Charlottesville (CCRE program) St. Louis University (CCRE program) Progress 2003-2004 The Clinical Research Center (CRC) has three primary objectives: The following summarizes major functions and accomplishments in the current year. 1. Provide an infrastructure necessary to conduct quality clinical research. 2. Increase the number and quality of clinicians actively engaged in clinical research through focused training and faculty development programs. 3. Encourage and facilitate research collaborations between basic scientists and clinicians. The CRC has been very productive in traditional benchmarks such as publications and grants. Annual research productvity includes submission of 15 manuscripts and grants. . The Biostatistical and Data Management Core (BDMC) serves as a shared MSM resource in support of internal and external research collaborations. These core activities assure scientific merit and quality of research projects and are critically important to the overall productivity of any research program. For 2003, this unit provided expert consultation to 32 investigators here on the MSM campus and 13 extramurally. The Cardiovascular Ultrasound-Imaging Core (CUIC) serves as a key component of the needed cardiovascular research infrastructure in evaluating the mechanisms of heart muscle and blood vessels changes in hypertension and its complications. The Ultrasound Imaging Core supports 10 major resource projects funded by various agencies, including NASA and NIH. The Recruitment Core has expanded its role to the community to include a Community Advisory Board, and a weekly radio broadcast. In addition to helping to recruit participants into clinical research, the unit also provides considerable community education through multiple health screening events in local churches, job fairs and malls. The University of Alabama at Birmingham is collaborating with the CRC on this core. In year 2003, this team was able to screen 1873 potential participants, with 612 actually enrolled into various MSM/CRC trials. The Analytical Laboratory provides analytical assistance to MSM investigators by developing/modifying and standardizing methods essential to their respective research projects. Over the past year, this lab has processed 611 samples for investigators such as Drs. Bradford, I. Abukhalaf, M. Bayorh, J. Menter, L. Penix, W. Royal, J. Hibbert, and E. Ofili. The Nursing/Coordinator Core support is provided by a staff of highly motivated, skilled professionals who possess diverse experience in such areas as Critical Care, Cardiology, Gerontology, and Medical-Surgical. They collect research data, perform focused research, and patient care assessments, and process blood, urine and other biological specimens. In conjunction with the Administrative Director, this core supports 20 NIH and industry supported research studies. The Master of Science in Clinical Research is in its second year and central to our efforts to increase the number and quality of clinical researchers at MSM. It is accredited and fully integrated into the GEBS program. Collaborations with the University of Alabama Birmingham; Duke University; NIH and University of Rochester are important accomplishments this year. The first four fellows will graduate in May 2004 and are expected to win additional research awards to continue their career development The Clinical Research Center of Excellence (CCRE) Award (October 1999) to Morehouse School of Medicine has allowed considerable expansion of the infrastructure of the Clinical Research Center through the establishment of several core facilities or programs: Genetic Epidemiology Program, Ultrasound Core Laboratory. The CCRE provides a milieu for the mentoring of junior investigators. The Community Practice Network (CPN) is a first of its kind, and promises to revolutionize clinical research practice and application in the African-American community. The CRC received pilot funding from the Health Disparities Center Initiative (National Center for Minority Health). The Medtronic Foundation has given a $1 million gift to help the Community Practice Network establish clinical practice Registries to support patient, physician education and clinical trials. In year 1 and 2, we will focus on the hypertension and heart failure registry. A major goal of the NIH is for the Clinical Research Center at Morehouse School of Medicine and other RCMI institutions to develop sufficient capacity with NIH funded investigators and projects in order to compete for a GCRC award (General Clinical Research Center). It is important to recognize that the Morehouse School Of Medicine Clinical Research Center has grown into a broad umbrella organization that supports activities beyond what typical General Clinical Research Centers support. In addition to the biostatistics, analytical laboratory and nursing support of traditional General Clinical Research Centers, Morehouse School of Medicine Clinical Research Center also has an accredited clinical research training program, a health services research component through the Program of Healthcare Effectiveness Research, community outreach through the Community Practice Network and the participant recruitment core. Such an umbrella structure allows the Clinical Research Centers to integrate resources across its various units, and leverage existing resources to attract new funds for the center. The Center of Clinical Research Excellence (CCRE) is one such unit that has significantly increased research capacity at the CRC. In the CCRE model, established investigators interact with junior investigators, using Clinical Research Center and CCRE core laboratory support. The CCRE model has been critical to the success of the recently- established Master of Science in Clinical Research Program. The Clinical Research Center program priorities for FY 2004 and 2005 were to: 1. Expand and institutionalize the Community Practice Network (CPN) as a resource for physicians and participant education and recruitment for Morehouse School Of Medicine sponsored clinical trials. 2. Develop a clinical research informatics network for support of the Community Practice Network. 3. Establish the Biostatistical core as a Data Coordinating Center that will serve multi-center and multi-institutional protocols. 4. Secure renewal funds for the CCRE (4/04) and CRC (4/05). 5. Expand the Clinical Research Center investigator and project base. 6. Seek additional funds to support and expand the Masters of Science in Clinical Research (MSCR) Program. 7. Expand the CRC recruitment core, with appropriate links to the Office of Public Affairs and other Morehouse School of Medicine community resources.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 通过少数民族机构研究中心（RCMI）临床研究基础设施倡议，请求继续支持临床研究中心（CRC）。 Morehouse医学院（MSM）的CRC是踏上该机构履行其在患者护理领域改善未服务不足少数群体健康的使命的第一步。 作为一个年轻的机构，MSM认识到临床研究中心在改善美国和全球医疗保健标准方面发挥的悠久历史。 CRC在MSM的存在对教职员工的影响很大，将研究重点关注那些对美国少数民族和服务不足的人群的不成比例的健康问题，这导致了基础科学教师与研究工作中的临床教师之间的更大合作。 它进一步导致了与哈佛大学医学院，疾病控制中心（CDC），埃默里大学，佐治亚州立大学，波士顿大学，阿拉巴马大学和富尔顿县健康与健康系进行培训和/或研究的合作。 在RCMI的最后四年中，对MSM的CRC临床研究活动的支持已从4个增加到27个公共卫生服务（PHS） - 资助的临床研究 - 面向临床研究（增加了67％），并正在审查中。通过CRC支持的研究项目从1995-96学年的零增加到1998 - 99年的12个。 请求继续支持以帮助MSM继续努力在临床研究中构建研究计划，以使其在政府和私人基金会的研究支持方面具有竞争力。 在此应用程序中，我们要求持续支持行政和临床核心，并为信息学和招聘核心提供额外的支持。 这将增强我们在多个临床部位支持和协调临床研究的能力。 这也将使CRC能够在多个临床部位协调壁外研究。 进度2002 莫尔豪斯医学院的临床研究中心继续研究了研究生产力和增长的轨迹： 1。研究生产力的传统基准 2。核心设施的扩展和增加利用 （分析，生物统计学，护理/招聘，超声） 3。内部多学科合作 4。社区伙伴关系 5。外部协作 6。临床研究教育课程开发 研究生产率：CRC研究人员在当前赠款周期中发表了35份手稿，而上一个周期中的22个手稿；资助了31个新的赠款，而该中心47个主动方案的前一年为16个；研究人员启动了80％，70％由NIH资助。 多学科合作：CRC调查人员与其他MSM部门合作，中心和机构启动了三个主要举措： 出口计划由国家少数民族卫生中心资助 中风预防干预研究计划（SPIRP）由NINDS，NCRR和NHCB共同资助 RCMI，RCII（CRC）计划共同制定了生物信息学基础设施计划，并与基础科学部门和中心合作。 社区伙伴关系（CPN） 已经建立了一个社区实践网络，以扩大CRC的临床研究患者和研究者基础。 该计划最近获得了Medtronic Foundation的额外资金。 一个持续的成功故事是社区顾问委员会，以提高人们对临床研究好处的认识，并将非裔美国人患者招募到MSM研究中。 临床研究教育和课程发展（CRECD） 该计划将在2003年9月进入预计五年筹资周期的第二年。来自五个临床部门（内科，社区健康和预防医学，家庭医学和儿科）的九名初级教师正在攻读严格的教学课程，并在以下领域进行了指导研究： 外部合作（赠款或计划领域） 埃默里大学（雷诺的基础申请） 阿拉巴马大学伯明翰大学（癌症研究； CRECD） 杜克大学（社区实践网络； CRECD） 波士顿大学（缺血性心脏病评分） 弗吉尼亚大学夏洛茨维尔大学（CCRE计划） 圣路易斯大学（CCRE计划） 进度2003-2004 临床研究中心（CRC）有三个主要目标： 以下总结了当年的主要职能和成就。 1。提供进行高质量临床研究所需的基础设施。 2。通过重点培训和教师发展计划，增加积极参与临床研究的临床医生的数量和质量。 3。鼓励和促进基础科学家与临床医生之间的研究合作。 CRC在传统基准（例如出版物和赠款）中非常有生产力。 年度研究产品Vity包括提交15项手稿和赠款。 。 生物统计学和数据管理核心（BDMC）是支持内部和外部研究合作的共享MSM资源。 这些核心活动确保了研究项目的科学优点和质量，并且对任何研究计划的整体生产力至关重要。 在2003年，该单元向MSM校园的32名调查人员提供了专家咨询，在外面咨询了13个。 心血管超声导影核心（CUIC）是评估心脏肌肉机制和血管中高血压及其并发症的变化的所需心血管研究基础设施的关键组成部分。 超声成像核心支持包括NASA和NIH在内的各个机构资助的10个主要资源项目。 招聘核心已将其角色扩展到社区，包括社区咨询委员会和每周广播。除了帮助招募参与者参加临床研究外，该部门还通过当地教会，招聘会和购物中心的多次健康筛查活动提供了相当大的社区教育。伯明翰阿拉巴马大学正在与CRC合作。 在2003年，该团队能够筛选1873年的潜在参与者，实际上有612名参加了各种MSM/CRC试验。 分析实验室通过开发/修改和标准化各自研究项目的方法为MSM研究人员提供分析援助。 在过去的一年中，该实验室为DRS等研究人员处理了611个样本。 Bradford，I。Abukhalaf，M。Bayorh，J。Menter，L。Penix，W。Royal，J。Hibbert和E. Ofili。 护理/协调员核心支持由一位具有积极进取的专业人士的员工提供，他们在重症监护，心脏病学，老年病和医学手术方面拥有多样化的经验。 他们收集研究数据，进行重点研究以及患者护理评估，并处理血液，尿液和其他生物标本。 与行政总监一起，该核心支持20名NIH和行业支持研究。 临床研究科学硕士是第二年，这是我们为增加MSM临床研究人员的数量和质量而努力的核心。它被认可并完全集成到GEBS计划中。与阿拉巴马大学伯明翰大学合作；杜克大学； NIH和罗切斯特大学今年是重要的成就。前四个研究员将于2004年5月毕业，预计将赢得额外的研究奖，以继续其职业发展 通过建立多个核心设施或计划的临床研究中心临床研究中心（CCRE）奖（CCRE）奖（1999年10月）允许临床研究中心的基础设施大大扩展：超声核心实验室的遗传流行病学计划。 CCRE为初级调查人员提供了一个环境。 社区实践网络（CPN）是同类产品中的第一个，并有望彻底改变非裔美国人社区的临床研究实践和应用。 CRC从健康差异中心倡议（国家少数民族健康中心）获得了试点资金。 Medtronic Foundation提供了100万美元的礼物，以帮助社区实践网络建立临床实践注册表，以支持患者，医师教育和临床试验。在第1年和第2年，我们将重点关注高血压和心力衰竭注册表。 NIH的主要目标是Morehouse医学院和其他RCMI机构的临床研究中心，以与NIH资助的研究人员和项目一起发展足够的能力，以竞争GCRC奖（一般临床研究中心）。 重要的是要认识到，莫尔豪斯医学院临床研究中心已经发展成为一个庞大的伞组织，该组织支持超出典型的一般临床研究中心支持的活动。 除了传统一般临床研究中心的生物统计学，分析实验室和护理支持外，Morehouse医学学院临床研究中心还具有经过认可的临床研究培训计划，这是通过医疗保健有效性研究计划，通过社区实践网络和参与者招聘核心核心的卫生服务研究组成部分。 这样的雨伞结构使临床研究中心可以整合其各个单位的资源，并利用现有资源来吸引该中心的新资金。 卓越临床研究中心（CCRE）就是这样一个单位，该单元在CRC的研究能力大大提高了。 在CCRE模型中，建立的研究人员使用临床研究中心和CCRE核心实验室支持与初级研究人员进行互动。 CCRE模型对于最近建立的临床研究计划的成功至关重要。 2004财年和2005财年的临床研究中心计划的优先事项是： 1。扩大和制度化社区实践网络（CPN），作为医师和参与者教育和招聘的资源，用于莫尔豪斯医学院赞助的临床试验。 2。开发一个临床研究信息学网络，以支持社区实践网络。 3。建立生物统计核心作为数据协调中心，该中心将服务于多中心和多机构方案。 4。为CCRE（4/04）和CRC（4/05）获得续订资金。 5。扩展临床研究中心研究者和项目基础。 6.寻求额外的资金来支持和扩大临床研究硕士学位（MSCR）计划。 7.扩大CRC招聘核心，并与公共事务办公室和其他Morehouse医学院社区资源有适当的联系。