ADMINISTRATIVE CORE

行政核心

• 批准号: 7960766
• 负责人: EVE J. HIGGINBOTHAM
• 金额: $ 6.18万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7960766
• 关键词: Affect; African American; Alabama; Americas; Area; Award; Awareness; Basic Science; Benchmarking; Bioinformatics; Biological; Biometry; Blood; Blood Vessels; Boston; Cardiology; Cardiovascular system; Centers for Disease Control and Prevention (U.S.); Church; Clinical; Clinical Research; Clinical Trials; Collaborations; Communities; Community Health; Community Health Education; Community Networks; Community Outreach; Community Practice; Computer Retrieval of Information on Scientific Projects Database; Consultations; Core Facility; County; Critical Care; Data; Data Coordinating Center; Development; Discipline of Nursing; Education; Educational Curriculum; Enrollment; Event; Extramural Activities; Faculty; Family Practice; Foundations; Funding; Gerontology; Gifts; Goals; Government; Grant; Growth; Health; Health Services Research; Healthcare; Heart failure; Hypertension; Industry; Informatics; Institutes; Institution; Interdisciplinary Study; Internal Medicine; Intervention Studies; Laboratories; Link; Manuscripts; Master of Science; Medical; Mentors; Methods; Minority; Mission; Modeling; Myocardial Ischemia; Myocardium; National Center for Research Resources; National Institute of Neurological Disorders and Stroke; Nurses; Nursing Faculty; Occupations; Operative Surgical Procedures; Participant; Patient Care; Patients; Pediatrics; Physicians; Play; Population; Preventive Intervention; Preventive Medicine; Process; Process Assessment; Productivity; Program Development; Protocols documentation; Publications; Publishing; Radio; Recording of previous events; Recruitment Activity; Registries; Request for Applications; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Role; Sampling; Scientist; Screening procedure; Secure; Source; Specimen; Stroke prevention; Structure; Training; Training Programs; Ultrasonography; Underrepresented Minority; Underserved Population; United States National Aeronautics and Space Administration; United States National Institutes of Health; United States Public Health Service; Universities; Urine; Virginia; anticancer research; base; career development; clinical practice; clinical research site; data management; effectiveness research; experience; genetic epidemiology; health disparity; improved; medical schools; minority health; practical application; programs; research study; success

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Continued support is requested for the Clinical Research Center(CRC) through the Research Center for Minority Institutions (RCMI) Clinical Research Infrastructure Initiative. The CRC at the Morehouse School of Medicine (MSM) was the first major step in embarking the institution on fulfilling its mission of improving the health of the underserved minority population in the area of patient care. As a young institution, MSM recognizes the long history that clinical research centers have played in improving the standards of health care in America as well as globally. The presence of the CRC at MSM has had great influence upon the faculty to focus research on those health problems that disproportionately affect minorities and underserved populations of the U.S. This has led to greater collaboration between the basic science faculty and the clinical faculty in research endeavors. It has further led to collaborations for training and/or research of clinical faculty with Harvard University School of Medicine, Centers for Disease Control (CDC), Emory University, Georgia State University, Boston University, University of Alabama and Fulton County Department of Health and Wellness. During the last four years of the RCMI, support for the CRC clinical research activities at MSM has increased from 4 to 27 Public Health Service (PHS) - funded clinical research - oriented studies (67% increase), with a number under review. Research projects supported through the CRC increased from zero during 1995-96 academic year to 12 in 1998-99. Continued support is requested to aid MSM in continuation of its effort to build a research program in clinical research to make it competitive for research support from government and private foundations. In this application, we are requesting continued support of the Administrative and Clinical Core, with additional support for the Informatics, and Recruitment Core. This will enhance our ability to support and coordinate clinical studies at multiple clinical sites. This will also allow the CRC to coordinate extramural studies at multiple clinical sites. Progress 2002 The Clinical Research Center at Morehouse School of Medicine has continued on a trajectory of research productivity and growth: 1. traditional benchmarks of research productivity 2. expansion and increased utilization of the centers core facilities (analytical, biostatistics, nursing/recruitment, ultrasound) 3. internal multidisciplinary collaborations 4. community partnerships 5. external collaborations 6. clinical research education curriculum development Research Productivity: CRC investigators published 35 manuscripts in the current grant cycle, compared with 22 from the previous cycle; 31 new grants were funded, compared with 16 from the previous year of the 47 active protocols in the center; 80% are investigator- initiated, and 70% are funded by the NIH. Multidisciplinary Collaborations: CRC investigators in collaboration with other MSM departments, centers and institutes launched three major initiatives: The EXPORT program is funded by the National Center for Minority Health The Stroke Prevention Intervention Research Program (SPIRP) is jointly- funded by the NINDS, NCRR and NHCB The BioInformatics Infrastructure Initiative was jointly developed by the RCMI, RCII (CRC) programs, in collaboration with basic science departments and centers. Community Partnerships (CPN) A Community Practice Network has been established to expand the clinical research patient and investigator base of the CRC. This program recently received additional funding from the Medtronic Foundation. A continuing success story is the Community Advisory Board, to promote awareness of the benefits of clinical research, and to increase the recruitment of African American patients into MSM research studies. Clinical Research Education and Curriculum Development (CRECD) This program will enter its second year of a projected five- year funding cycle in September 2003. Nine junior faculty from five clinical departments (Internal Medicine, Community Health and Preventive Medicine, Family Medicine and Pediatrics) are pursuing rigorous didactic coursework and mentored research projects in the following areas: External Collaborations (grants or program area) Emory University (Reynold's Foundation application) University of Alabama Birmingham (Cancer Research; CRECD) Duke University (Community Practice Network; CRECD) Boston University (SCOR in ischemic heart disease) University of Virginia Charlottesville (CCRE program) St. Louis University (CCRE program) Progress 2003-2004 The Clinical Research Center (CRC) has three primary objectives: The following summarizes major functions and accomplishments in the current year. 1. Provide an infrastructure necessary to conduct quality clinical research. 2. Increase the number and quality of clinicians actively engaged in clinical research through focused training and faculty development programs. 3. Encourage and facilitate research collaborations between basic scientists and clinicians. The CRC has been very productive in traditional benchmarks such as publications and grants. Annual research productvity includes submission of 15 manuscripts and grants. . The Biostatistical and Data Management Core (BDMC) serves as a shared MSM resource in support of internal and external research collaborations. These core activities assure scientific merit and quality of research projects and are critically important to the overall productivity of any research program. For 2003, this unit provided expert consultation to 32 investigators here on the MSM campus and 13 extramurally. The Cardiovascular Ultrasound-Imaging Core (CUIC) serves as a key component of the needed cardiovascular research infrastructure in evaluating the mechanisms of heart muscle and blood vessels changes in hypertension and its complications. The Ultrasound Imaging Core supports 10 major resource projects funded by various agencies, including NASA and NIH. The Recruitment Core has expanded its role to the community to include a Community Advisory Board, and a weekly radio broadcast. In addition to helping to recruit participants into clinical research, the unit also provides considerable community education through multiple health screening events in local churches, job fairs and malls. The University of Alabama at Birmingham is collaborating with the CRC on this core. In year 2003, this team was able to screen 1873 potential participants, with 612 actually enrolled into various MSM/CRC trials. The Analytical Laboratory provides analytical assistance to MSM investigators by developing/modifying and standardizing methods essential to their respective research projects. Over the past year, this lab has processed 611 samples for investigators such as Drs. Bradford, I. Abukhalaf, M. Bayorh, J. Menter, L. Penix, W. Royal, J. Hibbert, and E. Ofili. The Nursing/Coordinator Core support is provided by a staff of highly motivated, skilled professionals who possess diverse experience in such areas as Critical Care, Cardiology, Gerontology, and Medical-Surgical. They collect research data, perform focused research, and patient care assessments, and process blood, urine and other biological specimens. In conjunction with the Administrative Director, this core supports 20 NIH and industry supported research studies. The Master of Science in Clinical Research is in its second year and central to our efforts to increase the number and quality of clinical researchers at MSM. It is accredited and fully integrated into the GEBS program. Collaborations with the University of Alabama Birmingham; Duke University; NIH and University of Rochester are important accomplishments this year. The first four fellows will graduate in May 2004 and are expected to win additional research awards to continue their career development The Clinical Research Center of Excellence (CCRE) Award (October 1999) to Morehouse School of Medicine has allowed considerable expansion of the infrastructure of the Clinical Research Center through the establishment of several core facilities or programs: Genetic Epidemiology Program, Ultrasound Core Laboratory. The CCRE provides a milieu for the mentoring of junior investigators. The Community Practice Network (CPN) is a first of its kind, and promises to revolutionize clinical research practice and application in the African-American community. The CRC received pilot funding from the Health Disparities Center Initiative (National Center for Minority Health). The Medtronic Foundation has given a $1 million gift to help the Community Practice Network establish clinical practice Registries to support patient, physician education and clinical trials. In year 1 and 2, we will focus on the hypertension and heart failure registry. A major goal of the NIH is for the Clinical Research Center at Morehouse School of Medicine and other RCMI institutions to develop sufficient capacity with NIH funded investigators and projects in order to compete for a GCRC award (General Clinical Research Center). It is important to recognize that the Morehouse School Of Medicine Clinical Research Center has grown into a broad umbrella organization that supports activities beyond what typical General Clinical Research Centers support. In addition to the biostatistics, analytical laboratory and nursing support of traditional General Clinical Research Centers, Morehouse School of Medicine Clinical Research Center also has an accredited clinical research training program, a health services research component through the Program of Healthcare Effectiveness Research, community outreach through the Community Practice Network and the participant recruitment core. Such an umbrella structure allows the Clinical Research Centers to integrate resources across its various units, and leverage existing resources to attract new funds for the center. The Center of Clinical Research Excellence (CCRE) is one such unit that has significantly increased research capacity at the CRC. In the CCRE model, established investigators interact with junior investigators, using Clinical Research Center and CCRE core laboratory support. The CCRE model has been critical to the success of the recently- established Master of Science in Clinical Research Program. The Clinical Research Center program priorities for FY 2004 and 2005 were to: 1. Expand and institutionalize the Community Practice Network (CPN) as a resource for physicians and participant education and recruitment for Morehouse School Of Medicine sponsored clinical trials. 2. Develop a clinical research informatics network for support of the Community Practice Network. 3. Establish the Biostatistical core as a Data Coordinating Center that will serve multi-center and multi-institutional protocols. 4. Secure renewal funds for the CCRE (4/04) and CRC (4/05). 5. Expand the Clinical Research Center investigator and project base. 6. Seek additional funds to support and expand the Masters of Science in Clinical Research (MSCR) Program. 7. Expand the CRC recruitment core, with appropriate links to the Office of Public Affairs and other Morehouse School of Medicine community resources.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 请求通过少数民族机构研究中心 (RCMI) 临床研究基础设施计划继续为临床研究中心 (CRC) 提供支持。 莫尔豪斯医学院 (MSM) 的 CRC 是该机构履行其使命的第一个重要步骤，即改善患者护理领域服务不足的少数群体的健康状况。 作为一个年轻的机构，MSM 认识到临床研究中心在提高美国乃至全球医疗保健标准方面所发挥的悠久历史。 CRC 在 MSM 的存在对教师们产生了巨大的影响，使他们能够将研究重点放在那些对美国少数族裔和服务水平低下的人群造成不成比例影响的健康问题上。这使得基础科学教师和临床教师在研究工作中加强了合作。 它还进一步促成了与哈佛大学医学院、疾病控制中心 (CDC)、埃默里大学、佐治亚州立大学、波士顿大学、阿拉巴马大学和富尔顿县卫生局的临床教师培训和/或研究合作。健康。 在 RCMI 的过去四年中，MSM 对 CRC 临床研究活动的支持已从 4 项增加到 27 项公共卫生服务 (PHS) 资助的临床研究导向的研究（增加了 67%），其中一些正在审查中。 CRC支持的研究项目从1995-96学年的零增加到1998-99学年的12个。 请求继续提供支持，帮助 MSM 继续努力建立临床研究项目，使其在政府和私人基金会的研究支持方面具有竞争力。 在此申请中，我们请求行政和临床核心的持续支持，以及信息学和招聘核心的额外支持。 这将增强我们支持和协调多个临床中心临床研究的能力。 这也将使 CRC 能够协调多个临床中心的校外研究。 2002年进步 莫尔豪斯医学院临床研究中心继续沿着研究生产力和增长的轨道前进： 1. 研究生产力的传统基准 2. 扩大中心核心设施并提高其利用率 （分析、生物统计学、护理/招聘、超声） 3. 内部多学科合作 4. 社区伙伴关系 5. 外部合作 6. 临床研究教育课程开发 研究生产力：CRC 研究人员在当前资助周期中发表了 35 篇手稿，而上一周期为 22 篇；获得了 31 项新赠款，而去年该中心的 47 项现行协议中只有 16 项； 80% 由研究者发起，70% 由 NIH 资助。 多学科合作：CRC 研究人员与其他 MSM 部门、中心和研究所合作发起了三项主要举措： EXPORT 计划由国家少数民族健康中心资助 中风预防干预研究计划 (SPIRP) 由 NINDS、NCRR 和 NHCB 联合资助 生物信息学基础设施计划由 RCMI、RCII (CRC) 项目与基础科学部门和中心合作共同制定。 社区伙伴关系 (CPN) 已经建立了社区实践网络，以扩大 CRC 的临床研究患者和研究者基础。 该计划最近获得了美敦力基金会的额外资助。 社区咨询委员会是一个持续成功的案例，旨在提高人们对临床研究益处的认识，并增加招募非裔美国患者参与 MSM 研究。 临床研究教育和课程开发（CRECD） 该计划将于 2003 年 9 月进入预计五年资助周期的第二年。来自五个临床科室（内科、社区健康和预防医学、家庭医学和儿科）的 9 名初级教员正在从事严格的教学课程和指导研究项目在以下领域： 外部合作（赠款或计划领域） 埃默里大学（雷诺基金会申请） 阿拉巴马大学伯明翰分校（癌症研究；CRECD） 杜克大学（社区实践网络；CRECD） 波士顿大学（缺血性心脏病 SCOR） 弗吉尼亚大学夏洛茨维尔分校（CCRE 项目） 圣路易斯大学（CCRE 项目） 2003-2004 年进展 临床研究中心 (CRC) 具有三个主要目标： 现将今年以来的主要工作和取得的成绩总结如下。 1. 提供进行高质量临床研究所需的基础设施。 2. 通过重点培训和师资发展计划，提高积极从事临床研究的临床医生的数量和质量。 3. 鼓励和促进基础科学家和临床医生之间的研究合作。 CRC 在出版物和赠款等传统基准方面非常富有成效。 年度研究成果包括提交 15 份手稿和资助。 。 生物统计和数据管理核心 (BDMC) 作为共享 MSM 资源，支持内部和外部研究合作。 这些核心活动确保了研究项目的科学价值和质量，并且对于任何研究项目的整体生产力都至关重要。 2003 年，该部门为 MSM 校园内的 32 名研究人员和校外的 13 名研究人员提供了专家咨询。 心血管超声成像核心 (CUIC) 是评估高血压及其并发症中心肌和血管变化机制所需的心血管研究基础设施的关键组成部分。 超声成像核心支持由 NASA 和 NIH 等多个机构资助的 10 个主要资源项目。 招聘核心已将其作用扩展到社区，包括社区咨询委员会和每周广播。除了帮助招募参与者参与临床研究外，该部门还通过在当地教堂、招聘会和商场举办的多次健康检查活动提供大量的社区教育。阿拉巴马大学伯明翰分校正在与 CRC 就这一核心项目进行合作。 2003 年，该团队筛选了 1873 名潜在参与者，其中 612 名实际参加了各种 MSM/CRC 试验。 分析实验室通过开发/修改和标准化各自研究项目所必需的方法，为 MSM 研究人员提供分析帮助。 在过去的一年里，该实验室已为 Drs. 等研究人员处理了 611 个样本。布拉德福德、I. Abukhalaf、M. Bayorh、J. Menter、L. Penix、W. Royal、J. Hibbert 和 E. Ofili。 护理/协调员核心支持由一群积极主动、技术精湛的专业人员提供，他们在重症监护、心脏病学、老年学和内外科等领域拥有丰富的经验。 他们收集研究数据，进行重点研究和患者护理评估，并处理血液、尿液和其他生物样本。 该核心与行政主任一起支持 20 项 NIH 和行业支持的研究。 临床研究理学硕士项目已进入第二年，它是我们努力提高 MSM 临床研究人员数量和质量的核心。它已获得认可并完全融入 GEBS 计划。与阿拉巴马大学伯明翰分校合作；杜克大学；美国国立卫生研究院和罗切斯特大学今年取得了重要成就。前四名研究员将于 2004 年 5 月毕业，预计将获得额外的研究奖项以继续他们的职业发展 莫尔豪斯医学院荣获卓越临床研究中心 (CCRE) 奖（1999 年 10 月），通过建立几个核心设施或项目，大幅扩展了临床研究中心的基础设施：遗传流行病学项目、超声核心实验室。 CCRE 为初级研究人员的指导提供了一个环境。 社区实践网络 (CPN) 是此类网络中的首创，有望彻底改变非裔美国人社区的临床研究实践和应用。 CRC 获得了健康差异中心倡议（国家少数民族健康中心）的试点资金。美敦力基金会捐赠了 100 万美元，帮助社区实践网络建立临床实践注册中心，以支持患者、医生教育和临床试验。在第一年和第二年，我们将重点关注高血压和心力衰竭登记。 NIH 的一个主要目标是让莫尔豪斯医学院的临床研究中心和其他 RCMI 机构与 NIH 资助的研究人员和项目一起发展足够的能力，以便竞争 GCRC 奖（普通临床研究中心）。 重要的是要认识到莫尔豪斯医学院临床研究中心已经发展成为一个广泛的伞式组织，支持的活动超出了典型的普通临床研究中心支持的范围。 除了传统的普通临床研究中心的生物统计、分析实验室和护理支持外，莫尔豪斯医学院临床研究中心还拥有经过认可的临床研究培训计划、通过医疗保健有效性研究计划的健康服务研究部分、通过社区实践网络和参与者招募核心。 这种伞式结构使临床研究中心能够整合各个部门的资源，并利用现有资源为中心吸引新的资金。 临床研究卓越中心 (CCRE) 就是这样一个单位，它显着提高了 CRC 的研究能力。 在 CCRE 模式中，成熟的研究者利用临床研究中心和 CCRE 核心实验室的支持与初级研究者进行互动。 CCRE 模型对于最近设立的临床研究理学硕士项目的成功至关重要。 临床研究中心 2004 和 2005 财年的计划重点是： 1. 扩大社区实践网络 (CPN) 并将其制度化，作为莫尔豪斯医学院赞助的临床试验的医生和参与者教育和招募资源。 2. 开发临床研究信息学网络以支持社区实践网络。 3. 建立生物统计核心作为数据协调中心，为多中心和多机构协议服务。 4. 确保 CCRE (4/04) 和 CRC (4/05) 的更新资金。 5.扩大临床研究中心研究者和项目基地。 6. 寻求额外资金来支持和扩大临床研究理学硕士 (MSCR) 项目。 7. 扩大 CRC 招聘核心，与公共事务办公室和其他莫尔豪斯医学院社区资源建立适当的联系。