The role of negative reinforcement in drug abuse

负强化在药物滥用中的作用

• 批准号: 10356175
• 负责人: Matthew L Banks
• 金额: $ 19.41万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10356175
• 关键词: Address; Affect; Attenuated; Automobile Driving; Behavior; Behavioral; Behavioral Research; Brain region; Chronic; Clinical; Cocaine; Conflict (Psychology); Data; Development; Diagnosis; Dopamine; Drug Exposure; Drug abuse; Effectiveness; Employment; Environment; Excision; Exploratory/Developmental Grant; Female; Fentanyl; Food; Food Interactions; Foundations; Future; Goals; Impairment; Infusion procedures; Injections; Intravenous; Knowledge; Lead; Literature; Methods; Negative Reinforcements; Negative Reinforcer; Neurotransmitters; Opiate Addiction; Oral Contraceptives; Pathway interactions; Pharmaceutical Preparations; Positive Reinforcer; Probability; Procedures; Process; Psychological reinforcement; Rattus; Research; Research Personnel; Role; Self Administration; Shock; Signal Transduction; Social Interaction; Speed; Stimulus; Substance Use Disorder; System; Techniques; Testing; Thinking; addiction; antagonist; attenuation; cocaine self-administration; cost; designer receptors exclusively activated by designer drugs; drug misuse; drug of abuse; drug reinforcement; high risk; improved; innovation; insight; male; neurotransmission; non-drug; novel; novel therapeutics; opioid exposure; opioid use; opioid withdrawal; pre-clinical; pre-clinical research; prevent; reinforced behavior; reinforcer; response; stimulant exposure; stimulant use disorder; transcription factor; transcriptome sequencing; treatment strategy; unintended pregnancy

Project Summary Behavior is governed by contingencies that relate consequent stimuli to responses in the presence of discrete discriminative stimuli. The progression of abused drug misuse to a substance use disorder is diagnosed, in part, by behavior being misallocated towards the abused drug as the positive reinforcer and away from nondrug alternative positive reinforcers (e.g. social interaction, food, employment). Much of this scientific literature has focused on how chronic drug exposure degrades these positive reinforcing stimuli. In contrast, there are few studies that have examined how chronic drug exposure alters behaviors maintained by negative reinforcers (e.g. driving the speed limit to remove the presentation of a speeding ticket). This R21 CEBRA application proposes preclinical research in female and male rats to determine the effects of extended access fentanyl or cocaine self- administration and subsequent termination on behavior maintained by negative reinforcement. Aim #1 will establish a drug-vs-negative reinforcer choice procedure in male and female rats. Aim #2 will compare effects of extended access drug self-administration and extended access negative reinforcement on drug-vs-negative reinforcer chocie.

项目概要 行为受偶然事件的控制，这些偶然事件将随后的刺激与存在离散情况下的反应联系起来。 歧视性刺激。滥用药物误用发展为药物滥用障碍的部分诊断是， 行为被错误地分配给滥用药物作为积极强化物，远离非药物 其他积极强化物（例如社交互动、食物、就业）。大部分科学文献都 重点关注长期药物暴露如何降低这些积极的强化刺激。相比之下，很少有 研究探讨了长期药物暴露如何改变负强化物（例如， 驾驶限速以消除超速罚单）。此 R21 CEBRA 应用建议 对雌性和雄性大鼠进行临床前研究，以确定长期使用芬太尼或可卡因自我治疗的影响 管理和随后终止由负强化维持的行为。目标#1将 在雄性和雌性大鼠中建立药物与阴性强化物的选择程序。目标 #2 将比较以下效果 扩展获取药物自我管理和扩展获取药物与阴性的负强化 强化物选择。

项目成果

Environmental influence on the preclinical evaluation of substance use disorder therapeutics.

环境对物质使用障碍治疗的临床前评估的影响。

• 发表时间: 2022
• 作者: Banks; Matthew L
• 通讯作者: Matthew L

Effects of environmental and pharmacological manipulations on cocaine-vs-negative reinforcer choice in male and female rats.

环境和药理学操作对雄性和雌性大鼠可卡因与阴性强化剂选择的影响。

• 发表时间: 2023-08
• 影响因子: 3.4
• 作者: Marcus, Madison M;Banks, Matthew L
• 通讯作者: Banks, Matthew L

Adding dopamine to the complexity of sex differences in opioid reinforcement.

将多巴胺添加到阿片类药物强化中性别差异的复杂性中。

• 发表时间: 2021
• 作者: Robinson, Hannah L;Banks, Matthew L
• 通讯作者: Banks, Matthew L