Examining the impact of nonfatal and fatal overdose in social networks on individual overdose risk

检查社交网络中非致命和致命用药过量对个人用药过量风险的影响

• 批准号: 10356050
• 负责人: Alexandria Macmadu
• 金额: $ 2.48万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-01 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10356050
• 关键词: Area; Assessment tool; Behavioral; Centers for Disease Control and Prevention (U.S.); Characteristics; Conflict (Psychology); Country; Data; Drug usage; Ego; Enrollment; Epidemic; Event; Exposure to; Fellowship; Fentanyl; Foundations; Funding; Goals; Grief reaction; Harm Reduction; Health; Individual; Individual National Research Service Award; Intervention; Interview; Investigation; Learning; Longevity; Longitudinal Studies; Mediator of activation protein; Methodology; Methods; Modeling; Motivation; National Institute of Drug Abuse; Network-based; Opioid; Overdose; Overdose reduction; Pathway Analysis; Patient Self-Report; Persons; Pharmaceutical Preparations; Qualitative Methods; Randomized Clinical Trials; Reporting; Research; Research Design; Research Methodology; Rhode Island; Risk; Risk Behaviors; Risk Factors; Sampling Studies; Severities; Social Network; Social support; Structure; Surveys; Survivors; System; Training; Trauma; Work; coping; density; design; drug market; evidence base; illicit opioid; member; novel; opioid epidemic; opioid overdose; opioid use; outreach; overdose death; overdose prevention; overdose risk; parent grant; parent project; pre-doctoral; preventive intervention; primary outcome; programs; prospective; research study; response; risk perception; social; social capital; social determinants; social structure; theories; tool

PROJECT SUMMARY The epidemic of opioid-related overdose is a persistent problem in the US. While several social network characteristics have been found to influence individual overdose risk, the influence of overdose occurring within one’s social network on individual overdose risk has not yet been assessed, and potential mediators or moderators of this effect have not yet been explored. The parent project upon which this Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship to Promote Diversity in Health- Related Research (F31 - Diversity) application builds is a randomized clinical trial that will assess an intervention to reduce overdose risk among persons at risk of opioid-related overdose. The objective of this proposal is to examine the influence of nonfatal and fatal overdose in social networks (reported at baseline) on individuals’ subsequent overdose risk at 6- and 12- months post-baseline. This F31, which is undergirded by Protection Motivation Theory, will augment the existing parent grant by developing and integrating an egocentric network assessment tool into existing assessments in the parent project that occur at baseline; this tool will be used to assess exposure to overdose within one’s social network as well as potential moderators of the effect under study. Semi-structured interviews will also be conducted to probe and explore potential mediators of the effect of nonfatal and fatal overdose in social networks on individual overdose risk, including risk perception, trauma, grief, and disruptions in social support and drug supply. The primary outcome for the proposed project will be the rate of self-reported overdose at 6- and 12- months post-baseline, and the primary analysis will be supplemented with data on nonfatal overdose events occurring within 12 months post-baseline, which will ascertained through a CDC-funded statewide overdose surveillance system. This research will be first to utilize a mixed-methods research design to assess the effect of nonfatal and fatal overdose in social networks on individual overdose risk and explore potential mediators and moderators of the effect under investigation. Those who are at risk of overdose require novel, targeted, and effective overdose prevention interventions to mitigate overdose risk, and the proposed research study is well-poised to inform network-based intervention strategies. If successful, the current study may provide additional evidence to provide survivor-centered harm reduction and treatment outreach to individuals who have overdosed and members of their social network.

项目概要 在美国，与阿片类药物相关的过量用药是一个持续存在的问题，而一些社交网络却存在这种问题。 已发现特征会影响个体用药过量风险，用药过量的影响发生在 一个人的社交网络对个人用药过量风险尚未进行评估，潜在的中介或 这种效应的调节因素尚未被探索。 国家研究服务奖 (NRSA) 个人博士前奖学金，以促进健康多样性 - 相关研究（F31 - 多样性）应用程序构建是一项随机临床试验，将评估干预措施 减少有阿片类药物过量风险的人的过量风险 该提案的目的是 检查社交网络中非致命和致命用药过量（基线报告）对个人的影响 基线后 6 个月和 12 个月的后续过量风险 F31，受到保护的支持。 动机理论，将通过开发和整合以自我为中心的网络来增加现有的家长资助 评估工具纳入父项目中在基线时进行的现有评估； 评估一个人的社交网络中药物过量的暴露情况以及影响的潜在调节因素 研究还将进行半结构化访谈，以探究和探索影响的潜在中介因素。 社交网络中非致命和致命用药过量对个人用药过量风险的影响，包括风险认知、创伤、 拟议项目的主要成果将是悲伤、社会支持和药品供应中断。 基线后 6 个月和 12 个月自我报告的药物过量率，主要分析将是 补充了基线后 12 个月内发生的非致命过量事件的数据，这将 这项研究将首先利用疾病预防控制中心资助的全州用药过量监测系统来确定。 一项混合方法研究设计，旨在评估社交网络中非致命和致命用药过量对健康的影响 个体用药过量风险并探索所调查效应的潜在调节因素和调节因素。 有用药过量风险的人需要新颖、有针对性和有效的用药过量预防干预措施来缓解 过量风险，拟议的研究完全可以为基于网络的干预策略提供信息。 如果成功，当前的研究可能会提供额外的证据来减少以幸存者为中心的伤害和 向吸毒过量的个人及其社交网络成员提供治疗服务。