Core-005

核心005

• 批准号: 10198074
• 负责人: David H Ellison
• 金额: $ 164.5万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-02 至 2022-08-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10198074
• 关键词: Address; Adopted; Area; Center for Translational Science Activities; Child Health; Clinical; Clinical Research; Development; Disease; Ensure; Ethics; Evaluation; Evolution; Foundations; Funding; Goals; Growth; Health; Human; Impairment; Intervention; Knowledge; Laboratories; Learning Module; Longevity; Mentors; Modeling; Older Population; Oregon; Participant; Performance; Personal Satisfaction; Phenotype; Process; Research; Research Institute; Research Personnel; Resource Sharing; Rural Population; Site; Special Population; Structure; Students; Techniques; Therapeutic; Translational Research; Universities; career development; early phase clinical trial; human disease; improved; informatics tool; patient oriented research; programs; research study; rural underserved; stressor; symposium

OHSU has a robust research portfolio in child health, older populations, diseases across the lifespan, and underserved rural populations. However, there are significant gaps in coordinated support for these important programs that impair optimal performance and expansion of these efforts. The new OCTRI Integrating Special Populations unit (ISP) will enhance research in child health, older populations, diseases across the lifespan, and underserved rural populations with a critical analysis of current needs, development of feasible goals to address these needs, implementation of the highest priority goals, and evaluation and dissemination of the most effective processes. Planned activities include regional conferences and retreats with investigators and other stakeholders, development of toolkits and other educational modules, enhanced informatics tools, and other techniques tailored to each program. The ISP will coordinate closely with the CTSA network to adopt effective techniques developed at other CTSA sites, and to share local proven techniques after careful evaluation. These efforts will enhance knowledge of health-related issues in these special populations, leading to improved interventions to optimize their health and well-being. The OCTRI Clinical and Translational Research Center (CTRC) has greatly expanded and enhanced the conduct of clinical research at OHSU, with unprecedented growth over the past five years. The CTRC also serves as a major site for career development in clinical research at OHSU. However, stressors on CTRC operational and financial structures require a new funding model and increased operational efficiencies. These accomplishments and challenges set the stage for continued evolution of OCTRI’s Participant and Clinical Interactions (PCI) research capacity for the next five years. The CTRC will catalyze scientifically rigorous, ethical, feasible, and efficient patient-oriented research studies, with an emphasis on intensive phenotyping and early phase clinical trials in high priority areas for OHSU investigators. These efforts will advance knowledge of numerous human diseases and lay the foundations for disease-specific therapeutics to enhance human health. The CTRC will also continue to leverage and enhance the OCTRI Educational Program by utilizing the CTRC as the mentored “laboratory” for students, investigators, and study staff pursuing patient- oriented research. Finally, the CTRC will complete its transition to a new operational model as a University Shared Resource (USR), incorporating continuous quality improvement to ensure that sustainable and efficient operational and financial processes are in place to optimally support PCI research at OHSU and the region.

OHSU 在儿童健康、老年人口、整个生命周期的疾病以及 然而，对这些服务不足的农村人口的协调支持存在很大差距。 影响新 OCTRI 最佳绩效和扩展的重要计划。 整合特殊人群单位（ISP）将加强儿童健康、老年人口、疾病方面的研究 整个生命周期和服务不足的农村人口，对当前的需求、发展进行批判性分析 解决这些需求的可行目标、最高优先目标的实施以及评估和 传播最有效的流程，包括区域会议和务虚会。 与调查人员和其他利益相关者一起开发工具包和其他教育模块，增强 信息学工具以及针对每个项目量身定制的其他技术 ISP 将与该项目密切协调。 CTSA 网络采用其他 CTSA 站点开发的有效技术，并共享本地经过验证的技术 经过仔细评估后，这些努力将增强对这些领域健康相关问题的了解。 特殊人群，从而改进干预措施以优化他们的健康和福祉。 OCTRI 临床和转化研究中心 (CTRC) 极大地扩展和增强了 OHSU 开展的临床研究在过去五年中也取得了前所未有的增长。 作为 OHSU 临床研究职业发展的主要场所，CTRC 面临着压力。 业务和财务结构需要新的融资模式并提高运营效率。 这些挑战和挑战为 OCTRI 的参与者和技术的持续发展奠定了基础。 CTRC 未来五年的临床相互作用 (PCI) 研究能力将促进科学发展。 严谨、合乎道德、可行且以患者为中心的研究，重点是强化 OHSU 研究人员在高度优先领域进行表型分析和早期临床试验。 对多种人类疾病的了解和进步为特定疾病的治疗奠定了基础 CTRC 还将继续利用和加强 OCTRI 教育。 利用 CTRC 作为学生、研究人员和研究人员的指导“实验室”的计划 最终，CTRC 将完成以患者为中心的研究的过渡。 模型作为大学共享资源（USR），纳入持续的质量改进以确保 可持续且高效的运营和财务流程已到位，以最佳方式支持 PCI OHSU 和该地区的研究。