SEX DIFFERENCES IN REPOLARIZATION AND EARLY REPOLARIZATION - AIM 3

复极和早期复极的性别差异 - 目标 3

• 批准号: 7604306
• 负责人: Alan H Kadish
• 金额: $ 5.44万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604306
• 关键词: SEX; DIFFERENCES; REPOLARIZATION; EARLY; AIM

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this project, we hypothesize that the level of sex hormones is a major determinant of myocardial repolarization (ST height). The rationale supporting this study is that there are important sex differences in susceptibility to certain arrhtyhmias (irregular heartbeats), suggesting the existence of fundamental electrophysiologic distinctions between males and females. To test our hypothesis, we will examine the relationship between ST height and sex hormone levels in a mixed population of subjects (young and old men and women) without heart disease undergoing hormonal replacement therapy and in subjects not undergoing hormal replacement therapy. Specifically, subjects will be given an echocardiogram (a test using a sound wave that outlines the size of the heart and determines how well the heart is functioning), asked to do an exercise test on a stationary bicycle (which records the heart's electrical activity while the subject is pedaling), undergo, if females with regular menstrual cycles, a urinary ovulation predictor test and give 20ccs of blood to determine several sex hormone levels. We will seek to determine the magnitude of changes in ST variables according to hormone levels changes occuring during the different phases of a normal menstrual cycle and following a long-term sex hormones therapy.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 在这个项目中，我们假设性激素的水平是心肌重极化（ST高）的主要决定因素。 支持这项研究的基本原理是，某些Arrhtyhmias（不规则心跳）的敏感性存在重要的性别差异，这表明男性和女性之间存在基本的电生理学差异。 为了检验我们的假设，我们将研究不接受激素替代治疗的受试者（年轻人和女性）的混合受试者（年轻人和女性）中的ST身高和性激素水平之间的关系，以及未接受荷正替代疗法的受试者。 具体而言，将对受试者进行超声心动图（使用声波测试，概述了心脏大小并确定心脏的运作效果），要求对固定自行车进行运动测试（记录了心脏的电动活动，而在受试者踩踏的情况下），如果女性进行常规的男性测试，以确定卵子的定期级别，并确定卵子的序列，并确定卵子的序列，并确定多个卵形的测试。 我们将寻求根据正常月经周期的不同阶段的激素水平变化以及长期的性激素治疗后的激素水平变化来确定ST变量的变化幅度。