EFFECTS OF CIGARETTE SMOKE ON CYCLOXYGENASE-2 IN ORAL MUCOSA

香烟烟雾对口腔粘膜环加氧酶 2 的影响

• 批准号: 7604208
• 负责人: ANDREW Jess DANNENBERG
• 金额: $ 0.42万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604208
• 关键词: Cheek structure; Cigarette; Computer Retrieval of Information on Scientific Projects Database; Epidermal Growth Factor Receptor; Funding; Grant; Institution; Mucous Membrane; Oral mucous membrane structure; Protein Tyrosine Kinase; Research; Research Personnel; Resources; Smoker; Source; Surface; United States National Institutes of Health; cigarette smoking; cyclooxygenase 2

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Primary Hypothesis: The primary hypothesis of this study is that healthy heavy smokers will express higher levels of cyclooxygenase-2 (COX-2) and related molecules in their oral mucosa. Specific Aims: 1. To evaluate the difference in levels of COX-2 in normal appearing buccal (cheek) mucosa (surface lining of the cheek) between 30 heavy smokers and 30 never smokers. 2. To evaluate the association of pack years of cigarette exposure with levels of COX-2 in normal appearing buccal mucosa of 30 never smokers. 3. To evaluate the difference in levels of activation of epidermal growth factor receptor (EGFR) tyrosine kinase and other related molecules in normal appearing buccal (cheek) mucosa (surface lining of the cheek) between 40 heavy smokers and 40 never smokers.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 主要假设： 这项研究的主要假设是，健康的沉重吸烟者将在口服粘膜中表达更高水平的环氧合酶-2（COX-2）和相关分子。 具体目的： 1。评估正常出现的颊（脸颊）粘膜（脸颊表面衬里）中COX-2水平的差异，在30个浓烟和30位从未吸烟的人之间。 2。为了评估烟气年份暴露年份与COX-2水平的相关性，在正常的颊粘膜中，有30位从未吸烟。 3。为了评估在正常出现的颊（脸颊）粘膜（脸颊表面衬里）中，表皮生长因子受体（EGFR）受体激活水平和其他相关分子之间的激活水平差异。