ANGIOGENESIS AND THE MECHANISMS OF EXERCISE TRAINING IN PAD

PAD 中的血管生成和运动训练机制

• 批准号: 7604401
• 负责人: JUDITH G. REGENSTEINER
• 金额: $ 2.29万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604401
• 关键词: Academic Medical Centers; Address; Age; Antiplatelet Drugs; Atherosclerosis; Blood Vessels; Blood flow; Cardiovascular system; Clinical Research; Colorado; Computer Retrieval of Information on Scientific Projects Database; Evaluation; Exercise; Funding; Gender; Goals; Grant; Health Sciences; Home environment; Impairment; Institution; Leg; Mediating; Modification; Pain; Patients; Performance; Peripheral arterial disease; Pharmacotherapy; Physiology; Randomized; Randomized Controlled Clinical Trials; Recruitment Activity; Research; Research Personnel; Resources; Rest; Risk; Risk Factors; Source; Testing; Training; United States National Institutes of Health; Universities; Walking; Week; Woman; angiogenesis; base; claudication; improved; men; mortality; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Peripheral arterial disease (PAD) impairs arterial blood flow to the legs and is a major indicator of systemic atherosclerosis. Approximately 1/3 of patients with PAD have claudication, defined as pain in one or both legs during walking, that is relieved by rest. Patients with claudication have a marked impairment in exercise performance. Goals of treatment for PAD patients include risk-factor modification and antiplatelet drug therapy to address increased cardiovascular mortality risk. Supervised exercise training is the most efficacious treatment to improve walking capacity, demonstrated in many randomized trials. Neither the physiology of claudication nor the mechanisms by which exercise training improves walking in people with claudication are understood and therefore there is an urgent need for clinical research directed towards defining the basis of the exercise training changes induced in PAD patients. In this stud7, men and women over 40 years, with claudication and an ABI of < .90 at rest will be recruited from Duke University Medical Center and the University of Colorado Health Sciences Center. Patients will be randomized to a supervised or home-based exercise program. Evaluations will be at baseline, 3 weeks (for the supervised exercisers), and at 3 months. Age-gender matched healthy controls will be tested at baseline. The central hypothesis is that the beneficial effects of exercise training are primarily mediated through an angiogenic effect, or the formation of new blood vessels.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 外周动脉疾病（PAD）会损害腿部的动脉血流，是全身动脉粥样硬化的主要指标。 大约 1/3 的 PAD 患者有跛行，即行走时一条腿或双腿疼痛，休息后可缓解。 跛行患者的运动能力明显受损。 PAD 患者的治疗目标包括改变危险因素和抗血小板药物治疗，以解决心血管死亡风险增加的问题。 许多随机试验证明，监督运动训练是提高步行能力的最有效的治疗方法。 跛行的生理学和运动训练改善跛行患者行走的机制均不清楚，因此迫切需要临床研究来确定 PAD 患者运动训练变化的基础。 在这项研究中，将从杜克大学医学中心和科罗拉多大学健康科学中心招募年龄超过 40 岁、患有跛行且静息时 ABI < 0.90 的男性和女性。 患者将被随机分配接受监督或家庭锻炼计划。 评估将在基线、3 周（对于受监督的锻炼者）和 3 个月时进行。 年龄性别匹配的健康对照将在基线时进行测试。 核心假设是运动训练的有益效果主要是通过血管生成效应或新血管的形成来介导的。