California NeuroAIDS Tissue Network

加州神经艾滋病组织网络

基本信息

批准号：
10355434
负责人：
CRISTIAN L ACHIM
金额：
$ 138.27万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-05-01 至 2024-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10355434
关键词：
AIDS/HIV problem Address Age Aging Amyloid beta-Protein Amyloid deposition Antiviral Therapy Autopsy Biological Specimen Banks Biopsy Blood Brain California Cerebrospinal Fluid Cessation of life Characteristics Chronic Clinical Clinical Data Clinical assessments Collaborations Collection Communities Data Data Coordinating Center Data Set Disease Enrollment Equipment and supply inventories Feces Functional disorder Funding Genetic Goals HIV HIV Infections HIV Seronegativity HIV antiretroviral HIV therapy HIV-1 HIV-associated neurocognitive disorder Heart Highly Active Antiretroviral Therapy Individual International Kidney Laboratories Life Liquid substance Liver Longitudinal cohort Lung Lymphoid Tissue Maintenance Methods National NeuroAids Tissue Consortium Neuraxis Neurocognitive Neuropathogenesis Neuropsychology Nucleic Acids Participant Pathologic Peripheral Nervous System Persons Plasma Policies Procedures Protocols documentation Psychiatry Quality Control Research Research Personnel Resources Sampling Site Skin Specimen Standardization Swab Technical Expertise Testis Time Tissue Banks Tissues United States National Institutes of Health Vascular Diseases Viral reservoir Voting age effect antiretroviral therapy clinical research site co-infection cofactor cohort comorbidity data de-identification data exchange data resource design fecal microbiome follow-up interest lymph nodes member microbiome research neuroAIDS neuroimaging prospective quality assurance recruit repository research study response

项目摘要

This is a renewal application for the California NeuroAIDS Tissue Network (CNTN) in response to RFA-MH-18- 250. CNTN is an active participant in the National NeuroAIDS Tissue Consortium (NNTC), a partnership of four NIH-funded neuroAIDS tissue banks. The overarching objectives of the CNTN remains the same today as it was when it was first established in 1998 and encompass the 1) recruitment, clinical assessment, and follow- up of a late-stage HIV cohort, and 2) collection, maintenance, and distribution of specimens to investigators interested in conducting research on the neuropathogenesis of HIV-induced central and peripheral nervous system dysfunction. For the current application, and to address these objectives, CNTN will continue to maintain an in-life cohort of at least 150 participants (mostly people living with HIV/AIDS, PLWHA) with the purpose of obtaining autopsies from high priority cases that are aligned with the three thematic priorities in the RFA: a) HIV eradication from CNS reservoirs; b) mechanisms of HIV-associated neurocognitive disorders (HAND) in the setting of long-term HAART, and c) understanding comorbidities associated with HIV, including the effects of aging and chronic HIV-infection. CNTN will accumulate and manage a bank of in-life (plasma, CSF, blood, stool) and autopsy (brain, heart, lung, liver, kidney, lymph node, blood, and CSF) specimens and data from a cohort of persons living with HIV who are well characterized neuropsychologically, neuromedically, and psychiatrically. CNTN will additionally collect tissues (e.g., gut lymphoid tissue, testes) for emerging CNS cure and eradication research, and stool for microbiome research. Unique within the NNTC, the CNTN has assumed responsibility for CNS HIV-1 Antiretroviral Therapy Effects Research (CHARTER) specimens including plasma, CSF, buccal swabs, skin biopsies, and nucleic acids. De-identified CHARTER data sets (clinical, laboratory, genetic, neuroimaging, and research) have been transferred to the NNTC Data Coordinating Center (DCC), where they are now maintained. CNTN will maintain both the CNTN and CHARTER specimen resource abiding by strict quality assurance and quality control procedures, and will provide timely transfer of data and specimen inventories to the NNTC Data Coordinating Center (DCC). External requests for de-identified CNTN or CHARTER data or specimens are now managed by the DCC in collaboration with NNTC sites, and the CNTN team is well equipped to provide timely distribution of both CNTN and CHARTER specimens according to NNTC data and resource distribution policies. Finally, CNTN will continue to be an active collaborating member of the NNTC by: coordinating with the DCC and other NNTC sites; providing scientific and technical expertise to the wider research community as a voting member of the NNTC Steering Committee (SC), which reviews requests for data and specimens to facilitate neuroAIDS research; and as the leader of the NNTC Neuropsychology/Psychiatry subcommittee. Through the accomplishment of these objectives, the CNTN will continue to be a national and international resource serving the needs of neuroAIDS investigators.

这是加州 NeuroAIDS 组织网络 (CNTN) 响应 RFA-MH-18 的更新申请 - 250. CNTN 是国家神经艾滋病组织联盟（NNTC）的积极参与者，该联盟由四个组织组成 NIH 资助的神经艾滋病组织库。 CNTN 的总体目标至今仍保持不变它于 1998 年首次成立，涵盖 1) 招募、临床评估和后续工作建立晚期 HIV 队列，以及 2) 收集、维护样本并将其分发给研究人员有兴趣进行 HIV 诱导的中枢和周围神经的神经发病机制的研究系统功能障碍。对于当前的应用程序，并为了实现这些目标，CNTN 将继续维持一个现实的队列至少 150 名参与者（主要是艾滋病毒/艾滋病感染者、艾滋病毒感染者），目的是获得尸检结果来自与 RFA 中三个优先主题一致的高度优先案例： a) 根除艾滋病毒中枢神经系统储库； b) 长期HIV相关神经认知障碍（HAND）的机制 HAART，以及 c) 了解与 HIV 相关的合并症，包括衰老和慢性病的影响 HIV感染。 CNTN 将积累和管理生命体（血浆、脑脊液、血液、粪便）和尸检库（脑、心、肺、肝、肾、淋巴结、血液和脑脊液）来自一组人群的样本和数据艾滋病毒感染者，他们在神经心理学、神经医学和精神病学上都有明确的特征。 CNTN将另外收集组织（例如肠道淋巴组织、睾丸）用于新兴的中枢神经系统治疗和根除研究，和用于微生物组研究的粪便。 CNTN 在 NNTC 中独一无二，它承担了 CNS 的责任 HIV-1 抗逆转录病毒治疗效果研究 (CHARTER) 样本，包括血浆、脑脊液、口腔拭子、皮肤活检和核酸。去识别化的 CHARTER 数据集（临床、实验室、遗传、神经影像、和研究）已转移到 NNTC 数据协调中心（DCC），现在在那里维持。 CNTN将严格质量维护CNTN和CHARTER标本资源保证和质量控制程序，并将及时向 NNTC 数据协调中心 (DCC)。外部请求取消识别的 CNTN 或 CHARTER 数据或标本现在由 DCC 与 NNTC 站点合作管理，CNTN 团队状况良好配备根据 NNTC 数据及时分发 CNTN 和 CHARTER 样本的设备资源分配政策。最后，CNTN 将继续作为 NNTC 的积极合作成员通过：与 DCC 和其他 NNTC 站点协调；为更广泛的领域提供科学和技术专业知识研究界作为 NNTC 指导委员会 (SC) 的投票成员，负责审查以下请求：促进神经艾滋病研究的数据和标本；作为 NNTC 的领导者神经心理学/精神病学小组委员会。通过实现这些目标，CNTN 将继续成为国内和国际满足神经艾滋病研究人员需求的资源。