Epidemiology of Dental Caries and Immunity in Children

儿童龋齿流行病学与免疫

• 批准号: 7637476
• 负责人: NOEL K CHILDERS
• 金额: $ 103.03万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-24 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7637476
• 关键词: Age-Months; Alabama; Antibodies; Bacteria; Characteristics; Child; Communicable Diseases; Complex; County; Data; Dental Care; Dental Plaque; Dental caries; Dentists; Development; Dietary Sucrose; Disease; Epidemiologist; Epidemiology; Event; Family; Family member; Genotype; Horizontal Disease Transmission; Host-Parasite Relations; Household and Family; Human; Immunity; Infant; Infection; Intake; Microbial Biofilms; Molar tooth; Mothers; Natural History; Nature; Oral cavity; Oral health; Parasites; Pathogenesis; Physicians; Polymerase Chain Reaction; Population; Preventive; Primary Dentition; Process; Public Health; Pulsed-Field Gel Electrophoresis; Risk; Saliva; Salivary immunoglobulin A; Scientist; Site; Source; Streptococcal Infections; Streptococcus; Streptococcus mutans; Surface; Technology; Time; Tooth eruption; Tooth structure; Underserved Population; Vertical Disease Transmission; age group; deciduous tooth; high risk; improved; oral care; permanent tooth; prevent

DESCRIPTION (provided by applicant): Dental caries is an infectious and transmissible disease worldwide. This disease is multifactorial and complex; however the basic concepts of the host/parasite relationship are important to pathogenesis. Although various bacteria are involved in the disease process, the mutans streptococci (MS) are most consistently implicated in the initiation of caries in humans. Observations in infants indicate that the initial colonization of the oral cavity with MS occurs with eruption of the primary teeth. The normal source of the initial MS infection in young children appears to be vertical transmission from the mother; however, horizontal transmission may also occur from other family members, caretakers or playmates. In addition to the natural history of infection and availability of colonization sites as well as dietary sucrose intake, there is data to indicate that the development of the host's immunity to MS is also involved in MS colonization. Caries in the primary dentition often corresponds with subsequent higher risk for caries in permanent teeth. Therefore, it is necessary to better define important characteristics of MS infections regarding their clonal development and temporal stability within dental plaque biofilms in humans. The purpose of the studies proposed is to investigate the host/parasite relationship important in the pathogenesis and epidemiology of dental caries in a stable and cooperative high caries risk population of families and children of two age groups corresponding with important tooth eruption events (i.e., primary and permanent molar teeth) associated with caries. This proposal utilizes the latest technologies including polymerase chain reaction and pulsed-field gel electrophoresis to establish the commonality of MS genotypes and stability in a defined population of children and family members. An interdisciplinary team of physicians, dentists, basic scientists, epidemiologists and statisticians has been assembled to improve our understanding of the host-parasite relationship of dental caries in children. The results of these studies should provide key information for the development of strategies to prevent this infectious disease. Additionally, the initiation of these studies in Uniontown, Alabama that is in a "Black Belt" county will provide much needed preventive oral care to children and their household family members and will partner with the Alabama Department of Public Health to arrange necessary dental care to improve oral health in this underserved population.

描述（由申请人提供）：龋齿是全球感染性和可传染性疾病。这种疾病是多因素且复杂的。但是，宿主/寄生虫关系的基本概念对发病机理很重要。尽管疾病过程中涉及各种细菌，但Mutans链球菌（MS）最一致地与人类龋齿的启动有关。婴儿的观察结果表明，用MS的口腔初始定植是随着初级牙齿喷发而发生的。幼儿最初的MS感染的正常来源似乎是母亲的垂直传播。但是，水平传播也可能来自其他家庭成员，看护人或玩伴。除了感染的自然史和定殖位点的可用性以及饮食中的摄入量外，还有数据表明，宿主对MS的免疫力的发展也参与了MS定植。初级牙列中的龋齿通常与随后在永久牙齿中龋齿的较高风险相对应。因此，有必要更好地定义MS感染的重要特征，这些特征在人类的牙粒生物膜内的克隆发育和时间稳定性。提出的研究的目的是调查与与龋齿相关的重要牙齿喷发事件（即初级和永久性摩尔牙）的稳定且合作的高龋齿风险人群和两个年龄段的家庭和儿童的牙齿龋齿的发病和流行病学重要的宿主/寄生虫关系。该提案利用最新技术，包括聚合酶链反应和脉冲场凝胶电泳，以确定MS基因型的共同点和稳定性的稳定性。已经组建了一个医师，牙医，基础科学家，流行病学家和统计学家的跨学科团队，以提高我们对儿童牙科龋齿关系的理解。这些研究的结果应为制定预防这种传染病的策略提供关键信息。此外，在阿拉巴马州联合镇的这些研究开始的“黑带”县将为儿童及其家庭成员提供急需的预防性口腔护理，并将与阿拉巴马州公共卫生部合作，以安排必要的牙科护理，以改善这一不足服务的人群的口腔健康。