Efficacy of Laryngeal High-Speed Videoendoscopy

喉高速视频内窥镜的疗效

基本信息

批准号：
7558934
负责人：
DIMITAR D DELIYSKI
金额：
$ 48.15万
依托单位：
UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-02-01 至 2012-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7558934
关键词：
Acoustics Address Adopted Adoption Affect Agreement Area Behavior Behavioral Biomechanics Bite Calibration Characteristics Classification Scheme Clinic Clinical Clinical Protocols Clinical Research Clinical assessments Collaborations Color Complement Computer Simulation Computers Data Databases Detection Devices Diagnosis Diagnostic Endoscopes Evaluation Excision Financial compensation Functional disorder General Hospitals Gold Healthcare Image Image Analysis Imagery Investigation Kymography Larynx Lead Left Length Light Massachusetts Measurement Measures Medial Medical Methods Modeling Motion Participant Pathology Patients Performance Persons Phonation Physiological Presbyterian Church Procedures Production Protocols documentation Recording of previous events Relative (related person)Research Resolution Rotation Sampling Scientist Series South Carolina Speed Stroboscopy Structure System Techniques Technology Testing Training Universities Validation Validity and Reliability Visual Voice Voice Disorders Width base clinical practice clinical research site clinically relevant digital human data improved indexing insight next generation research study simulation sound tool tool development vibration vocal cord

项目摘要

DESCRIPTION (provided by applicant): Voice disorders result from the disruption of normal vocal fold vibration during phonation. The current gold standard for assessing voice disorders is visual endoscopic examination via videostroboscopy. However, technical limitations that are inherent to stroboscopic imaging (i.e., generating a composite image that is assembled across many cycles of vibration) restrict the clinical and research utility of videostroboscopy. High-speed imaging has the potential to capture the true cycle-to-cycle vibratory behavior of the vocal folds, which should theoretically overcome the limitations of videostroboscopy, and provide the potential for more accurate objective quantification of vocal fold vibratory behavior. Vocal fold high-speed imaging has a long research history, and the relatively recent commercial introduction of laryngeal high-speed videoendoscopy (HSV) has served to increase its availability for clinical and research use. However, these HSV systems have not gained widespread adoption because of remaining methodological limitations (eg., compromised image quality; lack of tools to extract the rich visual content, difficulty managing and analyzing the massive amounts of data generated by HSV, etc.), and an associated lack of information regarding the validity, practicality, and clinical relevance of HSV. The primary purpose of this project is to develop improved HSV-based methods for the visualization and automatic measurement of vocal fold vibratory characteristics that will facilitate the clinical and research use of this technology, and to begin establishing the clinical validity, practicality, and relevance of HSV in the functional evaluation of vocal fold pathology. The overriding hypothesis is that HSV can be developed into a robust tool that will provide new insights into the biomechanics of laryngeal sound production (particularly when combined with other simultaneous measures), as well as enable more accurate functional assessment of the pathophysiology of voice disorders leading to important refinements in the diagnosis of vocal fold pathology. The primary purpose requires a series of experiments to improve HSV technology, develop analysis techniques, establish a clinical protocol, collect data, and evaluate the reliability, validity, and relevance of HSV in the clinical assessment of voice disorders. This project proposes a comprehensive approach addressing all of the above tasks, through the collaboration of leading scientists and clinicians.

描述（由申请人提供）：语音障碍是由于发声过程中正常声折振动的中断引起的。当前评估语音疾病的金标准是通过视频镜检查视觉内窥镜检查。但是，频道成像固有的技术局限性（即产生了在许多振动循环中组装的复合图像）限制了视频跨性别镜检查的临床和研究实用性。高速成像具有捕获声带的真实周期到周期振动行为的潜力，从理论上讲，这应该从理论上克服视频镜的局限性，并为更准确的声音折叠振动行为提供了更准确的客观量化。声带高速成像具有悠久的研究史，喉部高速视频镜检查（HSV）的相对较新的商业引入已经增加了其用于临床和研究用途的可用性。但是，由于剩余的方法论上的局限性（例如，图像质量受损；缺乏提取丰富的视觉内容，难以管理和分析HSV产生的大量数据等的工具）以及缺乏有关HSV的有效性，实践和临床相关性的相关信息。该项目的主要目的是开发改进的基于HSV的方法，以可视化和自动测量声带振动特征，以促进该技术的临床和研究使用，并开始建立HSV在声带病理学功能评估中HSV的临床有效性，实用性和相关性。首要假设是，HSV可以发展为可靠的工具，该工具将提供有关喉声产生的生物力学（尤其是与其他同时措施结合使用时）的生物力学，并可以更准确地评估对语音折叠式诊断的语音疾病的病理生理学的病理生理学。主要目的需要一系列实验来改善HSV技术，开发分析技术，建立临床方案，收集数据并评估HSV在语音障碍临床评估中的可靠性，有效性和相关性。该项目提出了一种全面的方法，通过领先的科学家和临床医生的合作来解决上述所有任务。