Graduate Training in Cellular and Molecular Pathogenesis of Human Diseases

人类疾病的细胞和分子发病机制研究生培训

• 批准号: 10187600
• 负责人: Zsuzsanna Fabry
• 金额: $ 29.26万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10187600
• 关键词: Molecular; Pathogenesis; Training; human disease

PROJECT SUMMARY/ABSTRACT The Cellular and Molecular Pathology (CMP) Graduate Training Program is a joint venture of the University of Wisconsin (UW)-Madison Graduate School, the Department of Pathology & Laboratory Medicine and the School of Medicine and Public Health (SMPH). CMP provides rigorous didactic training in fundamental basic biomedical sciences combined with interdisciplinary and innovative training in the pathogenesis of major human diseases. The goal of the CMP program is to create a stimulating and robust intellectual environment for predoctoral training embedded in a dynamic basic and clinical translational research atmosphere in order to develop the skills needed to move biological knowledge toward clinical application. Biomedical Graduate Training for the future demands that first rate academic scientists graduate with appropriate operational, technical and professional skills that will position them for diverse bioscience careers in academia, industry or government. The primary mission of the CMP program is to answer this demand and prepare our graduates for productive careers in the rapidly evolving biomedical research field. The program provides operational (in-depth knowledge, rigorous and reproducible experimental design, critical thinking), technical (teaching state-of-the-art methods, rigor and reproducibility) and professional (career development, IDPs and other opportunities) skills to ensure student success. The overall objective of CMP is to educate trainees so that they have a fundamental knowledge of pathology and molecular medicine, and have an in-depth research experience that combines pathobiological and translational clinical research. CMP’s specific objective is to ensure optimal PhD completion rates and time-to-degree with the implementation of monitored IDPs, student success and progress monitoring. CMP objectives will integrate measurable outcomes the program intends to achieve, such as appropriate completion rates, career placement outcomes and student retention rates. The Program draws 85 PhD, MD/PhD or MD funded faculty trainers from 24 departments. We are requesting training of eight pre-doctoral students under the Molecular Medicine Program. Trainees will be supported in the first or second year of their training. Candidates will be selected based on commitment to research documented by research experience, letters of recommendation and the potential to enhance diversity and make significant contributions toward the health-related research needs of our nation. Our curriculum provides interdisciplinary and integrated training in fundamental concepts in modern pathobiology with an emphasis on biochemical, cellular and molecular approaches to the study of human disease, including training in statistics, rigor and reproducibility and responsible conduct in research. CMP helps students to develop teaching and leadership skills through committee service, presentations and workshop teaching. The proposed program provides the fundamental knowledge base, research experience, and understanding of translational clinical research necessary for the success of our graduates.

项目概要/摘要 细胞和分子病理学（CMP）研究生培训项目是与大学的合资项目 威斯康星大学 (UW)-麦迪逊研究生院、病理学和实验医学系以及 医学与公共卫生学院 (SMPH) 提供严格的基础教学培训。 生物医学科学与重大发病机制的跨学科和创新培训相结合 CMP 项目的目标是创造一个激励性的、强大的智力环境。 在充满活力的基础和临床转化研究氛围中进行博士前培训，以便 培养将生物知识应用于临床应用所需的技能。 未来的培训要求一流的学术科学家在毕业时具备适当的操作、 技术和专业技能将使他们能够在学术界、工业界从事各种生物科学职业 CMP 计划的主要任务是满足这一需求并为我们做好准备。 该计划为毕业生提供了在快速发展的生物医学研究领域从事生产性职业的机会。 操作性（深入的知识、严格且可重复的实验设计、批判性思维）、技术性 （教授最先进的方法、严谨性和可重复性）和专业性（职业发展、国内流离失所者和 其他机会）确保学生成功的技能 CMP 的总体目标是教育学员 具有病理学和分子医学基础知识，并有深入的研究 CMP 的具体目标是结合病理生物学和转化临床研究的经验。 通过实施受监控的国内流离失所者、学生，确保最佳的博士学位完成率和获得学位的时间 CMP 目标将整合该计划旨在实现的可衡量成果。 实现，例如适当的完成率、职业安置结果和学生保留率。 该计划吸引了来自 24 个院系的 85 名博士、医学博士/博士或医学博士资助的教员培训师。 将支持分子医学计划下八名博士前学生的培训。 培训第一年或第二年将根据对研究的承诺来选择。 通过研究经验、推荐信和增强多样性的潜力来记录 我们的课程为我们国家的健康相关研究需求做出了重大贡献。 现代病理学基本概念的跨学科和综合培训，重点是 研究人类疾病的生物化学、细胞和分子方法，包括统计学培训， CMP 的严谨性、可重复性和负责任的行为有助于学生发展教学和研究。 通过委员会服务、演讲和研讨会教学的领导技能。 提供基础知识基础、研究经验和对转化临床的理解 我们的毕业生取得成功所必需的研究。