Early and Mid-Life Social Determinants of Racial Disparities in Late-Life Health

晚年健康种族差异的早年和中年社会决定因素

• 批准号: 7689292
• 负责人: CARLOS F. MENDES DE LEON
• 金额: $ 45.63万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7689292
• 关键词: Accounting; Address; Age; Aging; Biological; Biological Factors; Birth; Blood Pressure; Blood specimen; C-reactive protein; Censuses; Cerebrovascular Disorders; Chicago; Childhood; Classification; Clinical; Clinical Markers; Cohort Studies; Collection; County; Data; Data Collection; Education; Elderly; Environment; Epidemiologic Studies; Foundations; Glycosylated Hemoglobin; Glycosylated hemoglobin A; Goals; Health; Hypertension; Impaired cognition; Infarction; Inflammation; Interleukin-6; Life; Measures; Mediating; Neighborhoods; Occupational Status; Older Population; Outcome; Patient Self-Report; Pattern; Policies; Population; Prevention; Race; Resources; Role; Series; Social Conditions; Social Functioning; Socioeconomic Status; Specimen; Staging; Testing; Urban Population; Work; cohort; disability; early experience; experience; glycemic control; health disparity; interest; middle age; public health relevance; racial difference; secondary outcome; segregation; social; white matter

DESCRIPTION (provided by applicant): The overall goal of the proposed study is to examine childhood and mid-life adulthood social determinants of health disparities between older blacks and whites. The study will assess racial disparities in late-life health in four biological outcomes: blood pressure, glycemic control, sub-clinical cerebrovascular disease, and inflammation. These outcomes were selected because of their relevance for racial disparities in health and the prevention of late-life disability and cognitive impairment. The study will focus on personal social resources (e.g., education, occupational status), and residential environment social conditions (e.g., birth county level of socio-economic status, neighborhood segregation during adulthood), and examine the degree to which these social resources and conditions experienced prior to older age account for racial disparities in late-life health. The study will also test whether racial disparities in late-life health ablood specimens in this population which are needed to obtain a measure of glycemic control. Despite general improvements in overall health among older adults in the US, racial disparities in late-life health continue to be large and pervasive. Racial differences in social resources and conditions in earlier stages of life are likely to be an important factor in alleviating these disparities. Findings from this study will provide a better understanding of the social and biological mechanisms that contribute to racial disparities in late-life health, creating a foundation for policies and strategies to reduce and ultimately eliminate health disparities between older blacks and whites. PUBLIC HEALTH RELEVANCE: Despite general improvements in overall health among older adults in the US, racial disparities in late-life health continue to be large and pervasive. Racial differences in late- life health are likely to depend on social resources and conditions experienced earlier in life, butmportance to the prevention of disability and cognitive impairment in old age. An important strength of the study is that it will take advantage of the availability of detailed information on most social and biological factors of interest. This information is derived from an ongoing cohort study in a large population of older blacks and whites. Findings from this study are expected to provide a better understanding of the social and biological mechanisms that contribute to racial disparities in late-life health, creating a foundation for policies and strategies to reduce and ultimately eliminate health disparities between older blacks and whites.

描述（由申请人提供）：拟议的研究的总体目标是检查童年和中年成年社会决定因素，即老年黑人和白人之间健康差异。该研究将评估四种生物学结果的晚期健康状况的种族差异：血压，血糖控制，临床下脑血管疾病和炎症。之所以选择这些结果是因为它们与健康方面的种族差异以及预防晚期残疾和认知障碍的相关性。该研究将侧重于个人社会资源（例如，教育，职业地位）和住宅环境社会状况（例如，出生县的社会经济地位，成年期间的邻里隔离），并研究这些社会资源和晚期健康差异的年龄差异之前经历的这些社会资源和条件的程度。该研究还将测试该人群中晚期健康阿布洛德标本中是否需要获得血糖控制的种族差异。尽管美国老年人的整体健康状况有所改善，但后期健康的种族差异仍然很大且普遍存在。在生活的早期阶段，社会资源和条件上的种族差异可能是减轻这些差异的重要因素。这项研究的结果将更好地理解促成晚年健康中种族差异的社会和生物学机制，从而为减少和最终消除老年黑人和白人之间的健康差异的政策和策略奠定了基础。公共卫生相关性：尽管美国老年人的整体健康状况有所改善，但后期健康的种族差异仍然很大且普遍存在。晚期健康状况的种族差异可能取决于社会资源和生活中早期经历的状况，但最重要的是预防老年人的残疾和认知障碍。该研究的一个重要优势在于，它将利用有关大多数社会和生物学因素的详细信息的可用性。该信息来自正在进行的队列研究中，大量的老年黑人和白人。预计这项研究的发现将更好地理解促成晚年健康状况的种族差异的社会和生物学机制，从而为减少和最终消除老年黑人和白人之间的健康差异的政策和策略创造了基础。