Center of Excellence in Environmental Toxicology

环境毒理学卓越中心

• 批准号: 7393343
• 负责人: Trevor M Penning
• 金额: $ 104.33万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-13 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7393343
• 关键词: Center; Excellence; Environmental; Toxicology

DESCRIPTION (provided by applicant) This is a revised application to establish a NIEHS Center in Environmental Health Sciences at the University of Pennsylvania. The Center will hold the title: "Center for Excellence in Environmental Toxicology (CEET)". It will be the single entity that coordinates, facilitates, synergizes and integrates all environmentally related health research and outreach at the University. The CEET has identified 50 faculty members in 16 Departments from 5 Schools as Center members. These members are dedicated to the CEET mission, which is: to improve the health of the public living in urban environments with an aging industrial infrastructure, through basic, translational and clinical research, and outreach. The investigators will relate environmental exposures, to molecular/cellular effects, to health outcomes, with the vision that diseases with environmental etiology can be largely eliminated by effective prevention or intervention strategies and/or changes in environmental policy. The mission will be accomplished via four integrated Research Cores, three Facility Cores, and a vibrant Community Outreach and Education Program (COEP). The Research Cores are led by investigators with international reputations. These Cores are in Oxidative Stress and Oxidative Stress Injury (co-Directors: Drs. Blair and Ischiropoulos), Endocrine and Reproduction Disruption (co-Directors: Drs. Strauss and Manson), Lung and Airway Disease (co-Directors: Drs. Panettieri and Albelda), and Genes and the Environment (co-Directors: Drs. Rebbeck and Whitehead). These Cores address environmental health issues important to our urban region. Adverse reproductive and pregnancy outcomes, developmental disorders, and diseases of the lung and airway are common, and are addressed in the organ-based Cores. The Cores in Oxidative Stress and Genes in the Environment will elucidate key mechanisms by which environmental exposures can lead to toxicity in these and other organ systems leading to an integrated Center structure. The Facility Cores will be in Toxicogenomics, Toxicoproteomics and Biomarkers, and will provide investigators with services that would otherwise be unattainable and will propel investigators into the new era of predictive toxicology. The COEP will disseminate the research findings and utilize the expertise of CEET investigators: to enhance K-16 education in environmental health; to conduct community outreach in four environmentally challenged Southeastern Pennsylvania communities, and to enrich the education of health care professionals. The COEP has forged relationships with community partners for outreach. The COEP goal will be to reduce the risk of harmful exposures and improve the public health of vulnerable populations within these communities.

描述（由申请人提供） 这是在宾夕法尼亚大学建立NIEHS环境健康科学中心的修订申请。该中心将拥有标题：“环境毒理学卓越中心（CEET）”。 它将是单一的实体，可以协调，促进，协同和整合所有与环境相关的健康研究和外展。 CEET已确定5名来自5所学校的16个部门的教职员工为中心成员。这些成员致力于CEET任务，这是：通过基本，转化和临床研究以及外展活动改善生活在具有衰老的工业基础设施的城市环境中的公众健康。研究人员将将环境暴露与分子/细胞影响与健康结果联系起来，即通过有效的预防或干预策略和/或环境政策的变化可以在很大程度上消除具有环境病因的疾病的愿景。该任务将通过四个综合研究核心，三个设施核心以及一个充满活力的社区外展和教育计划（COEP）来完成。 研究核心由具有国际声誉的调查员领导。 These Cores are in Oxidative Stress and Oxidative Stress Injury (co-Directors: Drs. Blair and Ischiropoulos), Endocrine and Reproduction Disruption (co-Directors: Drs. Strauss and Manson), Lung and Airway Disease (co-Directors: Drs. Panettieri and Albelda), and Genes and the Environment (co-Directors: Drs. Rebbeck and Whitehead). 这些核心解决了对我们城市地区重要的环境健康问题。 肺和气道的不良生殖和妊娠结局，发育障碍以及疾病很常见，并在基于器官的核心中解决。 氧化应激中的核心和环境中的基因将阐明关键机制，通过这些机制，环境暴露可以导致这些和其他器官系统的毒性导致综合中心结构。该设施核心将用于毒理基因组学，有毒蛋白质组学和生物标志物，并将为研究人员提供否则无法实现的服务，并将推动研究人员进入预测毒理学的新时代。 COEP将传播研究结果并利用CEET研究人员的专业知识：增强K-16环境健康教育；在宾夕法尼亚州东南部的四个环境挑战中进行社区宣传，并丰富医疗保健专业人员的教育。 COEP与社区合作伙伴建立了宣传关系。 COEP的目标是减少有害暴露的风险，并改善这些社区内脆弱人群的公共健康。