SIGNALING AND ACTIN NUCELATION

信号传导和肌动蛋白成核

• 批准号: 7602381
• 负责人: BRUCE J. MAYER
• 金额: $ 2.13万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7602381
• 关键词: Actins; Behavior; Binding; Biological Models; Cells; Complex; Computer Retrieval of Information on Scientific Projects Database; Cytoskeletal Modeling; Funding; Grant; Institution; Research; Research Personnel; Resources; Signal Transduction; Site; Source; Tail; United States National Institutes of Health; polymerization; receptor; virtual

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Nck molecule has emerged as an important regulator of receptor activated cytoskeletal reorganization. In particular, aggregation of a receptor complex containing a nNck binding domain produces comet tails of actin polymerization at the site of aggregation. We will model this system with the Virtual Cell in an effort to dissect th complex signaling network underlying this behavior

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 NCK分子已成为受体激活的细胞骨架重组的重要调节剂。特别是，含有NNCK结合结构域的受体复合物的聚集会在聚集部位产生肌动蛋白聚合的彗星尾部。我们将使用虚拟单元对该系统进行建模