SODIUM MRI OF THE BRAIN OF PATIENTS WITH ALZHEIMER?S DISEASE

阿尔茨海默病患者脑部的钠 MRI

• 批准号: 7600825
• 负责人: Eric Albert Mellon
• 金额: $ 1.65万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7600825
• 关键词: Affect; Alzheimer' s Disease; American; Brain; Computer Retrieval of Information on Scientific Projects Database; Development; Diagnosis; Diagnostic Imaging; Disease; Elderly; Faculty; Funding; Goals; Grant; Health Care Costs; Individual; Institution; Lead; Magnetic Resonance Imaging; Memory Loss; Monitor; Neurons; Parietal Lobe; Patients; Psyche structure; Research; Research Personnel; Resources; Senile Plaques; Signal Transduction; Sodium; Source; Therapeutic; United States National Institutes of Health; improved; interest; outcome forecast; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research involves development of Sodium MR Imaging for detecting changes in sodium in the Beta-Amyloid Plaques. Alzheimers Disease (AD) is a devastating and relatively common disease resulting in loss of memory and mental faculties in the affected elderly individual. Upwards of 2 million elderly Americans have AD and this results in a total health care cost of >$50 billion dollars annually. There is significant interest in the diagnostic imaging of AD for the goal of improved diagnosis, prognosis, and monitoring of therapeutic responses to treatment. Pathologically, AD is marked in part by a loss of neural cells and formation of amyloid-beta plaques, primarily in the frontal and parietal lobes. We hypothesize that these changes would lead to an increase in sodium signal by two mechanisms.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究涉及开发MR成像的发展，以检测β-淀粉样蛋白斑中钠的变化。 阿尔茨海默氏病（AD）是一种毁灭性且相对常见的疾病，导致受影响的老年人的记忆和心理能力丧失。超过200万美国人拥有广告，这导致医疗保健总费用> 500亿美元。对于改善诊断，预后和监测治疗治疗反应的目的，对AD的诊断成像引起了巨大兴趣。从病理上讲，AD部分由神经细胞的丧失和淀粉样β斑块的形成，主要是在额叶和顶叶。我们假设这些变化将通过两种机制导致钠信号的增加。