SODIUM MRI OF THE BRAIN OF PATIENTS WITH ALZHEIMER?S DISEASE

阿尔茨海默病患者脑部的钠 MRI

• 批准号: 7723812
• 负责人: Eric Albert Mellon
• 金额: $ 2.72万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7723812
• 关键词: Age; Alzheimer' s Disease; Brain; Brain scan; Cell Death; Computer Retrieval of Information on Scientific Projects Database; Development; Diagnosis; Disease; Funding; Grant; Histologic; Institution; Invasive; Magnetic Resonance Imaging; Measurement; Measures; Neurons; Participant; Patients; Personal Satisfaction; Research; Research Personnel; Resources; Sodium; Source; Techniques; Testing; United States National Institutes of Health; base; interest; nervous system disorder; novel; outcome forecast; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is significant interest in the development of novel non-invasive techniques for the diagnosis of Alzheimer disease (AD) and tracking its progression. Because magnetic resonance imaging (MRI) is non-invasive and routinely performed in the setting of neurological disease, implementation of new MRI-based techniques for the diagnosis and prognosis of AD are especially advantageous. Since sodium (23Na) MRI has been shown to be sensitive to cell death and viability, we tested whether early changes would be seen in Alzheimer disease, a disease where neural cell death has been well established.For these studies we compare measurements made with sodium MRI with conventional brain scanning in age-matched participants with and without AD. We also measure sodium measures on brains willed to us from deceased AD patients and compare that with histologic measures of disease. So far we have demonstrated differences in sodium MRI that seem to correlate better with the presence of mild AD than conventional markers. Ongoing studies hope to reproduce this effect in larger groups of patients and further understand the underlying mechanism of this phenomenon. It is hoped that with further study sodium MRI may be a useful tool for the quantitative diagnosis and disease tracking of AD.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 人们对开发新型非侵入性技术的兴趣很大，以诊断 阿尔茨海默氏病（AD）并跟踪其进展。因为磁共振成像（MRI）为 在神经疾病的环境中进行无创和常规执行，实施新的 基于MRI的AD诊断和预后技术特别有利。自从 钠（23NA）MRI已显示对细胞死亡和生存能力敏感，我们测试了是否测试 在阿尔茨海默氏病中可以看到早期变化，这种疾病是神经细胞死亡的疾病 为了这些研究，我们比较了用钠MRI和常规的测量 有或没有AD的年龄匹配的参与者进行大脑扫描。我们还测量钠 对我们的大脑措施从已故的AD患者那里愿意给我们，并将其与组织学比较 疾病措施。到目前为止，我们已经证明了钠MRI的差异 与传统标记相比，与温和广告的存在更好。正在进行的研究希望 在较大的患者中重现这种效果，并进一步了解基础 这种现象的机制。希望有进一步的研究钠MRI可能是 用于广告的定量诊断和疾病跟踪的有用工具。