CRYSTALLOGRAPHIC STUDIES OF GLUTAMINE SYNTHETASE AND TNRA FROM BACILLUS SUBTILIS

枯草芽孢杆菌谷氨酰胺合成酶和 TNRA 的晶体学研究

• 批准号: 7597986
• 负责人: RICHARD GERALD BRENNAN
• 金额: $ 0.02万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7597986
• 关键词: Amino Acids; Ammonia; Bacillus subtilis; Bacteria; Cells; Computer Retrieval of Information on Scientific Projects Database; DNA; Elements; Environment; Enzymes; Funding; Glutamate-Ammonia Ligase; Glutamates; Glutamine; Grant; Growth; Indium; Institution; Metabolic; Nitrogen; Nutrient; Production; Proteins; Regulation; Research; Research Personnel; Resources; Signal Transduction; Source; United States National Institutes of Health; Variant

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Bacterial cells have an extraordinary ability to sense and respond to various changes in their environment. These cells need to detect and correctly respond to extreme variations, such as a dramatic change in essential nutrients. One very important nutrient is nitrogen, which is a key element in the production of DNA, amino acids for proteins, and many other cellular elements. Most bacteria use the amino acid glutamine as a metabolic signal for availability of nitrogen in the environment. In turn, the enzyme that produces glutamine from glutamate and ammonia, glutamine synthetase (GS), is the major target of regulation during nitrogen-limited growth.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 细菌细胞具有特殊的感知和应对环境变化的能力。 这些细胞需要检测并正确响应极端变化，例如必需营养素的急剧变化。 一种非常重要的营养是氮，它是DNA产生，蛋白质氨基酸的关键元素，以及许多其他细胞元素。 大多数细菌都使用氨基酸谷氨酰胺作为代谢信号，以在环境中获得氮。 反过来，从谷氨酸和氨，谷氨酰胺合成酶（GS）产生谷氨酰胺的酶是在氮限制生长过程中调节的主要靶标。