MRI of weak periodic currents using balanced Steady State Free Precession

使用平衡稳态自由进动的弱周期电流 MRI

• 批准号: 7644307
• 负责人: GIEDRIUS T BURACAS
• 金额: $ 19.31万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7644307
• 关键词: Achievement; Acoustic Stimulation; Address; Affect; Animals; Arteriogram; Blood Vessels; Brain; Brain imaging; Caffeine; Carbon Dioxide; Cardiac; Cerebrovascular Circulation; Cerebrum; Characteristics; Computer Simulation; Coupling; Data; Detection; Electromagnetics; Equilibrium; Financial compensation; Frequencies; Goals; Head; Heating; Human; Image; Magnetic Resonance Imaging; Magnetoencephalography; Measures; Metabolic; Methods; Motion; Neuromodulator; Neurons; Noise; Pattern; Phase; Physiologic pulse; Physiological; Problem Solving; Protocols documentation; Radio; Rattus; Reporting; Research; Resolution; Respiration; Scanning; Signal Transduction; Source; Spin Labels; Stimulus; Techniques; Testing; Time; Variant; Vibrissae; Visual; base; blood oxygen level dependent; blood oxygenation level dependent response; imaging modality; in vivo; magnetic field; public health relevance; relating to nervous system; research study; respiratory; response; theories

DESCRIPTION (provided by applicant): Existing functional brain MR imaging methods such as blood oxygenation level dependent (BOLD) imaging are based on vascular and metabolic responses to variations in underlying neuronal activity and thus reflect the latter only indirectly. It has been proposed (e.g. Bodurka & Bandettini, 2002) that magnetic field perturbations caused by neuronal currents in the brain in principle ought to be detectable by means of MRI. Several research groups have demonstrated the feasibility of this idea in theory, electric current phantoms and in vivo. However, relatively low signal-to-noise ratio achieved to date renders existing methods impractical. Balanced Steady State Free Precession (bSSFP, also known as TrueFISP, FIESTA) pulse sequence is unique in that it can afford the highest known SNR per unit time and thus application of bSSFP for functional neural current imaging can potentially solve the problem of low SNR. Recent studies suggest that certain SSFP sequences might be exquisitely sensitive to minute periodic perturbations of the spin phase. Thus, periodic currents locked to RF excitation pulse result in an alternating balanced steady state (ABSS) that can effectively amplify the phase offset induced by currents. Our theoretical calculations and the data acquired with bSSFP at 3T using a current phantom indicates SNR of the signal induced by periodic currents that is substantially superior to that achieved previously using standard gradient and spin echo imaging (Buracas et al., 2007). We propose to develop optimized alternating steady-state imaging protocols for imaging of periodic electric currents. First, we will optimize, analytically, in computer simulations, and current phantom experiments the sensitivity of the ABSS method to weak periodic currents and address the impact of various sources of noise on the ABSS signal. Next, we will apply this method to imaging neuronal currents in vivo (using rat whisker stimulation and human audiovisual stimulation paradigms). We will implement noise compensation for magnetic field fluctuation due to respiration and scanner drift and motion compensation. In conclusion, the current proposal will address the possibility to measure electromagnetic correlates of cerebral neuronal activity by means of ABSS and will address critical sources of noise. Accomplishment of the proposed aims has a potential of introducing a new imaging modality for functional brain imaging - high resolution MRI-based magnetoencephalography. PUBLIC HEALTH RELEVANCE: Established functional brain MR imaging methods are susceptible to factors influencing neurovascular coupling. It has been recently proposed and demonstrated that MRI can be used for imaging neuronal currents directly, but existing methods are impractical due to their low SNR. The proposed research will develop ultra- sensitive MRI methods for imaging neuronal currents using balanced Steady State Free Precession pulse sequences that possess best known SNR efficiency.

描述（由申请人提供）：现有的功能性脑MR成像方法，例如血氧水平依赖性（BOLD）成像，是基于血管和代谢对潜在神经元活动变化的反应，因此仅间接反映后者。有人提出（例如 Bodurka & Bandettini，2002），原则上应该可以通过 MRI 检测到大脑中神经元电流引起的磁场扰动。几个研究小组已经证明了这一想法在理论上、电流模型和体内的可行性。然而，迄今为止实现的相对较低的信噪比使得现有方法不切实际。平衡稳态自由进动（bSSFP，也称为TrueFISP、FIESTA）脉冲序列的独特之处在于它可以提供单位时间内已知的最高SNR，因此将bSSFP应用于功能神经电流成像可以潜在地解决低SNR的问题。最近的研究表明，某些 SSFP 序列可能对自旋相的微小周期性扰动极其敏感。因此，锁定到射频激励脉冲的周期性电流会产生交替平衡稳态（ABSS），可以有效地放大电流引起的相位偏移。我们的理论计算和使用电流体模在 3T 下通过 bSSFP 采集的数据表明，周期性电流引起的信号的信噪比明显优于之前使用标准梯度和自旋回波成像所获得的信噪比（Buracas 等，2007）。我们建议开发用于周期性电流成像的优化交替稳态成像协议。首先，我们将在计算机模拟和电流模型实验中分析优化ABSS方法对弱周期电流的灵敏度，并解决各种噪声源对ABSS信号的影响。接下来，我们将应用这种方法对体内神经元电流进行成像（使用大鼠胡须刺激和人类视听刺激范例）。我们将对呼吸和扫描仪漂移引起的磁场波动进行噪声补偿以及运动补偿。总之，当前的提案将解决通过 ABSS 测量脑神经元活动的电磁相关性的可能性，并将解决关键的噪声源。实现所提出的目标有可能为功能性脑成像引入一种新的成像方式——基于高分辨率 MRI 的脑磁图。公共健康相关性：已建立的功能性脑 MR 成像方法容易受到影响神经血管耦合的因素的影响。最近提出并证明 MRI 可用于直接对神经元电流进行成像，但现有方法由于信噪比低而不切实际。拟议的研究将开发超灵敏的 MRI 方法，使用具有最著名的 SNR 效率的平衡稳态自由进动脉冲序列对神经元电流进行成像。

项目成果

On multiple alternating steady states induced by periodic spin phase perturbation waveforms.

关于由周期性自旋相位扰动波形引起的多个交替稳态。

• DOI: 10.1002/mrm.23105
• 发表时间: 2012
• 期刊: Magnetic resonance in medicine
• 影响因子: 3.3
• 作者: Buračas,GiedriusT;Jung,Youngkyoo;Lee,Jongho;Buxton,RichardB;Wong,EricC;Liu,ThomasT
• 通讯作者: Liu,ThomasT