Multichannel Coils and Motion Correction for Developing Brain

用于大脑发育的多通道线圈和运动校正

• 批准号: 7692942
• 负责人: Patricia Ellen Grant
• 金额: $ 22.11万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7692942
• 关键词: 1 year old; 4 year old; 5 year old; Acceleration; Adult; Age; Anesthesia procedures; Archives; Arts; Autistic Disorder; Behavioral; Brain; Brain Diseases; Caring; Categories; Child; Childhood; Clinical; Cognitive deficits; Consent; Coupled; Coupling; Data; Development; Diagnostic; Diffusion Magnetic Resonance Imaging; Disease; Enabling Factors; Epilepsy; Evaluation; Fatty acid glycerol esters; Genetic; Goals; Growth and Development function; Head; Helmet; Image; Infant; Injury; Instruction; Life; Magnetic Resonance Imaging; Methods; Modality; Morphologic artifacts; Motion; Neurons; Noise; Nurses; Parents; Patients; Performance; Phase; Physicians; Physiologic pulse; Population; Preparation; Probability; Protocols documentation; Radiation; Risk; Scanning; Sedation procedure; Structure; Techniques; Technology; Testing; Thick; Time; Tissues; Trauma; Traumatic Brain Injury; Vendor; Vulnerable Populations; Water; abstracting; base; cost; cranium; design; developmental disease; flexibility; improved; myelination; neonate; public health relevance; rapid growth; safety testing; success; tumor; water diffusion

DESCRIPTION (provided by applicant): Abstract Pediatric brain disorders such as trauma, tumors, epilepsy, autism and other developmental disorders are common in children less than 5 years. These first 5 years of life are also key in the developing brain as neuronal specification and myelination occurs. During this time of rapid growth and development the brain is highly vulnerable to injury, exposures or errors in genetic expression. As with adults, MR imaging is the modality of choice for evaluating the pediatric brain yet the pediatric population is currently underserved by commercial vendors. None of the major vendors provide state-of-the-art pediatric sized head coils and third party vendors that do, use outdated technology. Due to the long scan times and likelihood of motion artifacts, MR requires sedation or anesthesia. In addition sedation and anesthesia come with risks of their own, particularly in the very young, reduces the availability of MR and increases the cost of MR scanning. As a result CT is often chosen for even though it is particularly insensitive to parenchymal abnormalities in the immature brain and comes with increased risk of radiation induced cognitive deficits. The overall goal of this project is to create age specific 32 channel head coils and accelerated motion insensitive pulse sequences which allow high quality sedation free scanning in 15 minutes for children less than 5 years of age. The specific aims of this project are: Specific Aim 1: Design, develop and test 32 channel head coils for term infants, 6 month olds, 1 year olds and 2 - 4 year olds. Specific Aim 2: Design, develop and test motion insensitive sequences for T1 (3D FLASH) and T2 (T2 SPACE) contrast as well as Diffusion Tensor Imaging (DTI). Specific Aim 3: Perform a real world test of this motion insensitive accelerated protocol in 20 children less than 5 years of age. Age appropriate behavioral methods will be used to help the children undergo the 15 minute scan. We expect that these advances in coil technology and motion correction will significantly reduce imaging time and make pediatric MR imaging without sedation or anesthesia more feasible and there make MR imaging more available to our youngest and most vulnerable patients. PUBLIC HEALTH RELEVANCE: MR imaging is the safest and most sensitive modality for assessing brain abnormalities yet in young children because of the need for sedation or anesthesia, the risk is increased, the availability is limited and the expense is high. Decreasing scan times with pediatric specific multichannel head coils and designing motion insensitive pulse sequences would allow complete evaluation in 15 minutes instead of the current 45 minutes. These advances combined with age appropriate behavioral techniques has a high probability of making sedation free scanning possible in this young and vulnerable population.

描述（由申请人提供）：抽象的小儿脑疾病，例如创伤，肿瘤，癫痫，自闭症和其他发育障碍，在不到5年的儿童中很常见。 随着神经元规范和髓鞘形式发生，生命的前5年也是发展中大脑的关键。 在这一快速增长和发育的时期，大脑非常容易受到损伤，遗传表达中的暴露或错误。 与成年人一样，MR成像是评估小儿大脑的首选方式，但小儿种群目前由商业供应商服务。 没有一个主要的供应商提供最先进的儿科大小的头圈和使用过时技术的第三方供应商。 由于扫描时间很长和运动伪影的可能性，MR需要镇静或麻醉。 此外，镇静和麻醉还带有自己的风险，尤其是在年轻的年轻人中，可以降低MR的可用性，并增加MR扫描的成本。 结果，即使它对未成熟大脑的实质异常不敏感，并且会增加辐射诱导的认知缺陷的风险，但通常会选择CT。 该项目的总体目标是创建特定年龄的32通道头线圈和加速运动不敏感的脉冲序列，从而可以在15分钟内为不到5岁以下的儿童提供高质量的镇静扫描。 该项目的具体目的是：特定目标1：设计，开发和测试32个频道头线线圈，适用于儿童，6个月大，1岁和2-4岁的孩子。 特定目标2：设计，开发和测试运动运动不敏感的序列（3D闪存）和T2（T2空间）对比度以及扩散张量成像（DTI）。 特定目标3：对20岁以下的20名儿童进行这种运动不敏感的加速方案的现实测试。 年龄适当的行为方法将用于帮助孩子接受15分钟的扫描。 我们预计，这些线圈技术和运动校正方面的进步将大大减少成像时间，并使小儿MR成像无镇静或麻醉更可行，并且在那里使MR成像更适合我们最年轻，最脆弱的患者使用。 公共卫生相关性：MR成像是评估脑部异常的最安全，最敏感的方式，但由于需要镇静或麻醉，风险增加，可用性有限，费用很高。 通过小儿特异性多通道头线圈和设计运动不敏感的脉冲序列减少扫描时间，将允许在15分钟内完成完整的评估，而不是当前的45分钟。 这些进步与适当的行为技术相结合，在这个年轻和脆弱的人群中可以使镇静无扫描成为可能。