Advancing Geriatrics Infrastructure & Network Growth (AGING) Initiative

推进老年病学基础设施

基本信息

批准号：
9922192
负责人：
JERRY H GURWITZ
金额：
$ 73万
依托单位：
UNIV OF MASSACHUSETTS MED SCH WORCESTER
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-01 至 2023-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9922192
关键词：
Address Advisory Committees Aging American Award Capsicum Caring Chronic Clinical Research Clinical Trials Design Collaborations Data Development Disease Elderly Electronic Health Record Etiology Exploratory/Developmental Grants Phase II Fostering Foundations Funding Funding Opportunities Geriatrics Grant Growth Healthcare Systems Infrastructure Interdisciplinary Study Intervention Measurement Mentors Methods Minority Groups Monoclonal Antibody R24 National Institute on Aging Network Infrastructure Observational Study Older Population Patient Care Patients Persons Pilot Projects Population Pragmatic clinical trial Prevention Process Quality of Care Research Research Methodology Research Personnel Research Priority Research Support Resources Science Scientist Series Site Speed Testing Translating Underrepresented Groups Underrepresented Minority Universities base care outcomes care systems career career development clinical decision-making clinical practice cohort cost data resource health care delivery human old age (65+)improved innovation interest multidisciplinary multiple chronic conditions novel patient oriented patient population preference programs success systems research

项目摘要

PROJECT SUMMARY / ABSTRACT The Health Care Systems Research Network (HCSRN)-Older Americans Independence Centers (OAICs) AGING (Advancing Geriatrics Infrastructure and Network Growth) Initiative, funded under an R24 grant mechanism (R24 AG045050), was initiated in 2014 to foster collaborations between HCSRN and OAIC (aka Pepper Centers) investigators in order to advance an interdisciplinary research agenda focused on advancing the science of multiple chronic conditions (MCCs) in older adults. The AGING Initiative is a highly productive, collaborative, transdisciplinary endeavor involving scientists from 18 HCSRN research centers, embedded within healthcare delivery systems caring for nearly 2 million persons aged 65 and older, in partnership with investigators from 15 premier, university-based centers established by the National Institute on Aging (the OAICs). Under the R24, efforts relevant to advancing MCCs science have centered around: (1) characterizing and sharing unique data resources; (2) supporting innovative, collaborative pilot projects; (3) mentoring new and early-stage investigators; and (4) disseminating research methods and findings. This collaboration has identified several understudied, high priority research domains, as well as an urgent need for formal career development support for new and early-stage scientists committed to aging research on etiology, prevention, and treatment, relevant to the care of older persons with MCCs. The overarching aim of our expanded R33 program, conceived and developed by the R24 HCSRN-OAICs AGING Initiative Steering Committee, and its Workgroups and External Advisory Committee, is to elaborate on the successful programs and infrastructure of the R24, while taking our AGING Initiative in new, more ambitious directions. We will create new core resources, career development opportunities, and funding opportunities, aligning patients' interests with those of scientists. Our specific aims are: (1) to expand on and further develop innovative methods related to measurement and analytics, observational research, and pragmatic clinical trial design and implementation, to inform the development and testing of novel interventions that improve the care and outcomes of older persons with MCCs; (2) to foster the career development and success of new and early-stage investigators, including underrepresented minorities, and create a nation-wide cohort of MCCs scholars, who are prepared to establish productive collaborations early in their careers to catalyze an expansion of interdisciplinary research relevant to the science of MCCs; (3) to create a new core function as part of an elaborated infrastructure that promotes patient-centered research by engaging patients and care partners in all stages of the research process; and (4) to fund a series of “P-2-R” (“Pilot-to-R award”) grants that will advance the R33 research priorities relevant to the science of MCCs. The “P-2-R” grants will serve to promote the development and implementation of larger, multi-disciplinary, multi-site studies laying a foundation upon which to continue to grow the AGING Initiative.

项目概要/摘要医疗保健系统研究网络 (HCSRN)-美国老年人独立中心 (OAIC) AGING（推进老年医学基础设施和网络发展）倡议，由 R24 拨款资助机制（R24 AG045050）于 2014 年启动，旨在促进 HCSRN 和 OAIC（又名胡椒中心）研究人员以推进跨学科研究议程，重点是推进老年人多种慢性病 (MCC) 的科学研究是一项高效的、来自 18 个 HCSRN 研究中心的科学家参与的跨学科协作努力，嵌入式在医疗保健服务系统内，与以下机构合作，照顾近 200 万名 65 岁及以上的老人来自国家老龄化研究所 (the National Institute on Aging) 建立的 15 个主要大学中心的研究人员根据 R24，与推进 MCC 科学相关的努力集中在：(1) 表征共享独特的数据资源；(2) 支持创新的协作试点项目；(3) 指导新的项目；和早期研究人员；(4) 传播研究方法和研究结果。确定了几个尚未充分研究的、高度优先的研究领域，以及对正式职业的迫切需求为致力于衰老研究病因、预防、和治疗，与 MCC 老年人的护理相关我们扩展的 R33 的总体目标。该计划由 R24 HCSRN-OAICs AGING Initiative 指导委员会及其工作组和外部咨询委员会，旨在详细阐述成功的计划和基础设施 R24，同时将我们的老化计划朝着新的、更雄心勃勃的方向发展，我们将创建新的核心。资源、职业发展机会和资助机会，使患者的利益与这些目标保持一致我们的具体目标是：（1）扩展并进一步开发相关的创新方法。测量和分析、观察研究以及务实的临床试验设计和实施，为改善老年人护理和结果的新型干预措施的开发和测试提供信息与 MCC 合作；(2) 促进新的和早期研究人员的职业发展和成功，包括代表性不足的少数群体，并创建一个全国性的 MCC 学者群体，他们准备建立在职业生涯早期进行富有成效的合作，以促进与以下领域相关的跨学科研究的扩展 MCC 的科学性；(3) 创建新的核心职能，作为促进发展的精心设计的基础设施的一部分以患者为中心的研究，让患者和护理合作伙伴参与研究过程的各个阶段； (4) 资助一系列“P-2-R”（“Pilot-to-R 奖”）拨款，以推进 R33 相关研究优先事项 “P-2-R”赠款将有助于促进 MCC 科学的发展和实施。更大规模、多学科、多地点的研究为继续发展老龄化奠定了基础倡议。