Research Education Component

研究教育部分

• 批准号: 9921711
• 负责人: Jeffrey J Iliff
• 金额: $ 11.26万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9921711
• 关键词: Address; Aging; Alaska Native; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American Indians; Animal Model; Award; Basic Science; Big Data; Bioinformatics; Biological; Brain; Clinic; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communities; Community Developments; Competence; Correlation Studies; Data; Data Set; Dementia; Development; Disease; Ecosystem; Educational Curriculum; Educational workshop; Environment; Etiology; Faculty; Focus Groups; Fostering; Foundations; Funding; Future; Genetic; Goals; Grant; Home environment; Human; Image; Individual; Institutes; Interest Group; Knowledge; Knowledge Portal; Medicine; Memory Loss; Mentors; Mentorship; Minority; Native Americans; Native Hawaiian; Nerve Degeneration; Neurosciences; Pacific Island Americans; Participant; Pathologic; Population; Positioning Attribute; Postdoctoral Fellow; Prevention; Research; Research Personnel; Research Project Grants; Research Support; Resources; Scientist; Series; Structure; Technical Expertise; Time; Training; Translating; Translational Research; Travel; Universities; Washington; base; biological heterogeneity; career; data resource; data sharing; education research; imaging biomarker; improved; innovation; interdisciplinary approach; literacy; meetings; multidisciplinary; neurobehavior; neuropathology; outreach; pre-doctoral; programs; ranpirnase; research and development; tool; transcriptomics; working group

Abstract Research into the causes, presentation, prevention and treatment of Alzheimer's disease and related dementias (ADRD) increasingly demands a team-based multi-disciplinary approach that includes clinicians, clinical and basic science researchers. The goal of the University of Washington Alzheimer's Disease Research Center Research Education Component (UW ADRC REC) is to foster the development of a thriving, innovative and diverse ADRD research community that is able to define the varied biological and mechanistic drivers of ADRD. The UW ADRC REC will first provide a one year broad-based curriculum to REC Trainees, including basic, translational and clinical research trainees, in order to establish a common understanding of the clinical presentation of ADRD as they are ere encountered in the clinic and studied in the lab. Support for the widespread use of teleconferencing at training sessions and UW ADRC meetings will provide access to this dynamic clinical and research environment to ADRD investigators studying aging and ADRD in American Native communities and populations. The UW ADRC REC will second provide support to REC Investigators new to the UW ADRC or entering the ADRD research field for the first time in accessing and interacting with the vast array of expertise, data and resources available within the UW ADRC ecosystem. This support is explicitly targeted to include young investigators whose developing research programs will form the pipeline for research utilizing resources and data generated by the UW ADRC in the future. Last, the UW ADRC REC will seek to fill a critical gap in training and expertise in the use of publicly available ADRD-related `big data' throughout the national ADRD research community. Through its partnership with Seattle-based Sage Bionetworks, it will establish and support an annual two-day ADRD Open Neuroscience Workshop that will help ADRD-focused trainees and investigators develop proficiency with publicly-available datasets, their origins and structures, their user interfaces, and statistical and computational approaches to their use. These workshops will be open to individuals at the UW ADRC and other ADRCs nationally. Through ongoing collaborations Sage Bionetworks, it will further support the seeding and support of mentored Open Neuroscience working groups focused on developing new research projects based on these data. This will include the progressive use of integrated clinical, neuropsychometric, imaging and biomarker, genetic and pathological data generated throughout the UW ADRC in these ADRD Open Neuroscience Workshops.

抽象的 阿尔茨海默病及相关疾病的病因、表现、预防和治疗研究 痴呆症 (ADRD) 越来越需要基于团队的多学科方法，其中包括临床医生、 临床和基础科学研究人员。华盛顿大学阿尔茨海默病的目标 研究中心研究教育部分 (UW ADRC REC) 旨在促进蓬勃发展、 创新且多样化的 ADRD 研究社区，能够定义各种生物学和机制 ADRD 的驱动因素。华盛顿大学 ADRC REC 将首先为 REC 学员提供为期一年的基础广泛的课程， 包括基础、转化和临床研究学员，以建立共识 ADRD 的临床表现，因为它们在诊所遇到并在实验室研究。支持 在培训课程和威斯康星大学 ADRC 会议上广泛使用电话会议将提供 这种动态的临床和研究环境为 ADRD 研究人员提供了在美国研究衰老和 ADRD 的机会 原住民社区和人口。华盛顿大学 ADRC REC 其次将向 REC 调查人员提供支持 刚接触 UW ADRC 或首次进入 ADRD 研究领域并与之互动 华盛顿大学 ADRC 生态系统中提供了大量的专业知识、数据和资源。这个支持是 明确的目标是包括年轻的研究人员，他们正在制定的研究计划将成为 未来利用华盛顿大学 ADRC 生成的资源和数据进行研究。最后，UW ADRC REC 将 寻求填补使用公开的 ADRD 相关“大数据”方面的培训和专业知识方面的关键空白 整个国家 ADRD 研究界。通过与总部位于西雅图的 Sage 合作 Bionetworks，它将建立并支持一年一度的为期两天的 ADRD 开放神经科学研讨会，该研讨会将 帮助以 ADRD 为重点的学员和研究人员提高对公开数据集及其来源的熟练程度 和结构、用户界面以及使用的统计和计算方法。这些 研讨会将向华盛顿大学 ADRC 和全国其他 ADRC 的个人开放。通过持续进行 与 Sage Bionetworks 合作，它将进一步支持受指导的 Open 的种子和支持 神经科学工作组专注于根据这些数据开发新的研究项目。这将 包括逐步使用综合临床、神经心理测量、成像和生物标志物、遗传和 在这些 ADRD 开放神经科学研讨会上，整个 UW ADRC 生成了病理数据。