Shock Center for Aging Research at The Jackson Laborato*

杰克逊实验室休克衰老研究中心*

• 批准号: 7271224
• 负责人: DAVID E HARRISON
• 金额: $ 74.17万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7271224
• 关键词: Shock; Center; Aging; Research; Jackson

DESCRIPTION (provided by applicant): To identify genes and explore molecular pathways that regulate aging and susceptibility to age-related disorders in humans, well-characterized and genetically defined mice offer a choice model system. The Jackson Laboratory has a wealth of inbred and mutant strains of mice, expertise in mouse husbandry, and diversity of expertise in the biology of the mouse as it applies to aging. Establishing a Nathan Shock Center for Excellence in the Biology of Aging at The Jackson Laboratory will support an already significant level of age-related research here and, through a Research Development Core, attract both established investigators and new recruits to explore the relationship of their own research programs with questions pertinent to aging. Moreover, because The Jackson Laboratory is an international resource for information and unique strains of mice, the contribution of a Nathan Shock Center here will be leveraged nationally. Mice from individual Center members' research colonies will be aged in a dispersed Animal Core, that will open an enormous variety of genetic resources relevant to aging to other Center members and external scientists. The Phenome Core will offer an entirely new capability for predictive quantitative trait analysis to accelerate genetic analysis of the biology of aging, by characterizing parameters of aging for a set of commonly used, genetically diverse strains of mice and curating the data with detailed genomic sequence and mapping data in the publicly available Mouse Phenome Database. The Center will also support enhanced capabilities for invivo imaging, physiological measurements, and microscopy to evaluate phenotypes of aging through a Phenotyping Core. The Computing Core will provide support for statistical genetics analysis and workflow management tools. In sum, the Nathan Shock Center at The Jackson Laboratory will lead to enhanced resources for the international community and better understanding of the molecular mechanisms at work in aging and its associated disorders.

描述（由申请人提供）：识别基因并探索分子途径，这些途径调节人类中与年龄相关的疾病的易感性，特征良好且遗传定义的小鼠提供了选择模型系统。杰克逊实验室拥有丰富的近交和突变菌株的小鼠，老鼠饲养方面的专业知识以及适用于衰老的老鼠生物学的专业知识多样性。在杰克逊实验室建立内森型卓越衰老生物学卓越中心将支持本来已经很大的与年龄相关的研究，并通过研究开发核心吸引了既定的研究人员和新的新兵，以探索自己的研究计划与与衰老有关的问题的关系。此外，由于杰克逊实验室是信息和独特的老鼠菌株的国际资源，因此这里的内森冲击中心的贡献将在全国范围内杠杆化。来自各个中心成员研究殖民地的小鼠将以分散的动物核心衰老，该核心将为其他中心成员和外部科学家开放与衰老有关的大量遗传资源。现象核心将通过表征一组常见的小鼠遗传菌株的衰老参数来加速衰老的生物学的遗传分析，从而加速对衰老的生物学的遗传分析，并用详细的基因组序列策划数据的数据，并用详细的基因组序列策划数据，并在公开可用的小鼠现象中映射数据，从而加速了对衰老的生物的遗传分析。该中心还将支持增强的能力，以通过表型核心来评估衰老表型的物质测量和显微镜。计算核心将为统计遗传学分析和工作流管理工具提供支持。总而言之，杰克逊实验室的内森冲击中心将为国际社会提供增强的资源，并更好地了解衰老及其相关疾病的分子机制。