White Matter and Cognition in Parkinson's Disease

帕金森病的白质和认知

• 批准号: 7644852
• 负责人: CATHERINE E PRICE
• 金额: $ 12.26万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7644852
• 关键词: Affect; Age; Appointment; Award; Basal Ganglia; Behavioral; Biochemistry; Biometry; Bradykinesia; Brain; Cell Nucleus; Clinical; Cognition; Cognitive; Cognitive deficits; Control Groups; Corpus striatum structure; Data; Deep Brain Stimulation; Degenerative Disorder; Dementia; Development Plans; Diagnosis; Diagnostic; Diffusion Magnetic Resonance Imaging; Disease; Doctor of Philosophy; Education; Family; Feedback; Fiber; Florida; Funding; Goals; Grant; Health Occupations; Hippocampus (Brain); Impaired cognition; Individual; Intervention; Investigation; Knowledge; Lead; Learning; Magnetic Resonance Imaging; Measurement; Measures; Medical; Medicine; Memory; Memory impairment; Mentorship; Methodology; Methods; Metric; Molecular Biology; Motor; Muscle Rigidity; Neurobehavioral Manifestations; Neurologic; Neurology; Neuropsychology; Neurosciences; Outcome; Parkinson Disease; Participant; Pathology; Patients; Pattern; Play; Predictive Value; Prevalence; Price; Problem Solving; Process; Psyche structure; Public Health; Quality of life; Regression Analysis; Relative (related person); Research; Research Ethics; Research Methodology; Research Personnel; Rest Tremor; Role; Science; Short-Term Memory; Speed; Structure; Symptoms; System; Techniques; Thalamic structure; Training; United States; Universities; Writing; alternative treatment; base; brain behavior; brain volume; career; career development; cognitive change; cognitive function; college; comparison group; flexibility; frontal lobe; gray matter; illness length; imaging modality; improved; interest; medical specialties; memory process; memory retrieval; neuropsychological; novel; processing speed; professor; programs; skills; theories; white matter

DESCRIPTION (provided by applicant): Parkinson's disease (PD) affects more than 1.5 million people in the United States alone; its prevalence increases with age, and the majority of the diagnoses occur over age 60. While PD is primarily associated with motor symptoms such as resting tremor and rigidity, it is also associated with debilitating cognitive symptoms. The uniqueness of this application is the candidate's focus on the role of white matter integrity on cognitive function in PD. Little is known about white matter and cognition in PD despite growing research suggesting pathological changes in the white matter may contribute to the degenerative disease. The career development plan consists of two core training objectives: 1) specialty training on the cognitive-behavioral patterns and theories of PD, 2) focused training on Diffusion Tensor Imaging (DTI) methods. Supplementary training in biostatistics, research ethics and grant writing is included. The candidate's long-term career goals are to apply these skills towards longitudinal investigations examining the predictive value of white versus gray matter on cognitive decline (dementia) in PD and cognitive outcome following PD specific medical interventions (i.e., deep brain stimulation). These research interests are strongly supported by the candidate's primary college, The University of Florida's College of Public Health and Health Professions, as well as the College of Medicine where she has an adjunct appointment. The candidate will carry out her research with the co-mentorship of Professors Dawn Bowers, Ph.D. (Neuropsychology, UF), Thomas Mareci, Ph.D. (Biochemistry and Molecular Biology, UF), Glen Stebbins, Ph.D. (Department of Neurological Sciences, Rush University), and an advisory panel of Professors in the Departments of Neurology, Neuroscience and Biostatistics. The research will determine 1) the contribution of white matter integrity on the processing speed and working memory deficits of idiopathic PD (n=45) relative to that of an age and education matched control group (n=45), and 2) the predictive role of white matter on cognitive change after one year. Methods include a baseline MRI and cognitive assessment with a repeat cognitive assessment in one year. Relevance to Public Health: This project will contribute much needed knowledge about the role of white matter integrity on cognitive function in PD. The information will contribute to our ability to predict cognitive change in PD thereby improving treatment decisions and intervention options for PD.

描述（由申请人提供）：仅在美国，帕金森氏病（PD）就会影响超过150万人；它的患病率随着年龄的增长而增加，大多数诊断发生在60岁以上。虽然PD主要与运动症状（例如静止震颤和僵化）有关，但它也与认知症状衰弱有关。该应用程序的独特性是候选人关注白质完整性对PD认知功能的作用。尽管越来越多的研究表明白质的病理变化可能导致退化性疾病，但对PD中的白质和认知知之甚少。职业发展计划由两个核心培训目标组成：1）关于PD的认知行为模式和理论的专业培训，2）重点培训扩散张量成像（DTI）方法。包括生物统计学，研究伦理和赠款写作的补充培训。候选人的长期职业目标是将这些技能应用于纵向调查，以检查白色与灰质在PD和PD特定医疗干预后PD和认知结果中对灰质的预测价值（即深脑刺激）。这些研究兴趣得到了候选人的小学学院，佛罗里达大学公共卫生与健康专业学院以及她有辅助任命的医学院的强烈支持。候选人将在Dawn Bowers教授博士学位上进行研究。 （神经心理学，UF），Thomas Mareci，博士（生物化学和分子生物学，UF），Glen Stebbins，Ph.D。 （拉什大学神经科学系），以及神经科学，神经科学和生物统计学系教授的咨询小组。该研究将确定1）白质完整性对特发性PD的处理速度和工作记忆缺陷的贡献（n = 45）相对于年龄和教育匹配的对照组（n = 45）和2）一年后，白质在认知变化中的作用。方法包括基线MRI和认知评估，并在一年内重复认知评估。与公共卫生的相关性：该项目将对白质完整性在PD中的认知功能中的作用做出巨大必要的知识。该信息将有助于我们预测PD认知变化的能力，从而改善治疗决策和PD的干预选择。